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Sinonasal Osteosarcoma
Blair A. Winegar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Sinonasal osteosarcoma (OSa)
            • Definitions

              • Rare, malignant bone tumor arising from primitive bone-forming mesenchyma

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Coca-Pelaz A et al: Radiation-induced sarcomas of the head and neck: a systematic review. Adv Ther. 38(1):90-108, 2020
                                            2. Luo Z et al: Head and neck osteosarcoma: CT and MR imaging features. Dentomaxillofac Radiol. 49(2):20190202, 2020
                                            3. Erdur ZB et al: Osteosarcoma of the ethmoid sinus. J Craniofac Surg. 29(5):e487-88, 2018
                                            4. Fujiwara T et al: Second primary osteosarcomas in patients with retinoblastoma. Jpn J Clin Oncol. 45(12):1139-45, 2015
                                            5. Lee RJ et al: Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study. JAMA Otolaryngol Head Neck Surg. 141(5):470-7, 2015
                                            6. Wang S et al: Osteosarcoma of the jaws: demographic and CT imaging features. Dentomaxillofac Radiol. 41(1):37-42, 2012
                                            7. Amaral MB et al: Advanced osteosarcoma of the maxilla: a case report. Med Oral Patol Oral Cir Bucal. 13(8):E492-5, 2008
                                            8. Franco GutiƩrrez V et al: Radiation-induced sarcomas of the head and neck. J Craniofac Surg. 19(5):1287-91, 2008
                                            9. Jasnau S et al: Craniofacial osteosarcoma experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol. 44(3):286-94, 2008
                                            10. Sargi Z et al: Pathology quiz case. Sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg. 134(12):1343, 1344, 2008
                                            11. McHugh JB et al: Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons. Cancer. 107(3):554-62, 2006
                                            12. Tseng CC et al: Pathology quiz case 2. Postirradiation sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg. 131(2):173, 175-6, 2005
                                            13. Nakamura T et al: Osteosarcoma metastatic to the mandible: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 91(4):452-4, 2001
                                            14. Maes P et al: Primary and secondary osteosarcoma of the face: a rare childhood malignancy. Med Pediatr Oncol. 30(3):170-4, 1998
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Sinonasal osteosarcoma (OSa)
                                                      • Definitions

                                                        • Rare, malignant bone tumor arising from primitive bone-forming mesenchyma

                                                      IMAGING

                                                      • General Features

                                                        • Imaging Recommendations

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Coca-Pelaz A et al: Radiation-induced sarcomas of the head and neck: a systematic review. Adv Ther. 38(1):90-108, 2020
                                                                                      2. Luo Z et al: Head and neck osteosarcoma: CT and MR imaging features. Dentomaxillofac Radiol. 49(2):20190202, 2020
                                                                                      3. Erdur ZB et al: Osteosarcoma of the ethmoid sinus. J Craniofac Surg. 29(5):e487-88, 2018
                                                                                      4. Fujiwara T et al: Second primary osteosarcomas in patients with retinoblastoma. Jpn J Clin Oncol. 45(12):1139-45, 2015
                                                                                      5. Lee RJ et al: Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study. JAMA Otolaryngol Head Neck Surg. 141(5):470-7, 2015
                                                                                      6. Wang S et al: Osteosarcoma of the jaws: demographic and CT imaging features. Dentomaxillofac Radiol. 41(1):37-42, 2012
                                                                                      7. Amaral MB et al: Advanced osteosarcoma of the maxilla: a case report. Med Oral Patol Oral Cir Bucal. 13(8):E492-5, 2008
                                                                                      8. Franco GutiƩrrez V et al: Radiation-induced sarcomas of the head and neck. J Craniofac Surg. 19(5):1287-91, 2008
                                                                                      9. Jasnau S et al: Craniofacial osteosarcoma experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol. 44(3):286-94, 2008
                                                                                      10. Sargi Z et al: Pathology quiz case. Sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg. 134(12):1343, 1344, 2008
                                                                                      11. McHugh JB et al: Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons. Cancer. 107(3):554-62, 2006
                                                                                      12. Tseng CC et al: Pathology quiz case 2. Postirradiation sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg. 131(2):173, 175-6, 2005
                                                                                      13. Nakamura T et al: Osteosarcoma metastatic to the mandible: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 91(4):452-4, 2001
                                                                                      14. Maes P et al: Primary and secondary osteosarcoma of the face: a rare childhood malignancy. Med Pediatr Oncol. 30(3):170-4, 1998