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Sinonasal Undifferentiated Carcinoma
Blair A. Winegar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Sinonasal undifferentiated carcinoma (´╗┐SNUC)
            • Synonyms

              • Undifferentiated sinonasal malignant neoplasm
            • Definitions

              • Rare, aggressive, sinonasal nonsquamous cell epithelial or nonepithelial malignant neoplasm of varying histogenesis

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Chitguppi C et al: Loss of SMARCB1 expression confers poor prognosis to sinonasal undifferentiated carcinoma. J Neurol Surg B Skull Base. 81(6):610-9, 2020
                                              2. Choi KY et al: Clinical implication of diagnostic and histopathologic discrepancies in sinonasal malignancies. Laryngoscope. 131(5):E1468-75, 2020
                                              3. Amit M et al: Induction chemotherapy response as a guide for treatment optimization in sinonasal undifferentiated carcinoma. J Clin Oncol. 37(6):504-12, 2019
                                              4. Elkhatib AH et al: Role of 18 F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. Laryngoscope. 127(2):321-4, 2017
                                              5. Shatzkes DR et al: Imaging appearance of SMARCB1 (INI1)-deficient sinonasal carcinoma: a newly described sinonasal malignancy. AJNR Am J Neuroradiol. 37(10):1925-9, 2016
                                              6. Xu CC et al: Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. J Otolaryngol Head Neck Surg. 42:2, 2013
                                              7. Tanzler ED et al: Management of sinonasal undifferentiated carcinoma. Head Neck. 30(5):595-9, 2008
                                              8. Ejaz A et al: Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol. 12(3):134-43, 2005
                                              9. Kim BS et al: Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol. 25(3):162-6, 2004
                                              10. Phillips CD et al: Sinonasal undifferentiated carcinoma: CT and MR imaging of an uncommon neoplasm of the nasal cavity. Radiology. 202(2):477-80, 1997
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Sinonasal undifferentiated carcinoma (´╗┐SNUC)
                                                        • Synonyms

                                                          • Undifferentiated sinonasal malignant neoplasm
                                                        • Definitions

                                                          • Rare, aggressive, sinonasal nonsquamous cell epithelial or nonepithelial malignant neoplasm of varying histogenesis

                                                        IMAGING

                                                        • General Features

                                                          • Imaging Recommendations

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Chitguppi C et al: Loss of SMARCB1 expression confers poor prognosis to sinonasal undifferentiated carcinoma. J Neurol Surg B Skull Base. 81(6):610-9, 2020
                                                                                          2. Choi KY et al: Clinical implication of diagnostic and histopathologic discrepancies in sinonasal malignancies. Laryngoscope. 131(5):E1468-75, 2020
                                                                                          3. Amit M et al: Induction chemotherapy response as a guide for treatment optimization in sinonasal undifferentiated carcinoma. J Clin Oncol. 37(6):504-12, 2019
                                                                                          4. Elkhatib AH et al: Role of 18 F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. Laryngoscope. 127(2):321-4, 2017
                                                                                          5. Shatzkes DR et al: Imaging appearance of SMARCB1 (INI1)-deficient sinonasal carcinoma: a newly described sinonasal malignancy. AJNR Am J Neuroradiol. 37(10):1925-9, 2016
                                                                                          6. Xu CC et al: Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. J Otolaryngol Head Neck Surg. 42:2, 2013
                                                                                          7. Tanzler ED et al: Management of sinonasal undifferentiated carcinoma. Head Neck. 30(5):595-9, 2008
                                                                                          8. Ejaz A et al: Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol. 12(3):134-43, 2005
                                                                                          9. Kim BS et al: Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol. 25(3):162-6, 2004
                                                                                          10. Phillips CD et al: Sinonasal undifferentiated carcinoma: CT and MR imaging of an uncommon neoplasm of the nasal cavity. Radiology. 202(2):477-80, 1997