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Sinonasal Fibrous Dysplasia
Yoshimi Anzai, MD, MPH
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Fibrous dysplasia (FD)
              • Synonyms

                • Jaffe-Lichtenstein syndrome: FD with café-au-lait spots
                • Cherubism: Hereditary form, polyostotic, bilateral
                • Leontiasis ossea: Lion-like facial appearance
                • Originally called osteitis fibrosa generalisata
              • Definitions

                • Normal medullary bone replaced by fibroosseous tissue with varying degree of osseous metaplasia

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Kim D et al: Magnetic resonance imaging features of craniofacial fibrous dysplasia. Pol J Radiol. 84:e16-24, 2019
                                              2. Belsuzarri TA et al: McCune-Albright syndrome with craniofacial dysplasia: clinical review and surgical management. Surg Neurol Int. 7(Suppl 6):S165-9, 2016
                                              3. Atalar MH et al: CT and MR imaging in a large series of patients with craniofacial fibrous dysplasia. Pol J Radiol. 80:232-40, 2015
                                              4. De Carlo D et al: Spontaneous involution of diffuse fibrous dysplasia of paranasal sinuses. J Child Neurol. 30(6):767-71, 2015
                                              5. DeKlotz TR et al: Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright Syndrome. Laryngoscope. 123(4):823-8, 2013
                                              6. Schreiber A et al: Fibrous dysplasia of the sinonasal tract and adjacent skull base. Curr Opin Otolaryngol Head Neck Surg. 20(1):45-52, 2012
                                              7. Amit M et al: Surgery versus watchful waiting in patients with craniofacial fibrous dysplasia--a meta-analysis. PLoS One. 6(9):e25179, 2011
                                              8. Ooi EH et al: An alternative management approach to paranasal sinus fibro-osseous lesions. Int Forum Allergy Rhinol. 1(1):55-63, 2011
                                              9. Reis C et al: A rare spontaneous osteosarcoma of the calvarium in a patient with long-standing fibrous dysplasia: CT and MR findings. Br J Radiol. 81(962):e31-4, 2008
                                              10. Hart ES et al: Onset, progression, and plateau of skeletal lesions in fibrous dysplasia and the relationship to functional outcome. J Bone Miner Res. 22(9):1468-74, 2007
                                              11. Shah ZK et al: Magnetic resonance imaging appearances of fibrous dysplasia. Br J Radiol. 78(936):1104-15, 2005
                                              12. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 2004 Jan;59(1):11-25. Review. Erratum in: Clin Radiol. 64(1):107, 2009
                                              13. Cappabianca S et al: Maxillofacial fibrous dysplasia: personal experience with gadoliniumenhanced magnetic resonance imaging. Radiol Med. 113(8):1198-210, 2008
                                              14. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                              15. Eller R et al: Common fibro-osseous lesions of the paranasal sinuses. Otolaryngol Clin North Am. 39(3):585-600, x, 2006
                                              16. Khanna G et al: Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics. 26(1):157-71, 2006
                                              17. Alawi F: Benign fibro-osseous diseases of the maxillofacial bones. A review and differential diagnosis. Am J Clin Pathol. 118 Suppl:S50-70, 2002
                                              18. Tehranzadeh J et al: Computed tomography of Paget disease of the skull versus fibrous dysplasia. Skeletal Radiol. 27:664-72, 1998
                                              19. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                              20. Casselman JW et al: MRI in craniofacial fibrous dysplasia. Neuroradiology. 35(3):234-7, 1993
                                              21. Norris MA et al: Fibrous dysplasia: magnetic resonance imaging appearance at 1.5 tesla. Clin Imaging. 14(3):211-5, 1990
                                              22. Utz JA et al: MR appearance of fibrous dysplasia. J Comput Assist Tomogr. 13(5):845-51, 1989
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Fibrous dysplasia (FD)
                                                          • Synonyms

                                                            • Jaffe-Lichtenstein syndrome: FD with café-au-lait spots
                                                            • Cherubism: Hereditary form, polyostotic, bilateral
                                                            • Leontiasis ossea: Lion-like facial appearance
                                                            • Originally called osteitis fibrosa generalisata
                                                          • Definitions

                                                            • Normal medullary bone replaced by fibroosseous tissue with varying degree of osseous metaplasia

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Kim D et al: Magnetic resonance imaging features of craniofacial fibrous dysplasia. Pol J Radiol. 84:e16-24, 2019
                                                                                          2. Belsuzarri TA et al: McCune-Albright syndrome with craniofacial dysplasia: clinical review and surgical management. Surg Neurol Int. 7(Suppl 6):S165-9, 2016
                                                                                          3. Atalar MH et al: CT and MR imaging in a large series of patients with craniofacial fibrous dysplasia. Pol J Radiol. 80:232-40, 2015
                                                                                          4. De Carlo D et al: Spontaneous involution of diffuse fibrous dysplasia of paranasal sinuses. J Child Neurol. 30(6):767-71, 2015
                                                                                          5. DeKlotz TR et al: Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright Syndrome. Laryngoscope. 123(4):823-8, 2013
                                                                                          6. Schreiber A et al: Fibrous dysplasia of the sinonasal tract and adjacent skull base. Curr Opin Otolaryngol Head Neck Surg. 20(1):45-52, 2012
                                                                                          7. Amit M et al: Surgery versus watchful waiting in patients with craniofacial fibrous dysplasia--a meta-analysis. PLoS One. 6(9):e25179, 2011
                                                                                          8. Ooi EH et al: An alternative management approach to paranasal sinus fibro-osseous lesions. Int Forum Allergy Rhinol. 1(1):55-63, 2011
                                                                                          9. Reis C et al: A rare spontaneous osteosarcoma of the calvarium in a patient with long-standing fibrous dysplasia: CT and MR findings. Br J Radiol. 81(962):e31-4, 2008
                                                                                          10. Hart ES et al: Onset, progression, and plateau of skeletal lesions in fibrous dysplasia and the relationship to functional outcome. J Bone Miner Res. 22(9):1468-74, 2007
                                                                                          11. Shah ZK et al: Magnetic resonance imaging appearances of fibrous dysplasia. Br J Radiol. 78(936):1104-15, 2005
                                                                                          12. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 2004 Jan;59(1):11-25. Review. Erratum in: Clin Radiol. 64(1):107, 2009
                                                                                          13. Cappabianca S et al: Maxillofacial fibrous dysplasia: personal experience with gadoliniumenhanced magnetic resonance imaging. Radiol Med. 113(8):1198-210, 2008
                                                                                          14. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                                                                          15. Eller R et al: Common fibro-osseous lesions of the paranasal sinuses. Otolaryngol Clin North Am. 39(3):585-600, x, 2006
                                                                                          16. Khanna G et al: Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics. 26(1):157-71, 2006
                                                                                          17. Alawi F: Benign fibro-osseous diseases of the maxillofacial bones. A review and differential diagnosis. Am J Clin Pathol. 118 Suppl:S50-70, 2002
                                                                                          18. Tehranzadeh J et al: Computed tomography of Paget disease of the skull versus fibrous dysplasia. Skeletal Radiol. 27:664-72, 1998
                                                                                          19. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                                                                          20. Casselman JW et al: MRI in craniofacial fibrous dysplasia. Neuroradiology. 35(3):234-7, 1993
                                                                                          21. Norris MA et al: Fibrous dysplasia: magnetic resonance imaging appearance at 1.5 tesla. Clin Imaging. 14(3):211-5, 1990
                                                                                          22. Utz JA et al: MR appearance of fibrous dysplasia. J Comput Assist Tomogr. 13(5):845-51, 1989