link
Bookmarks
Skin Invasion
Jessica W. T. Leung, MD; Wei Tse Yang, MBBS
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
10
4
0

KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Tumor extending into skin directly overlying tumor
            • Peau d'orange = skin resembling orange peel
              • Erythematous; thickened with prominent skin pores
              • Implies lymphatic obstruction and edema
              • Usually seen with inflammatory carcinoma
            • Distinguish from Paget disease
              • Adenocarcinoma cells in epidermis of nipple-areolar complex
              • In situ disease in and of itself

          IMAGING

          • General Features

            • Mammographic Findings

              • Ultrasonographic Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Image-Guided Biopsy

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Amin MB et al: AJCC Cancer Staging Manual. 8th ed. Springer, 2018
                                      2. Edge SB et al: AJCC Cancer Staging Handbook. 7th ed. New York: Springer, 2011
                                      3. Nakamura N et al: Palliative radiotherapy for breast cancer patients with skin invasion: a multi-institutional prospective observational study. Jpn J Clin Oncol. 48(6):555-558, 2018
                                      4. Marta GN et al: Multidisciplinary international survey of post-operative radiation therapy practices after nipple-sparing or skin-sparing mastectomy. Eur J Surg Oncol. 43(11):2036-2043, 2017
                                      5. Lee SC et al: Radiologist's role in breast cancer staging: providing key information for clinicians. Radiographics. 34(2):330-42, 2014
                                      6. Miranda BH et al: Axillary skin malignancy: a rare breast cancer presentation. Ann Plast Surg. 72(5):513-4, 2014
                                      7. Silverman D et al: Skin involvement and breast cancer: are T4b lesions of all sizes created equal? J Am Coll Surg. 219(3):534-44, 2014
                                      8. Agrawal A et al: Skin sparing mastectomy and immediate breast reconstruction: a review. Eur J Surg Oncol. 39(4):320-8, 2013
                                      9. Mazilu L et al: Optimizing the indication for breast-conservative surgery (BCS) in patients with locally-advanced breast cancer. Chirurgia (Bucur). 108(4):478-81, 2013
                                      10. Sanders MA et al: Paget disease of the breast with invasion from nipple skin into the dermis: an unusual type of skin invasion not associated with an adverse outcome. Arch Pathol Lab Med. 137(1):72-6, 2013
                                      11. Fernandez-Flores A: Cutaneous metastases: a study of 78 biopsies from 69 patients. Am J Dermatopathol. 32(3):222-39, 2010
                                      12. Tada K et al: Skin invasion and prognosis in node negative breast cancer: a retrospective study. World J Surg Oncol. 6:10, 2008
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • Tumor extending into skin directly overlying tumor
                                                • Peau d'orange = skin resembling orange peel
                                                  • Erythematous; thickened with prominent skin pores
                                                  • Implies lymphatic obstruction and edema
                                                  • Usually seen with inflammatory carcinoma
                                                • Distinguish from Paget disease
                                                  • Adenocarcinoma cells in epidermis of nipple-areolar complex
                                                  • In situ disease in and of itself

                                              IMAGING

                                              • General Features

                                                • Mammographic Findings

                                                  • Ultrasonographic Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Image-Guided Biopsy

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • Staging, Grading, & Classification

                                                                • Gross Pathologic & Surgical Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Amin MB et al: AJCC Cancer Staging Manual. 8th ed. Springer, 2018
                                                                          2. Edge SB et al: AJCC Cancer Staging Handbook. 7th ed. New York: Springer, 2011
                                                                          3. Nakamura N et al: Palliative radiotherapy for breast cancer patients with skin invasion: a multi-institutional prospective observational study. Jpn J Clin Oncol. 48(6):555-558, 2018
                                                                          4. Marta GN et al: Multidisciplinary international survey of post-operative radiation therapy practices after nipple-sparing or skin-sparing mastectomy. Eur J Surg Oncol. 43(11):2036-2043, 2017
                                                                          5. Lee SC et al: Radiologist's role in breast cancer staging: providing key information for clinicians. Radiographics. 34(2):330-42, 2014
                                                                          6. Miranda BH et al: Axillary skin malignancy: a rare breast cancer presentation. Ann Plast Surg. 72(5):513-4, 2014
                                                                          7. Silverman D et al: Skin involvement and breast cancer: are T4b lesions of all sizes created equal? J Am Coll Surg. 219(3):534-44, 2014
                                                                          8. Agrawal A et al: Skin sparing mastectomy and immediate breast reconstruction: a review. Eur J Surg Oncol. 39(4):320-8, 2013
                                                                          9. Mazilu L et al: Optimizing the indication for breast-conservative surgery (BCS) in patients with locally-advanced breast cancer. Chirurgia (Bucur). 108(4):478-81, 2013
                                                                          10. Sanders MA et al: Paget disease of the breast with invasion from nipple skin into the dermis: an unusual type of skin invasion not associated with an adverse outcome. Arch Pathol Lab Med. 137(1):72-6, 2013
                                                                          11. Fernandez-Flores A: Cutaneous metastases: a study of 78 biopsies from 69 patients. Am J Dermatopathol. 32(3):222-39, 2010
                                                                          12. Tada K et al: Skin invasion and prognosis in node negative breast cancer: a retrospective study. World J Surg Oncol. 6:10, 2008