link
Bookmarks
Skull Base Chondrosarcoma
Surjith Vattoth, MD, FRCR; Philip R. Chapman, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
14
18
14

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Chondrosarcoma-skull base (CSA-SB)
              • Definitions

                • CSA-SB: Chondroid malignancy of skull base

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Weber DC et al: Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy. Radiother Oncol. 129(3):520-52, 2018
                                              2. Welzel T et al: Diagnostic accuracy of DW MR imaging in the differentiation of chordomas and chondrosarcomas of the skull base: A 3.0-T MRI study of 105 cases. Eur J Radiol. 105:119-24, 2018
                                              3. Awad M et al: Skull base chondrosarcoma. J Clin Neurosci. 24:1-5, 2016
                                              4. Heo J et al: A case of giant skull base chondroma. Brain Tumor Res Treat. 2(2):92-5, 2014
                                              5. Bag AK et al: Neuroimaging: intrinsic lesions of the central skull base region. Semin Ultrasound CT MR. 34(5):412-35, 2013
                                              6. Bloch O et al: Skull base chondrosarcoma: evidence-based treatment paradigms. Neurosurg Clin N Am. 24(1):89-96, 2013
                                              7. Gardner PA et al: Carotid artery injury during endoscopic endonasal skull base surgery: incidence and outcomes. Neurosurgery. 73(2 Suppl Operative):ons261-9; discussion ons269-70, 2013
                                              8. Sbaihat A et al: Skull base chondrosarcomas: surgical treatment and results. Ann Otol Rhinol Laryngol. 122(12):763-70, 2013
                                              9. Amichetti M et al: A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. Neurosurg Rev. 33(2):155-65, 2010
                                              10. Bloch OG et al: Cranial chondrosarcoma and recurrence. Skull Base. 20(3):149-56, 2010
                                              11. Ares C et al: Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 75(4):1111-8, 2009
                                              12. Borges A: Imaging of the central skull base. Neuroimaging Clin N Am. 19(4):669-96, 2009
                                              13. Gallia GL et al: Skull base chondrosarcoma presenting with hemorrhage. Can J Neurol Sci. 36(6):774-5, 2009
                                              14. Güneş M et al: Intracranial chondrosarcoma: a case report and review of the literature. Minim Invasive Neurosurg. 52(5-6):238-41, 2009
                                              15. Hong P et al: Chondrosarcoma of the head and neck: report of 11 cases and literature review. J Otolaryngol Head Neck Surg. 38(2):279-85, 2009
                                              16. Samii A et al: Surgical treatment of skull base chondrosarcomas. Neurosurg Rev. 32(1):67-75; discussion 75, 2009
                                              17. Abdelmalek M et al: Recurrent chondrosarcoma of the right skull base in a patient with Maffucci syndrome. Am J Clin Dermatol. 9(1):61-5, 2008
                                              18. Cho YH et al: Chordomas and chondrosarcomas of the skull base: comparative analysis of clinical results in 30 patients. Neurosurg Rev. 31(1):35-43; discussion 43, 2008
                                              19. Ferrer Pérez AI et al: Skull base chondrosarcoma: a case treated by the CyberKnife system. Clin Transl Oncol. 10(10):670-2, 2008
                                              20. Gelderblom H et al: The clinical approach towards chondrosarcoma. Oncologist. 2008 Mar;13(3):320-9. Review. Erratum in: Oncologist. 13(5):618, 2008
                                              21. Nguyen QN et al: Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 10(4):338-43, 2008
                                              22. Sanna M et al: Chondrosarcomas of the jugular foramen. Laryngoscope. 118(10):1719-28, 2008
                                              23. Seizeur R et al: Chondrosarcoma of the skull base in Maffucci's syndrome. Br J Neurosurg. 22(6):778-80, 2008
                                              24. Zhang Q et al: Endoscopic endonasal surgery for clival chordoma and chondrosarcoma. ORL J Otorhinolaryngol Relat Spec. 70(2):124-9, 2008
                                              25. Almefty K et al: Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer. 110(11):2457-67, 2007
                                              26. Dini LI et al: Maffucci's syndrome complicated by intracranial chondrosarcoma: two new illustrative cases. Arq Neuropsiquiatr. 65(3B):816-21, 2007
                                              27. Lustig LR et al: Chondrosarcomas of the skull base and temporal bone. J Laryngol Otol. 121(8):725-35, 2007
