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Sinus Histiocytosis (Rosai-Dorfman) of Head and Neck
H. Ric Harnsberger, MD; Kathryn E. Dean, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Sinus histiocytosis (SH)
            • Synonyms

              • SH with massive lymphadenopathy, Rosai-Dorfman disease
            • Definitions

              • Benign, pseudolymphomatous, clinicopathologic entity of unknown etiology

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Alwani MM et al: Manifestations of pediatric extranodal Rosai Dorfman disease in the head and neck. Int J Pediatr Otorhinolaryngol. 131:109851, 2020
                                        2. Wang C et al: Intracranial Rosai-Dorfman disease with the petroclival and parasellar involvement mimicking multiple meningiomas: a case report and review of literature. Medicine (Baltimore). 98(18):e15548, 2019
                                        3. Wang Y et al: Neuroimaging features of CNS histiocytosis syndromes. Clin Imaging. 60(1):131-40, 2019
                                        4. Cracolici V et al: Head and neck sinus histiocytosis with massive lymphadenopathy radiology-pathology correlation. Head Neck Pathol. 13(4):656-60, 2018
                                        5. Mar WA et al: Rosai-Dorfman disease: manifestations outside of the head and neck. AJR Am J Roentgenol. 208(4):721-32, 2017
                                        6. Hong CS et al: Redefining the Prevalence of dural involvement in Rosai-Dorfman disease of the central nervous system. World Neurosurg. 90:702.e13-702.e20, 2016
                                        7. Dalia S et al: Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 21(4):322-7, 2014
                                        8. Liu L et al: Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases. Am J Clin Pathol. 140(3):395-402, 2013
                                        9. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                        10. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006
                                        11. Konishi E et al: Isolated intracranial Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy). AJNR Am J Neuroradiol. 24(3):515-8, 2003
                                        12. Wang E et al: Rosai-Dorfman disease presenting with isolated bilateral orbital masses: report of two cases. AJNR Am J Neuroradiol. 22(7):1386-8, 2001
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Sinus histiocytosis (SH)
                                                  • Synonyms

                                                    • SH with massive lymphadenopathy, Rosai-Dorfman disease
                                                  • Definitions

                                                    • Benign, pseudolymphomatous, clinicopathologic entity of unknown etiology

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Alwani MM et al: Manifestations of pediatric extranodal Rosai Dorfman disease in the head and neck. Int J Pediatr Otorhinolaryngol. 131:109851, 2020
                                                                              2. Wang C et al: Intracranial Rosai-Dorfman disease with the petroclival and parasellar involvement mimicking multiple meningiomas: a case report and review of literature. Medicine (Baltimore). 98(18):e15548, 2019
                                                                              3. Wang Y et al: Neuroimaging features of CNS histiocytosis syndromes. Clin Imaging. 60(1):131-40, 2019
                                                                              4. Cracolici V et al: Head and neck sinus histiocytosis with massive lymphadenopathy radiology-pathology correlation. Head Neck Pathol. 13(4):656-60, 2018
                                                                              5. Mar WA et al: Rosai-Dorfman disease: manifestations outside of the head and neck. AJR Am J Roentgenol. 208(4):721-32, 2017
                                                                              6. Hong CS et al: Redefining the Prevalence of dural involvement in Rosai-Dorfman disease of the central nervous system. World Neurosurg. 90:702.e13-702.e20, 2016
                                                                              7. Dalia S et al: Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 21(4):322-7, 2014
                                                                              8. Liu L et al: Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases. Am J Clin Pathol. 140(3):395-402, 2013
                                                                              9. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                                                              10. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006
                                                                              11. Konishi E et al: Isolated intracranial Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy). AJNR Am J Neuroradiol. 24(3):515-8, 2003
                                                                              12. Wang E et al: Rosai-Dorfman disease presenting with isolated bilateral orbital masses: report of two cases. AJNR Am J Neuroradiol. 22(7):1386-8, 2001