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Sinonasal Neuroendocrine Carcinoma
Blair A. Winegar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Sinonasal neuroendocrine carcinoma (SNEC)
              • Esthesioneuroblastoma (ENB)
              • Sinonasal undifferentiated carcinoma (SNUC)
              • Small cell undifferentiated neuroendocrine carcinoma (SCUNC)
              • Neuroendocrine carcinoma (NEC)
            • Definitions

              • Rare malignancy of epithelial origin expressing neuroendocrine markers
                • Pathologically distinguishable from other sinonasal neuroectodermal tumors: ENB, SNUC, SCUNC
                • Considered version of ENB with more epithelial carcinomatous features

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Subedi N et al: Neuroendocrine tumours of the head and neck: anatomical, functional and molecular imaging and contemporary management. Cancer Imaging. 13(3):407-22, 2013
                                          2. Mitchell EH et al: Multimodality treatment for sinonasal neuroendocrine carcinoma. Head Neck. Nov 2. 34(10):1372-6, 2011
                                          3. Likhacheva A et al: Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome. Head Neck Oncol. 3:32, 2011
                                          4. Rischin D et al: Sinonasal malignancies of neuroendocrine origin. Hematol Oncol Clin North Am. 22(6):1297-316, xi, 2008
                                          5. Rosenthal DI et al: Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer. 101(11):2567-73, 2004
                                          6. Fitzek MM et al: Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer. 94(10):2623-34, 2002
                                          7. Mills SE: Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol. 15(3):264-78, 2002
                                          8. Smith SR et al: A clinicopathological study of sinonasal neuroendocrine carcinoma and sinonasal undifferentiated carcinoma. Laryngoscope. 110(10 Pt 1):1617-22, 2000
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Sinonasal neuroendocrine carcinoma (SNEC)
                                                      • Esthesioneuroblastoma (ENB)
                                                      • Sinonasal undifferentiated carcinoma (SNUC)
                                                      • Small cell undifferentiated neuroendocrine carcinoma (SCUNC)
                                                      • Neuroendocrine carcinoma (NEC)
                                                    • Definitions

                                                      • Rare malignancy of epithelial origin expressing neuroendocrine markers
                                                        • Pathologically distinguishable from other sinonasal neuroectodermal tumors: ENB, SNUC, SCUNC
                                                        • Considered version of ENB with more epithelial carcinomatous features

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Subedi N et al: Neuroendocrine tumours of the head and neck: anatomical, functional and molecular imaging and contemporary management. Cancer Imaging. 13(3):407-22, 2013
                                                                                  2. Mitchell EH et al: Multimodality treatment for sinonasal neuroendocrine carcinoma. Head Neck. Nov 2. 34(10):1372-6, 2011
                                                                                  3. Likhacheva A et al: Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome. Head Neck Oncol. 3:32, 2011
                                                                                  4. Rischin D et al: Sinonasal malignancies of neuroendocrine origin. Hematol Oncol Clin North Am. 22(6):1297-316, xi, 2008
                                                                                  5. Rosenthal DI et al: Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer. 101(11):2567-73, 2004
                                                                                  6. Fitzek MM et al: Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer. 94(10):2623-34, 2002
                                                                                  7. Mills SE: Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol. 15(3):264-78, 2002
                                                                                  8. Smith SR et al: A clinicopathological study of sinonasal neuroendocrine carcinoma and sinonasal undifferentiated carcinoma. Laryngoscope. 110(10 Pt 1):1617-22, 2000