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Sinus Histiocytosis (Rosai-Dorfman)
Evelyn W. K. Tang, MBBS, FRCR; Yolanda Y. P. Lee, MBChB, FRCR; Simon S. M. Wong, MBBS, FRCR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Rosai-Dorfman disease (RD)
          • Synonyms

            • Sinus histiocytosis with massive lymphadenopathy
          • Definitions

            • Rare, benign disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation

          IMAGING

          • General Features

            • Imaging Recommendations

              • Ultrasonographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            • Immunohistochemical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Mar WA et al: Rosai-Dorfman disease: manifestations outside of the head and neck. AJR Am J Roentgenol. 208(4):721-732, 2017
                                        2. Louis DN et al: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 131(6):803-20, 2016
                                        3. McClellan SF et al: Orbital Rosai-Dorfman disease: a literature review. Orbit. 32(5):341-6, 2013
                                        4. Wimmer DB et al: Extranodal rosai-dorfman disease associated with increased numbers of immunoglobulin g4 plasma cells involving the colon: case report with literature review. Arch Pathol Lab Med. 137(7):999-1004, 2013
                                        5. Raslan OA et al: Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol. 196(2):W187-93, 2011
                                        6. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                        7. Guven G et al: Rosai Dorfman disease of the parotid and submandibular glands: salivary gland scintigraphy and oral findings in two siblings. Dentomaxillofac Radiol. 36(7):428-33, 2007
                                        8. Louis DN et al: WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon: IARC Press, 2007
                                        9. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006
                                        10. Lim R et al: FDG PET of Rosai-Dorfman disease of the thymus. AJR Am J Roentgenol. 182(2):514, 2004
                                        11. Yu JQ et al: Demonstration of increased FDG activity in Rosai-Dorfman disease on positron emission tomography. Clin Nucl Med. 29(3):209-10, 2004
                                        12. Wang E et al: Rosai-Dorfman disease presenting with isolated bilateral orbital masses: report of two cases. AJNR Am J Neuroradiol. 22(7):1386-8, 2001
                                        13. Carbone A et al: Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck. Ann Otol Rhinol Laryngol. 108(11 Pt 1):1095-104, 1999
                                        14. McAlister WH et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol. 20(6):425-32, 1990
                                        15. Rosai J et al: Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 87(1):63-70, 1969
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Rosai-Dorfman disease (RD)
                                                • Synonyms

                                                  • Sinus histiocytosis with massive lymphadenopathy
                                                • Definitions

                                                  • Rare, benign disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Ultrasonographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Microscopic Features

                                                                  • Immunohistochemical Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Mar WA et al: Rosai-Dorfman disease: manifestations outside of the head and neck. AJR Am J Roentgenol. 208(4):721-732, 2017
                                                                              2. Louis DN et al: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 131(6):803-20, 2016
                                                                              3. McClellan SF et al: Orbital Rosai-Dorfman disease: a literature review. Orbit. 32(5):341-6, 2013
                                                                              4. Wimmer DB et al: Extranodal rosai-dorfman disease associated with increased numbers of immunoglobulin g4 plasma cells involving the colon: case report with literature review. Arch Pathol Lab Med. 137(7):999-1004, 2013
                                                                              5. Raslan OA et al: Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol. 196(2):W187-93, 2011
                                                                              6. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                                                              7. Guven G et al: Rosai Dorfman disease of the parotid and submandibular glands: salivary gland scintigraphy and oral findings in two siblings. Dentomaxillofac Radiol. 36(7):428-33, 2007
                                                                              8. Louis DN et al: WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon: IARC Press, 2007
                                                                              9. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006
                                                                              10. Lim R et al: FDG PET of Rosai-Dorfman disease of the thymus. AJR Am J Roentgenol. 182(2):514, 2004
                                                                              11. Yu JQ et al: Demonstration of increased FDG activity in Rosai-Dorfman disease on positron emission tomography. Clin Nucl Med. 29(3):209-10, 2004
                                                                              12. Wang E et al: Rosai-Dorfman disease presenting with isolated bilateral orbital masses: report of two cases. AJNR Am J Neuroradiol. 22(7):1386-8, 2001
                                                                              13. Carbone A et al: Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck. Ann Otol Rhinol Laryngol. 108(11 Pt 1):1095-104, 1999
                                                                              14. McAlister WH et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol. 20(6):425-32, 1990
                                                                              15. Rosai J et al: Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 87(1):63-70, 1969