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Sinonasal Nerve Sheath Tumor
Yoshimi Anzai, MD, MPH
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Peripheral nerve sheath tumor (PNST)
                  • Schwannoma = neurilemoma
              • Definitions

                • Slow-growing, benign tumors of nerve sheath (schwannoma) or peripheral nerve tissue (neurofibroma)

              IMAGING

              • General Features

                • Imaging Recommendations

                  • CT Findings

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Abdel Razek AAK et al: Peripheral nerve sheath tumors of head and neck: imaging-based review of World Health Organization Classification. J Comput Assist Tomogr. 44(6):928-40, 2020
                                        2. Alrasheed W et al: A rare case of nasal septal schwannoma: case report and literature review. Int J Surg Case Rep. 55:149-51, 2019
                                        3. Forer B et al: Endoscopic resection of sinonasal tract schwannoma: presentation, treatment, and outcome in 10 cases. Ann Otol Rhinol Laryngol. 124(8):603-8, 2015
                                        4. Yang B et al: Magnetic resonance imaging features of schwannoma of the sinonasal tract. J Comput Assist Tomogr. 39(6):860-5, 2015
                                        5. Eggesbø HB: Imaging of sinonasal tumours. Cancer Imaging. 12:136-52, 2012
                                        6. Ulu EM et al: Sinonasal schwannoma of the middle turbinate. Diagn Interv Radiol. 16(2):129-31, 2010
                                        7. Fang WS et al: An unusual sinonasal tumor: soft tissue perineurioma. AJNR Am J Neuroradiol. 30(2):437-9, 2009
                                        8. George KJ et al: Nasoethmoid schwannoma with intracranial extension. Case report and review of literature. Br J Neurosurg. 23(1):83-5, 2009
                                        9. Jacopo G et al: Atypical sinonasal Schwannomas: a difficult diagnostic challenge. Auris Nasus Larynx. 36(4):482-6, 2009
                                        10. Tidmore T et al: Columellar schwannoma. Ear Nose Throat J. 88(10):E38-40, 2009
                                        11. Sheikh HY et al: Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. J Laryngol Otol. 122(6):598-602, 2008
                                        12. Valencia MP et al: Congenital and acquired lesions of the nasal septum: a practical guide for differential diagnosis. Radiographics. 28(1):205-24; quiz 326, 2008
                                        13. Fujiyoshi F et al: CT and MR imaging of nasoethmoid schwannoma with intracranial extension. AJR Am J Roentgenol. 1997 Dec;169(6):1754-5.
                                        14. Mey KH et al: Sinonasal schwannoma--a clinicopathological analysis of five rare cases. Rhinology. 44(1):46-52, 2006
                                        15. Yu E et al: CT and MR imaging findings in sinonasal schwannoma. AJNR Am J Neuroradiol. 27(4):929-30, 2006
                                        16. Buob D et al: Schwannoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of 5 cases. Arch Pathol Lab Med. 127(9):1196-9, 2003
                                        17. Cakmak O et al: Nasal and paranasal sinus schwannomas. Eur Arch Otorhinolaryngol. 260(4):195-7, 2003
                                        18. Hasegawa SL et al: Schwannomas of the sinonasal tract and nasopharynx. Mod Pathol. 10(8):777-84, 1997
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Peripheral nerve sheath tumor (PNST)
                                                        • Schwannoma = neurilemoma
                                                    • Definitions

                                                      • Slow-growing, benign tumors of nerve sheath (schwannoma) or peripheral nerve tissue (neurofibroma)

                                                    IMAGING

                                                    • General Features

                                                      • Imaging Recommendations

                                                        • CT Findings

                                                          • MR Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Abdel Razek AAK et al: Peripheral nerve sheath tumors of head and neck: imaging-based review of World Health Organization Classification. J Comput Assist Tomogr. 44(6):928-40, 2020
                                                                              2. Alrasheed W et al: A rare case of nasal septal schwannoma: case report and literature review. Int J Surg Case Rep. 55:149-51, 2019
                                                                              3. Forer B et al: Endoscopic resection of sinonasal tract schwannoma: presentation, treatment, and outcome in 10 cases. Ann Otol Rhinol Laryngol. 124(8):603-8, 2015
                                                                              4. Yang B et al: Magnetic resonance imaging features of schwannoma of the sinonasal tract. J Comput Assist Tomogr. 39(6):860-5, 2015
                                                                              5. Eggesbø HB: Imaging of sinonasal tumours. Cancer Imaging. 12:136-52, 2012
                                                                              6. Ulu EM et al: Sinonasal schwannoma of the middle turbinate. Diagn Interv Radiol. 16(2):129-31, 2010
                                                                              7. Fang WS et al: An unusual sinonasal tumor: soft tissue perineurioma. AJNR Am J Neuroradiol. 30(2):437-9, 2009
                                                                              8. George KJ et al: Nasoethmoid schwannoma with intracranial extension. Case report and review of literature. Br J Neurosurg. 23(1):83-5, 2009
                                                                              9. Jacopo G et al: Atypical sinonasal Schwannomas: a difficult diagnostic challenge. Auris Nasus Larynx. 36(4):482-6, 2009
                                                                              10. Tidmore T et al: Columellar schwannoma. Ear Nose Throat J. 88(10):E38-40, 2009
                                                                              11. Sheikh HY et al: Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. J Laryngol Otol. 122(6):598-602, 2008
                                                                              12. Valencia MP et al: Congenital and acquired lesions of the nasal septum: a practical guide for differential diagnosis. Radiographics. 28(1):205-24; quiz 326, 2008
                                                                              13. Fujiyoshi F et al: CT and MR imaging of nasoethmoid schwannoma with intracranial extension. AJR Am J Roentgenol. 1997 Dec;169(6):1754-5.
                                                                              14. Mey KH et al: Sinonasal schwannoma--a clinicopathological analysis of five rare cases. Rhinology. 44(1):46-52, 2006
                                                                              15. Yu E et al: CT and MR imaging findings in sinonasal schwannoma. AJNR Am J Neuroradiol. 27(4):929-30, 2006
                                                                              16. Buob D et al: Schwannoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of 5 cases. Arch Pathol Lab Med. 127(9):1196-9, 2003
                                                                              17. Cakmak O et al: Nasal and paranasal sinus schwannomas. Eur Arch Otorhinolaryngol. 260(4):195-7, 2003
                                                                              18. Hasegawa SL et al: Schwannomas of the sinonasal tract and nasopharynx. Mod Pathol. 10(8):777-84, 1997