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Sinonasal Melanoma
Yoshimi Anzai, MD, MPH
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Sinonasal melanoma (SNM)
            • Definitions

              • Malignant transformation of melanocytes migrating from neural crest in sinonasal cavity

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Gras-Cabrerizo JR et al: Management of sinonasal mucosal melanomas and comparison of classification staging systems. Am J Rhinol Allergy. 29(1):e37-40, 2015
                                          2. Jangard M et al: TERT promoter mutations in sinonasal malignant melanoma: a study of 49 cases. Melanoma Res. 25(3):185-8, 2015
                                          3. Gilain L et al: Mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis. 131(6):365-9, 2014
                                          4. Michel J et al: Sinonasal mucosal melanomas: the prognostic value of tumor classifications. Head Neck. 36(3):311-6, 2014
                                          5. Moreno MA et al: Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer. 116(9):2215-23, 2010
                                          6. Wu AJ et al: Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol. 33(3):281-5, 2010
                                          7. Dauer EH et al: Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg. 138(3):347-52, 2008
                                          8. Kim DK et al: Ki67 antigen as a predictive factor for prognosis of sinonasal mucosal melanoma. Clin Exp Otorhinolaryngol. 1(4):206-10, 2008
                                          9. McLean N et al: Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma. Oral Oncol. 44(11):1039-46, 2008
                                          10. Raghavan P et al: Magnetic resonance imaging of sinonasal malignancies. Top Magn Reson Imaging. 18(4):259-67, 2007
                                          11. Day TA et al: Management of paranasal sinus malignancy. Curr Treat Options Oncol. 6(1):3-18, 2005
                                          12. Chang PC et al: Perineural spread of malignant melanoma of the head and neck: clinical and imaging features. AJNR Am J Neuroradiol. 25(1):5-11, 2004
                                          13. Loevner LA et al: Imaging of neoplasms of the paranasal sinuses. Magn Reson Imaging Clin N Am. 10(3):467-93, 2002
                                          14. Kim SS et al: Malignant melanoma of the sinonasal cavity: explanation of magnetic resonance signal intensities with histopathologic characteristics. Am J Otolaryngol. 21(6):366-78, 2000
                                          15. Yousem DM et al: Primary malignant melanoma of the sinonasal cavity: MR imaging evaluation. Radiographics. 16(5):1101-10, 1996
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Sinonasal melanoma (SNM)
                                                    • Definitions

                                                      • Malignant transformation of melanocytes migrating from neural crest in sinonasal cavity

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Gras-Cabrerizo JR et al: Management of sinonasal mucosal melanomas and comparison of classification staging systems. Am J Rhinol Allergy. 29(1):e37-40, 2015
                                                                                  2. Jangard M et al: TERT promoter mutations in sinonasal malignant melanoma: a study of 49 cases. Melanoma Res. 25(3):185-8, 2015
                                                                                  3. Gilain L et al: Mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis. 131(6):365-9, 2014
                                                                                  4. Michel J et al: Sinonasal mucosal melanomas: the prognostic value of tumor classifications. Head Neck. 36(3):311-6, 2014
                                                                                  5. Moreno MA et al: Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer. 116(9):2215-23, 2010
                                                                                  6. Wu AJ et al: Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol. 33(3):281-5, 2010
                                                                                  7. Dauer EH et al: Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg. 138(3):347-52, 2008
                                                                                  8. Kim DK et al: Ki67 antigen as a predictive factor for prognosis of sinonasal mucosal melanoma. Clin Exp Otorhinolaryngol. 1(4):206-10, 2008
                                                                                  9. McLean N et al: Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma. Oral Oncol. 44(11):1039-46, 2008
                                                                                  10. Raghavan P et al: Magnetic resonance imaging of sinonasal malignancies. Top Magn Reson Imaging. 18(4):259-67, 2007
                                                                                  11. Day TA et al: Management of paranasal sinus malignancy. Curr Treat Options Oncol. 6(1):3-18, 2005
                                                                                  12. Chang PC et al: Perineural spread of malignant melanoma of the head and neck: clinical and imaging features. AJNR Am J Neuroradiol. 25(1):5-11, 2004
                                                                                  13. Loevner LA et al: Imaging of neoplasms of the paranasal sinuses. Magn Reson Imaging Clin N Am. 10(3):467-93, 2002
                                                                                  14. Kim SS et al: Malignant melanoma of the sinonasal cavity: explanation of magnetic resonance signal intensities with histopathologic characteristics. Am J Otolaryngol. 21(6):366-78, 2000
                                                                                  15. Yousem DM et al: Primary malignant melanoma of the sinonasal cavity: MR imaging evaluation. Radiographics. 16(5):1101-10, 1996