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Single Umbilical Artery
Roya Sohaey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Single umbilical artery (SUA)
            • Synonyms

              • 2-vessel cord
              • Absent umbilical artery
            • Definitions

              • Umbilical cord carries only 1 artery and 1 vein
                • Absence of right or left umbilical artery (UA)
                • Normal cord has 2 UA and 1 umbilical vein (UV)
              • Hypoplastic umbilical artery (HUA) is variant of SUA
                • 1 UA is > 50% smaller than other UA

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Battarbee AN et al: Association of isolated single umbilical artery with small for gestational age and preterm birth. Obstet Gynecol. 126(4):760-4, 2015
                                      2. Tulek F et al: The effects of isolated single umbilical artery on first and second trimester aneuploidy screening test parameters. J Matern Fetal Neonatal Med. 28(6):690-4, 2015
                                      3. Voskamp BJ et al: Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 42(6):622-8, 2013
                                      4. Hua M et al: Single umbilical artery and its associated findings. Obstet Gynecol. 115(5):930-4, 2010
                                      5. Sepulveda W et al: Improving sonographic evaluation of the umbilical cord at the second-trimester anatomy scan. J Ultrasound Med. 28(6):831-5, 2009
                                      6. Prucka S et al: Single umbilical artery: what does it mean for the fetus? A case-control analysis of pathologically ascertained cases. Genet Med. 6(1):54-7, 2004
                                      7. Gornall AS et al: Antenatal detection of a single umbilical artery: does it matter? Prenat Diagn. 23(2):117-23, 2003
                                      8. Rembouskos G et al: Single umbilical artery at 11-14 weeks' gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol. 22(6):567-70, 2003
                                      9. Gamzu R et al: Type II single umbilical artery (persistent vitelline artery) in an otherwise normal fetus. Prenat Diagn. 22(11):1040-3, 2002
                                      10. Budorick NE et al: The single umbilical artery in a high-risk patient population: what should be offered? J Ultrasound Med. 20(6):619-27; quiz 628, 2001
                                      11. Degani S et al: Early second-trimester low umbilical coiling index predicts small-for-gestational-age fetuses. J Ultrasound Med. 20(11):1183-8, 2001
                                      12. Chow JS et al: Frequency and nature of structural anomalies in fetuses with single umbilical arteries. J Ultrasound Med. 17(12):765-8, 1998
                                      13. Persutte WH et al: Single umbilical artery: a clinical enigma in modern prenatal diagnosis. Ultrasound Obstet Gynecol. 6(3):216-29, 1995
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Single umbilical artery (SUA)
                                                • Synonyms

                                                  • 2-vessel cord
                                                  • Absent umbilical artery
                                                • Definitions

                                                  • Umbilical cord carries only 1 artery and 1 vein
                                                    • Absence of right or left umbilical artery (UA)
                                                    • Normal cord has 2 UA and 1 umbilical vein (UV)
                                                  • Hypoplastic umbilical artery (HUA) is variant of SUA
                                                    • 1 UA is > 50% smaller than other UA

                                                IMAGING

                                                • General Features

                                                  • Ultrasonographic Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Gross Pathologic & Surgical Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Battarbee AN et al: Association of isolated single umbilical artery with small for gestational age and preterm birth. Obstet Gynecol. 126(4):760-4, 2015
                                                                          2. Tulek F et al: The effects of isolated single umbilical artery on first and second trimester aneuploidy screening test parameters. J Matern Fetal Neonatal Med. 28(6):690-4, 2015
                                                                          3. Voskamp BJ et al: Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 42(6):622-8, 2013
                                                                          4. Hua M et al: Single umbilical artery and its associated findings. Obstet Gynecol. 115(5):930-4, 2010
                                                                          5. Sepulveda W et al: Improving sonographic evaluation of the umbilical cord at the second-trimester anatomy scan. J Ultrasound Med. 28(6):831-5, 2009
                                                                          6. Prucka S et al: Single umbilical artery: what does it mean for the fetus? A case-control analysis of pathologically ascertained cases. Genet Med. 6(1):54-7, 2004
                                                                          7. Gornall AS et al: Antenatal detection of a single umbilical artery: does it matter? Prenat Diagn. 23(2):117-23, 2003
                                                                          8. Rembouskos G et al: Single umbilical artery at 11-14 weeks' gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol. 22(6):567-70, 2003
                                                                          9. Gamzu R et al: Type II single umbilical artery (persistent vitelline artery) in an otherwise normal fetus. Prenat Diagn. 22(11):1040-3, 2002
                                                                          10. Budorick NE et al: The single umbilical artery in a high-risk patient population: what should be offered? J Ultrasound Med. 20(6):619-27; quiz 628, 2001
                                                                          11. Degani S et al: Early second-trimester low umbilical coiling index predicts small-for-gestational-age fetuses. J Ultrasound Med. 20(11):1183-8, 2001
                                                                          12. Chow JS et al: Frequency and nature of structural anomalies in fetuses with single umbilical arteries. J Ultrasound Med. 17(12):765-8, 1998
                                                                          13. Persutte WH et al: Single umbilical artery: a clinical enigma in modern prenatal diagnosis. Ultrasound Obstet Gynecol. 6(3):216-29, 1995