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Single Umbilical Artery
Roya Sohaey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • 2-vessel cord
              • Absent umbilical artery (UA) 
            • Definitions

              • Single umbilical artery (SUA) cord has 1 umbilical artery (UA) and 1 umbilical vein (UV) instead of 2 UAs and 1 UV
              • Hypoplastic UA (HUA) is variant of SUA
                • HUA is < 1/2 size of normal UA

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Tai C et al: Prevalence of congenital heart disease in an isolated single umbilical artery is low at a tertiary referral center. J Ultrasound Med. ePub, 2020
                                    2. Ismail KI et al: Role of 2-dimensional ultrasound imaging in placental and umbilical cord morphometry: literature and pictorial review. J Ultrasound Med. 38(12):3131-40, 2019
                                    3. Hasegawa J: Ultrasound screening of umbilical cord abnormalities and delivery management. Placenta. 62:66-78, 2018
                                    4. Luo X et al: The risk factors and neonatal outcomes of isolated single umbilical artery in singleton pregnancy: a meta-analysis. Sci Rep. 7(1):7396, 2017
                                    5. Ebrashy A et al: Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach. J Perinat Med. 44(2):131-7, 2016
                                    6. Battarbee AN et al: Association of isolated single umbilical artery with small for gestational age and preterm birth. Obstet Gynecol. 126(4):760-4, 2015
                                    7. Tulek F et al: The effects of isolated single umbilical artery on first and second trimester aneuploidy screening test parameters. J Matern Fetal Neonatal Med. 28(6):690-4, 2015
                                    8. Voskamp BJ et al: Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 42(6):622-8, 2013
                                    9. Hua M et al: Single umbilical artery and its associated findings. Obstet Gynecol. 115(5):930-4, 2010
                                    10. Rembouskos G et al: Single umbilical artery at 11-14 weeks' gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol. 22(6):567-70, 2003
                                    11. Gamzu R et al: Type II single umbilical artery (persistent vitelline artery) in an otherwise normal fetus. Prenat Diagn. 22(11):1040-3, 2002
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • 2-vessel cord
                                                • Absent umbilical artery (UA) 
                                              • Definitions

                                                • Single umbilical artery (SUA) cord has 1 umbilical artery (UA) and 1 umbilical vein (UV) instead of 2 UAs and 1 UV
                                                • Hypoplastic UA (HUA) is variant of SUA
                                                  • HUA is < 1/2 size of normal UA

                                              IMAGING

                                              • General Features

                                                • Ultrasonographic Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          • Gross Pathologic & Surgical Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  DIAGNOSTIC CHECKLIST

                                                                  • Consider

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Tai C et al: Prevalence of congenital heart disease in an isolated single umbilical artery is low at a tertiary referral center. J Ultrasound Med. ePub, 2020
                                                                      2. Ismail KI et al: Role of 2-dimensional ultrasound imaging in placental and umbilical cord morphometry: literature and pictorial review. J Ultrasound Med. 38(12):3131-40, 2019
                                                                      3. Hasegawa J: Ultrasound screening of umbilical cord abnormalities and delivery management. Placenta. 62:66-78, 2018
                                                                      4. Luo X et al: The risk factors and neonatal outcomes of isolated single umbilical artery in singleton pregnancy: a meta-analysis. Sci Rep. 7(1):7396, 2017
                                                                      5. Ebrashy A et al: Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach. J Perinat Med. 44(2):131-7, 2016
                                                                      6. Battarbee AN et al: Association of isolated single umbilical artery with small for gestational age and preterm birth. Obstet Gynecol. 126(4):760-4, 2015
                                                                      7. Tulek F et al: The effects of isolated single umbilical artery on first and second trimester aneuploidy screening test parameters. J Matern Fetal Neonatal Med. 28(6):690-4, 2015
                                                                      8. Voskamp BJ et al: Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 42(6):622-8, 2013
                                                                      9. Hua M et al: Single umbilical artery and its associated findings. Obstet Gynecol. 115(5):930-4, 2010
                                                                      10. Rembouskos G et al: Single umbilical artery at 11-14 weeks' gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol. 22(6):567-70, 2003
                                                                      11. Gamzu R et al: Type II single umbilical artery (persistent vitelline artery) in an otherwise normal fetus. Prenat Diagn. 22(11):1040-3, 2002