                                              28. Schulz-Ertner D et al: Carbon ion radiotherapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys. 67(1):171-7, 2007
                                              29. Baehring JM et al: Chondrosarcoma of the skull base. J Neurooncol. 76(1):49, 2006
                                              30. Brackmann DE et al: Chondrosarcoma of the skull base: long-term follow-up. Otol Neurotol. 27(7):981-91, 2006
                                              31. Frank G et al: The endoscopic transnasal transsphenoidal approach for the treatment of cranial base chordomas and chondrosarcomas. Neurosurgery. 59(1 Suppl 1):ONS50-7; discussion ONS50-7, 2006
                                              32. Harada K et al: Chondrosarcoma of the clivus presenting with intratumoral hemorrhage: case report. J Neurooncol. 77(2):221-3, 2006
                                              33. Tzortzidis F et al: Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chondrosarcomas. Neurosurgery. 58(6):1090-8; discussion 1090-8, 2006
                                              34. Krishnan S et al: Radiosurgery for cranial base chordomas and chondrosarcomas. Neurosurgery. 56(4):777-84; discussion 777-84, 2005
                                              35. Oghalai JS et al: Skull base chondrosarcoma originating from the petroclival junction. Otol Neurotol. 26(5):1052-60, 2005
                                              36. Noël G et al: Chondrosarcomas of the base of the skull in Ollier's disease or Maffucci's syndrome--three case reports and review of the literature. Acta Oncol. 43(8):705-10, 2004
                                              37. Raghu M et al: Chondrosarcomas of the temporal bone: presentation and management. J Laryngol Otol. 118(7):551-5, 2004
                                              38. Neff B et al: Chondrosarcoma of the skull base. Laryngoscope. 112(1):134-9, 2002
                                              39. Schmidinger A et al: Natural history of chondroid skull base lesions--case report and review. Neuroradiology. 44(3):268-71, 2002
                                              40. Crockard HA et al: A multidisciplinary team approach to skull base chondrosarcomas. J Neurosurg. 95(2):184-9, 2001
                                              41. Richardson MS: Pathology of skull base tumors. Otolaryngol Clin North Am. 34(6):1025-42, vii, 2001
                                              42. Hug EB et al: Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 91(3):432-9, 1999
                                              43. Rosenberg AE et al: Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 23(11):1370-8, 1999
                                              44. Korten AG et al: Intracranial chondrosarcoma: review of the literature and report of 15 cases. J Neurol Neurosurg Psychiatry. 65(1):88-92, 1998
                                              45. Keel SB et al: Chondromyxoid fibroma of the skull base: a tumor which may be confused with chordoma and chondrosarcoma. A report of three cases and review of the literature. Am J Surg Pathol. 21(5):577-82, 1997
                                              46. Ramina R et al: Maffucci's syndrome associated with a cranial base chondrosarcoma: case report and literature review. Neurosurgery. 41(1):269-72, 1997
                                              47. Rapidis AD et al: Chondrosarcomas of the skull base: review of the literature and report of two cases. J Craniomaxillofac Surg. 25(6):322-7, 1997
                                              48. Geirnaerdt MJ et al: Calcified meningioma of the skull base simulating chondrosarcoma. Eur J Radiol. 21(2):148-51, 1995
                                              49. Weber AL et al: Cartilaginous tumors and chordomas of the cranial base. Otolaryngol Clin North Am. 28(3):453-71, 1995
                                              50. Brown E et al: Chondrosarcoma of the skull base. Neuroimaging Clin N Am. 4(3):529-41, 1994
                                              51. Stapleton SR et al: Chondrosarcoma of the skull base: a series of eight cases. Neurosurgery. 32(3):348-55; discussion 355-6, 1993
                                              52. Meyers SP et al: Chondrosarcomas of the skull base: MR imaging features. Radiology. 184(1):103-8, 1992
                                              53. Kveton JF et al: Chondrosarcoma of the skull base. Otolaryngol Head Neck Surg. 94(1):23-32, 1986
                                              Related Anatomy
                                              Loading...
                                              Related Differential Diagnoses
                                              Loading...
