Injury of sinusoidal endothelial cells leading to sinusoidal obstruction and postsinusoidal portal hypertension
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bonifazi F et al: Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation. Front Immunol. 11:489, 2020
de Lédinghen V et al: Sinusoidal obstruction syndrome. Clin Res Hepatol Gastroenterol. 44(4):480-5, 2020
Mahadeo KM et al: Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol. 7(1):e61-72, 2020
Thumar VD et al: Spectral Doppler ultrasound can help diagnose children with hepatic sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. Ultrasound Q. 36(1):6-14, 2020
Matsukuma KE et al: Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 7(Suppl 1):S21-31, 2016
Kambham N et al: Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol. 21(5):301-20, 2014
Zhou H et al: Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features. Korean J Radiol. 15(2):218-25, 2014
Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
Coppell JA et al: Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 16(2):157-68, 2010
Chung YE et al: Electronic clinical challenges and images in GI. Hepatic venoocclusive disease. Gastroenterology. 135(1):e3-4, 2008
Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
van den Bosch MA et al: MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation. Eur Radiol. 10(8):1290-3, 2000
Lassau N et al: Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients. Radiology. 204(2):545-52, 1997
McDonald GB et al: Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 118(4):255-67, 1993
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Hepatic sinusoidal obstruction syndrome (SOS)
Synonyms
Venoocclusive disease (VOD)
Definitions
Injury of sinusoidal endothelial cells leading to sinusoidal obstruction and postsinusoidal portal hypertension
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bonifazi F et al: Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation. Front Immunol. 11:489, 2020
de Lédinghen V et al: Sinusoidal obstruction syndrome. Clin Res Hepatol Gastroenterol. 44(4):480-5, 2020
Mahadeo KM et al: Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol. 7(1):e61-72, 2020
Thumar VD et al: Spectral Doppler ultrasound can help diagnose children with hepatic sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. Ultrasound Q. 36(1):6-14, 2020
Matsukuma KE et al: Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 7(Suppl 1):S21-31, 2016
Kambham N et al: Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol. 21(5):301-20, 2014
Zhou H et al: Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features. Korean J Radiol. 15(2):218-25, 2014
Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
Coppell JA et al: Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 16(2):157-68, 2010
Chung YE et al: Electronic clinical challenges and images in GI. Hepatic venoocclusive disease. Gastroenterology. 135(1):e3-4, 2008
Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
van den Bosch MA et al: MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation. Eur Radiol. 10(8):1290-3, 2000
Lassau N et al: Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients. Radiology. 204(2):545-52, 1997
McDonald GB et al: Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 118(4):255-67, 1993
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