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Sinonasal Adenocarcinoma
Blair A. Winegar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Sinonasal adenocarcinoma (SN AdenoCa)
            • Definitions

              • Malignant neoplasm with glandular differentiation arising from surface epithelium or minor salivary rests

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Bishop JA: Newly Described Tumor Entities in Sinonasal Tract Pathology. Head Neck Pathol. 10(1):23-31, 2016
                                        2. Hoeben A et al: Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment. Head Neck. ePub, 2016
                                        3. Leivo I: Sinonasal adenocarcinoma: update on classification, immunophenotype and molecular features. Head Neck Pathol. 10(1):68-74, 2016
                                        4. Rawal RB et al: Endoscopic resection of sinonasal malignancy: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. ePub, 2016
                                        5. Franchi A et al: Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma. Oral Oncol. 45(9):835-8, 2009
                                        6. Jardeleza C et al: Surgical outcomes of endoscopic management of adenocarcinoma of the sinonasal cavity. Rhinology. 47(4):354-61, 2009
                                        7. Mayr SI et al: Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case-control study. Int Arch Occup Environ Health. Epub ahead of print, 2009
                                        8. Tripodi D et al: Gene expression profiling in sinonasal adenocarcinoma. BMC Med Genomics. 2:65, 2009
                                        9. Holmila R et al: COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. Int J Cancer. 122(9):2154-9, 2008
                                        10. Raghavan P et al: Magnetic resonance imaging of sinonasal malignancies. Top Magn Reson Imaging. 18(4):259-67, 2007
                                        11. Day TA et al: Management of paranasal sinus malignancy. Curr Treat Options Oncol. 6(1):3-18, 2005
                                        12. Korinth D et al: Chromosomal imbalances in wood dust-related adenocarcinomas of the inner nose and their associations with pathological parameters. J Pathol. 207(2):207-15, 2005
                                        13. Orvidas LJ et al: Adenocarcinoma of the nose and paranasal sinuses: a retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients. Head Neck. 27(5):370-5, 2005
                                        14. Suarez C et al: Prognostic factors in sinonasal tumors involving the anterior skull base. Head Neck. 26(2):136-44, 2004
                                        15. Sklar EM et al: Sinonasal intestinal-type adenocarcinoma involvement of the paranasal sinuses. AJNR Am J Neuroradiol. 24(6):1152-5, 2003
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Sinonasal adenocarcinoma (SN AdenoCa)
                                                  • Definitions

                                                    • Malignant neoplasm with glandular differentiation arising from surface epithelium or minor salivary rests

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Bishop JA: Newly Described Tumor Entities in Sinonasal Tract Pathology. Head Neck Pathol. 10(1):23-31, 2016
                                                                              2. Hoeben A et al: Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment. Head Neck. ePub, 2016
                                                                              3. Leivo I: Sinonasal adenocarcinoma: update on classification, immunophenotype and molecular features. Head Neck Pathol. 10(1):68-74, 2016
                                                                              4. Rawal RB et al: Endoscopic resection of sinonasal malignancy: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. ePub, 2016
                                                                              5. Franchi A et al: Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma. Oral Oncol. 45(9):835-8, 2009
                                                                              6. Jardeleza C et al: Surgical outcomes of endoscopic management of adenocarcinoma of the sinonasal cavity. Rhinology. 47(4):354-61, 2009
                                                                              7. Mayr SI et al: Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case-control study. Int Arch Occup Environ Health. Epub ahead of print, 2009
                                                                              8. Tripodi D et al: Gene expression profiling in sinonasal adenocarcinoma. BMC Med Genomics. 2:65, 2009
                                                                              9. Holmila R et al: COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. Int J Cancer. 122(9):2154-9, 2008
                                                                              10. Raghavan P et al: Magnetic resonance imaging of sinonasal malignancies. Top Magn Reson Imaging. 18(4):259-67, 2007
                                                                              11. Day TA et al: Management of paranasal sinus malignancy. Curr Treat Options Oncol. 6(1):3-18, 2005
                                                                              12. Korinth D et al: Chromosomal imbalances in wood dust-related adenocarcinomas of the inner nose and their associations with pathological parameters. J Pathol. 207(2):207-15, 2005
                                                                              13. Orvidas LJ et al: Adenocarcinoma of the nose and paranasal sinuses: a retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients. Head Neck. 27(5):370-5, 2005
                                                                              14. Suarez C et al: Prognostic factors in sinonasal tumors involving the anterior skull base. Head Neck. 26(2):136-44, 2004
                                                                              15. Sklar EM et al: Sinonasal intestinal-type adenocarcinoma involvement of the paranasal sinuses. AJNR Am J Neuroradiol. 24(6):1152-5, 2003