                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Chondrosarcoma-skull base (CSA-SB)
                                                          • Definitions

                                                            • CSA-SB: Chondroid malignancy of skull base

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Angiographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Weber DC et al: Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy. Radiother Oncol. 129(3):520-52, 2018
                                                                                          2. Welzel T et al: Diagnostic accuracy of DW MR imaging in the differentiation of chordomas and chondrosarcomas of the skull base: A 3.0-T MRI study of 105 cases. Eur J Radiol. 105:119-24, 2018
                                                                                          3. Awad M et al: Skull base chondrosarcoma. J Clin Neurosci. 24:1-5, 2016
                                                                                          4. Heo J et al: A case of giant skull base chondroma. Brain Tumor Res Treat. 2(2):92-5, 2014
                                                                                          5. Bag AK et al: Neuroimaging: intrinsic lesions of the central skull base region. Semin Ultrasound CT MR. 34(5):412-35, 2013
                                                                                          6. Bloch O et al: Skull base chondrosarcoma: evidence-based treatment paradigms. Neurosurg Clin N Am. 24(1):89-96, 2013
                                                                                          7. Gardner PA et al: Carotid artery injury during endoscopic endonasal skull base surgery: incidence and outcomes. Neurosurgery. 73(2 Suppl Operative):ons261-9; discussion ons269-70, 2013
                                                                                          8. Sbaihat A et al: Skull base chondrosarcomas: surgical treatment and results. Ann Otol Rhinol Laryngol. 122(12):763-70, 2013
                                                                                          9. Amichetti M et al: A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. Neurosurg Rev. 33(2):155-65, 2010
                                                                                          10. Bloch OG et al: Cranial chondrosarcoma and recurrence. Skull Base. 20(3):149-56, 2010
                                                                                          11. Ares C et al: Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 75(4):1111-8, 2009
                                                                                          12. Borges A: Imaging of the central skull base. Neuroimaging Clin N Am. 19(4):669-96, 2009
                                                                                          13. Gallia GL et al: Skull base chondrosarcoma presenting with hemorrhage. Can J Neurol Sci. 36(6):774-5, 2009
                                                                                          14. Güneş M et al: Intracranial chondrosarcoma: a case report and review of the literature. Minim Invasive Neurosurg. 52(5-6):238-41, 2009
                                                                                          15. Hong P et al: Chondrosarcoma of the head and neck: report of 11 cases and literature review. J Otolaryngol Head Neck Surg. 38(2):279-85, 2009
                                                                                          16. Samii A et al: Surgical treatment of skull base chondrosarcomas. Neurosurg Rev. 32(1):67-75; discussion 75, 2009
                                                                                          17. Abdelmalek M et al: Recurrent chondrosarcoma of the right skull base in a patient with Maffucci syndrome. Am J Clin Dermatol. 9(1):61-5, 2008
                                                                                          18. Cho YH et al: Chordomas and chondrosarcomas of the skull base: comparative analysis of clinical results in 30 patients. Neurosurg Rev. 31(1):35-43; discussion 43, 2008
                                                                                          19. Ferrer Pérez AI et al: Skull base chondrosarcoma: a case treated by the CyberKnife system. Clin Transl Oncol. 10(10):670-2, 2008
                                                                                          20. Gelderblom H et al: The clinical approach towards chondrosarcoma. Oncologist. 2008 Mar;13(3):320-9. Review. Erratum in: Oncologist. 13(5):618, 2008
                                                                                          21. Nguyen QN et al: Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 10(4):338-43, 2008
                                                                                          22. Sanna M et al: Chondrosarcomas of the jugular foramen. Laryngoscope. 118(10):1719-28, 2008
                                                                                          23. Seizeur R et al: Chondrosarcoma of the skull base in Maffucci's syndrome. Br J Neurosurg. 22(6):778-80, 2008
                                                                                          24. Zhang Q et al: Endoscopic endonasal surgery for clival chordoma and chondrosarcoma. ORL J Otorhinolaryngol Relat Spec. 70(2):124-9, 2008
                                                                                          25. Almefty K et al: Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer. 110(11):2457-67, 2007
                                                                                          26. Dini LI et al: Maffucci's syndrome complicated by intracranial chondrosarcoma: two new illustrative cases. Arq Neuropsiquiatr. 65(3B):816-21, 2007
