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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Hepatic sinusoidal obstruction syndrome (SOS)
Synonyms
- Venoocclusive disease (VOD)
Definitions
- Injury of sinusoidal endothelial cells leading to sinusoidal obstruction and postsinusoidal portal hypertension
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Bonifazi F et al: Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation. Front Immunol. 11:489, 2020
- de Lédinghen V et al: Sinusoidal obstruction syndrome. Clin Res Hepatol Gastroenterol. 44(4):480-5, 2020
- Mahadeo KM et al: Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol. 7(1):e61-72, 2020
- Thumar VD et al: Spectral Doppler ultrasound can help diagnose children with hepatic sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. Ultrasound Q. 36(1):6-14, 2020
- Matsukuma KE et al: Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 7(Suppl 1):S21-31, 2016
- Kambham N et al: Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol. 21(5):301-20, 2014
- Zhou H et al: Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features. Korean J Radiol. 15(2):218-25, 2014
- Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
- Coppell JA et al: Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 16(2):157-68, 2010
- Rubbia-Brandt L: Sinusoidal obstruction syndrome. Clin Liver Dis. 14(4):651-68, 2010
- Chung YE et al: Electronic clinical challenges and images in GI. Hepatic venoocclusive disease. Gastroenterology. 135(1):e3-4, 2008
- Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
- Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
- McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
- van den Bosch MA et al: MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation. Eur Radiol. 10(8):1290-3, 2000
- Lassau N et al: Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients. Radiology. 204(2):545-52, 1997
- McDonald GB et al: Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 118(4):255-67, 1993
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Hepatic sinusoidal obstruction syndrome (SOS)
Synonyms
- Venoocclusive disease (VOD)
Definitions
- Injury of sinusoidal endothelial cells leading to sinusoidal obstruction and postsinusoidal portal hypertension
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Bonifazi F et al: Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation. Front Immunol. 11:489, 2020
- de Lédinghen V et al: Sinusoidal obstruction syndrome. Clin Res Hepatol Gastroenterol. 44(4):480-5, 2020
- Mahadeo KM et al: Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol. 7(1):e61-72, 2020
- Thumar VD et al: Spectral Doppler ultrasound can help diagnose children with hepatic sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. Ultrasound Q. 36(1):6-14, 2020
- Matsukuma KE et al: Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 7(Suppl 1):S21-31, 2016
- Kambham N et al: Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol. 21(5):301-20, 2014
- Zhou H et al: Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features. Korean J Radiol. 15(2):218-25, 2014
- Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
- Coppell JA et al: Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 16(2):157-68, 2010
- Rubbia-Brandt L: Sinusoidal obstruction syndrome. Clin Liver Dis. 14(4):651-68, 2010
- Chung YE et al: Electronic clinical challenges and images in GI. Hepatic venoocclusive disease. Gastroenterology. 135(1):e3-4, 2008
- Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
- Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
- McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
- van den Bosch MA et al: MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation. Eur Radiol. 10(8):1290-3, 2000
- Lassau N et al: Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients. Radiology. 204(2):545-52, 1997
- McDonald GB et al: Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 118(4):255-67, 1993
