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Skin Lesions, Other
Stamatia Destounis, MD; Selin Carkaci, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        TERMINOLOGY

        • Definitions

          • Findings related to skin; may mimic breast parenchymal lesions on imaging
            • Most common: Epidermal inclusion cyst, sebaceous cyst, and dermal Ca⁺⁺, considered separately
          • Entities may be isolated, neoplastic, extensions of diffuse cutaneous abnormalities, manifestation of systemic processes, iatrogenic, or traumatic

        IMAGING

        • General Features

          • Mammographic Findings

            • Ultrasonographic Findings

              • MR Findings

                • Nuclear Medicine Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      CLINICAL ISSUES

                      • Natural History & Prognosis

                        • Treatment

                          DIAGNOSTIC CHECKLIST

                          • Consider

                            Selected References

                            1. Lee CI et al: Breast Imaging Rotations in Radiology. New York: Oxford University Press. 394-402, 2018
                            2. Requena L et al: Cutaneous Adnexal Neoplasms. Switzerland: Springer. 2017
                            3. Orta LY et al: Cutaneous/subcutaneous mesenchymal proliferations of the breast. Semin Diagn Pathol. 34(5):470-478, 2017
                            4. Shin SJ. A Comprehensive Guide to Core Needle Biopsies of the Breast. Switzerland: Springer. 853-908, 2016
                            5. Rosen PP et al: Rosen's Breast Pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins. 1217-1237, 2014
                            6. Benveniste AP et al: Benign breast lesions detected by positron emission tomography-computed tomography. Eur J Radiol. 83(6):919-929, 2014
                            7. Cao MM et al: Mammographic signs of systemic disease. Radiographics. 31(4):1085-100, 2011
                            8. Giess CS et al: Distinguishing breast skin lesions from superficial breast parenchymal lesions: diagnostic criteria, imaging characteristics, and pitfalls. Radiographics. 31(7):1959-72, 2011
                            9. Kalli S et al: Lesions of the skin and superficial tissue at breast MR imaging. Radiographics. 30(7):1891-913, 2010
                            10. Alsaad KO et al: Skin adnexal neoplasms--part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol. 60(2):129-44, 2007
                            11. Obaidat NA et al: Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol. 60(2):145-59, 2007
                            12. Kurul S et al: Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of the literature. Jpn J Clin Oncol. 35(4):202-6, 2005
                            13. Millman SL et al: An unusual presentation of neurofibromatosis of the breast. Breast J. 10(1):45-7, 2004
                            14. Murat A et al: Neurofibroma of the breast in a boy with neurofibromatosis type 1. Clin Imaging. 28(6):415-7, 2004
                            15. Wilson CH et al: Gynaecomastia, neurofibromatosis and breast cancer. Breast. 13(1):77-9, 2004
                            16. Park KY et al: Steatocystoma multiplex: mammographic and sonographic manifestations. AJR Am J Roentgenol. 180(1):271-4, 2003
                            17. Operé E et al: Localized scleroderma of the breast. Eur Radiol. 12(6):1483-5, 2002
                            18. Rosen PP: Rosen's Breast Pathology. 2nd ed. Philadelphia: Lippincott williams & Wilkins. 904-12, 2001
                            19. Shetty MK et al: Mondor's disease of the breast: sonographic and mammographic findings. AJR Am J Roentgenol. 177(4):893-6, 2001
                            20. Bassett LW et al: Diagnosis of Diseases of the Breast. Philadelphia: WB Saunders Co. 38-364, 1997
                            21. Denison CM et al: Epidermal inclusion cysts of the breast: three lesions with calcifications. Radiology. 204(2):493-6, 1997
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Top Differential Diagnoses

                                  TERMINOLOGY

                                  • Definitions

                                    • Findings related to skin; may mimic breast parenchymal lesions on imaging
                                      • Most common: Epidermal inclusion cyst, sebaceous cyst, and dermal Ca⁺⁺, considered separately
                                    • Entities may be isolated, neoplastic, extensions of diffuse cutaneous abnormalities, manifestation of systemic processes, iatrogenic, or traumatic

                                  IMAGING

                                  • General Features

                                    • Mammographic Findings

                                      • Ultrasonographic Findings

                                        • MR Findings

                                          • Nuclear Medicine Findings

                                            • Imaging Recommendations

                                              DIFFERENTIAL DIAGNOSIS

                                                CLINICAL ISSUES

                                                • Natural History & Prognosis

                                                  • Treatment

                                                    DIAGNOSTIC CHECKLIST

                                                    • Consider

                                                      Selected References

                                                      1. Lee CI et al: Breast Imaging Rotations in Radiology. New York: Oxford University Press. 394-402, 2018
                                                      2. Requena L et al: Cutaneous Adnexal Neoplasms. Switzerland: Springer. 2017
                                                      3. Orta LY et al: Cutaneous/subcutaneous mesenchymal proliferations of the breast. Semin Diagn Pathol. 34(5):470-478, 2017
                                                      4. Shin SJ. A Comprehensive Guide to Core Needle Biopsies of the Breast. Switzerland: Springer. 853-908, 2016
                                                      5. Rosen PP et al: Rosen's Breast Pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins. 1217-1237, 2014
                                                      6. Benveniste AP et al: Benign breast lesions detected by positron emission tomography-computed tomography. Eur J Radiol. 83(6):919-929, 2014
                                                      7. Cao MM et al: Mammographic signs of systemic disease. Radiographics. 31(4):1085-100, 2011
                                                      8. Giess CS et al: Distinguishing breast skin lesions from superficial breast parenchymal lesions: diagnostic criteria, imaging characteristics, and pitfalls. Radiographics. 31(7):1959-72, 2011
                                                      9. Kalli S et al: Lesions of the skin and superficial tissue at breast MR imaging. Radiographics. 30(7):1891-913, 2010
                                                      10. Alsaad KO et al: Skin adnexal neoplasms--part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol. 60(2):129-44, 2007
                                                      11. Obaidat NA et al: Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol. 60(2):145-59, 2007
                                                      12. Kurul S et al: Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of the literature. Jpn J Clin Oncol. 35(4):202-6, 2005
                                                      13. Millman SL et al: An unusual presentation of neurofibromatosis of the breast. Breast J. 10(1):45-7, 2004
                                                      14. Murat A et al: Neurofibroma of the breast in a boy with neurofibromatosis type 1. Clin Imaging. 28(6):415-7, 2004
                                                      15. Wilson CH et al: Gynaecomastia, neurofibromatosis and breast cancer. Breast. 13(1):77-9, 2004
                                                      16. Park KY et al: Steatocystoma multiplex: mammographic and sonographic manifestations. AJR Am J Roentgenol. 180(1):271-4, 2003
                                                      17. Operé E et al: Localized scleroderma of the breast. Eur Radiol. 12(6):1483-5, 2002
                                                      18. Rosen PP: Rosen's Breast Pathology. 2nd ed. Philadelphia: Lippincott williams & Wilkins. 904-12, 2001
                                                      19. Shetty MK et al: Mondor's disease of the breast: sonographic and mammographic findings. AJR Am J Roentgenol. 177(4):893-6, 2001
                                                      20. Bassett LW et al: Diagnosis of Diseases of the Breast. Philadelphia: WB Saunders Co. 38-364, 1997
                                                      21. Denison CM et al: Epidermal inclusion cysts of the breast: three lesions with calcifications. Radiology. 204(2):493-6, 1997