                                                                                          27. Lustig LR et al: Chondrosarcomas of the skull base and temporal bone. J Laryngol Otol. 121(8):725-35, 2007
                                                                                          28. Schulz-Ertner D et al: Carbon ion radiotherapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys. 67(1):171-7, 2007
                                                                                          29. Baehring JM et al: Chondrosarcoma of the skull base. J Neurooncol. 76(1):49, 2006
                                                                                          30. Brackmann DE et al: Chondrosarcoma of the skull base: long-term follow-up. Otol Neurotol. 27(7):981-91, 2006
                                                                                          31. Frank G et al: The endoscopic transnasal transsphenoidal approach for the treatment of cranial base chordomas and chondrosarcomas. Neurosurgery. 59(1 Suppl 1):ONS50-7; discussion ONS50-7, 2006
                                                                                          32. Harada K et al: Chondrosarcoma of the clivus presenting with intratumoral hemorrhage: case report. J Neurooncol. 77(2):221-3, 2006
                                                                                          33. Tzortzidis F et al: Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chondrosarcomas. Neurosurgery. 58(6):1090-8; discussion 1090-8, 2006
                                                                                          34. Krishnan S et al: Radiosurgery for cranial base chordomas and chondrosarcomas. Neurosurgery. 56(4):777-84; discussion 777-84, 2005
                                                                                          35. Oghalai JS et al: Skull base chondrosarcoma originating from the petroclival junction. Otol Neurotol. 26(5):1052-60, 2005
                                                                                          36. Noël G et al: Chondrosarcomas of the base of the skull in Ollier's disease or Maffucci's syndrome--three case reports and review of the literature. Acta Oncol. 43(8):705-10, 2004
                                                                                          37. Raghu M et al: Chondrosarcomas of the temporal bone: presentation and management. J Laryngol Otol. 118(7):551-5, 2004
                                                                                          38. Neff B et al: Chondrosarcoma of the skull base. Laryngoscope. 112(1):134-9, 2002
                                                                                          39. Schmidinger A et al: Natural history of chondroid skull base lesions--case report and review. Neuroradiology. 44(3):268-71, 2002
                                                                                          40. Crockard HA et al: A multidisciplinary team approach to skull base chondrosarcomas. J Neurosurg. 95(2):184-9, 2001
                                                                                          41. Richardson MS: Pathology of skull base tumors. Otolaryngol Clin North Am. 34(6):1025-42, vii, 2001
                                                                                          42. Hug EB et al: Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 91(3):432-9, 1999
                                                                                          43. Rosenberg AE et al: Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 23(11):1370-8, 1999
                                                                                          44. Korten AG et al: Intracranial chondrosarcoma: review of the literature and report of 15 cases. J Neurol Neurosurg Psychiatry. 65(1):88-92, 1998
                                                                                          45. Keel SB et al: Chondromyxoid fibroma of the skull base: a tumor which may be confused with chordoma and chondrosarcoma. A report of three cases and review of the literature. Am J Surg Pathol. 21(5):577-82, 1997
                                                                                          46. Ramina R et al: Maffucci's syndrome associated with a cranial base chondrosarcoma: case report and literature review. Neurosurgery. 41(1):269-72, 1997
                                                                                          47. Rapidis AD et al: Chondrosarcomas of the skull base: review of the literature and report of two cases. J Craniomaxillofac Surg. 25(6):322-7, 1997
                                                                                          48. Geirnaerdt MJ et al: Calcified meningioma of the skull base simulating chondrosarcoma. Eur J Radiol. 21(2):148-51, 1995
                                                                                          49. Weber AL et al: Cartilaginous tumors and chordomas of the cranial base. Otolaryngol Clin North Am. 28(3):453-71, 1995
                                                                                          50. Brown E et al: Chondrosarcoma of the skull base. Neuroimaging Clin N Am. 4(3):529-41, 1994
                                                                                          51. Stapleton SR et al: Chondrosarcoma of the skull base: a series of eight cases. Neurosurgery. 32(3):348-55; discussion 355-6, 1993
                                                                                          52. Meyers SP et al: Chondrosarcomas of the skull base: MR imaging features. Radiology. 184(1):103-8, 1992
                                                                                          53. Kveton JF et al: Chondrosarcoma of the skull base. Otolaryngol Head Neck Surg. 94(1):23-32, 1986