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Skull Base Giant Cell Tumor
Daniel E. Meltzer, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Giant cell tumor (GCT)
              • Synonyms

                • Osteoclastoma
              • Definitions

                • Benign intraosseous neoplasm featuring multinucleated giant cells

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Billingsley JT et al: A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 75(1):e175-9, 2014
                                            2. Prasad SC et al: Giant cell tumors of the skull base: case series and current concepts. Audiol Neurootol. 19(1):12-21, 2014
                                            3. Chakarun CJ et al: Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 33(1):197-211, 2013
                                            4. Kim Y et al: Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clin Orthop Surg. 4(2):107-16, 2012
                                            5. Isaacson B et al: Giant-cell tumors of the temporal bone: management strategies. Skull Base. 19(4):291-301, 2009
                                            6. Pelaz AC et al: Giant cell tumor of the greater wing of the sphenoid: an unusual presentation. J Craniofac Surg. 19(3):822-6, 2008
                                            7. Kashiwagi N et al: MRI and CT findings of the giant cell tumors of the skull; five cases and a review of the literature. Eur J Radiol. 58(3):435-43, 2006
                                            8. Lee MY et al: Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear. J Craniofac Surg. 17(4):797-800, 2006
                                            9. McKinney AM et al: Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation. AJNR Am J Neuroradiol. 27(10):2199-201, 2006
                                            10. Wang Y et al: Giant cell tumor at the lateral skull base. Am J Otolaryngol. 27(1):64-7, 2006
                                            11. Chan J et al: Malignant giant cell tumor of the sphenoid. Ann Diagn Pathol. 7(2):100-5, 2003
                                            12. Ito H et al: Secondary aneurysmal bone cyst derived from a giant-cell tumour of the skull base. Neuroradiology. 45(9):616-7, 2003
                                            13. Tang JY et al: MRI appearance of giant cell tumor of the lateral skull base: a case report. Clin Imaging. 27(1):27-30, 2003
                                            14. Hug EB et al: 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol. 178(5):239-44, 2002
                                            15. Sharma RR et al: Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 9(1):41-50, 2002
                                            16. Kaban LB et al: Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics. 103(6 Pt 1):1145-9, 1999
                                            17. Lee HJ et al: Giant-cell tumor of the skull base. Neuroradiology. 41(4):305-7, 1999
                                            18. Sheikh M et al: Giant cell tumour of the temporal bone: case report and review of the literature. Australas Radiol. 43(1):113-5, 1999
                                            19. Rimmelin A et al: Giant-cell tumour of the sphenoid bone: case report. Neuroradiology. 38(7):650-3, 1996
                                            20. Silvers AR et al: The role of imaging in the diagnosis of giant cell tumor of the skull base. AJNR Am J Neuroradiol. 17(7):1392-5, 1996
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Giant cell tumor (GCT)
                                                        • Synonyms

                                                          • Osteoclastoma
                                                        • Definitions

                                                          • Benign intraosseous neoplasm featuring multinucleated giant cells

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Billingsley JT et al: A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 75(1):e175-9, 2014
                                                                                      2. Prasad SC et al: Giant cell tumors of the skull base: case series and current concepts. Audiol Neurootol. 19(1):12-21, 2014
                                                                                      3. Chakarun CJ et al: Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 33(1):197-211, 2013
                                                                                      4. Kim Y et al: Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clin Orthop Surg. 4(2):107-16, 2012
                                                                                      5. Isaacson B et al: Giant-cell tumors of the temporal bone: management strategies. Skull Base. 19(4):291-301, 2009
                                                                                      6. Pelaz AC et al: Giant cell tumor of the greater wing of the sphenoid: an unusual presentation. J Craniofac Surg. 19(3):822-6, 2008
                                                                                      7. Kashiwagi N et al: MRI and CT findings of the giant cell tumors of the skull; five cases and a review of the literature. Eur J Radiol. 58(3):435-43, 2006
                                                                                      8. Lee MY et al: Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear. J Craniofac Surg. 17(4):797-800, 2006
                                                                                      9. McKinney AM et al: Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation. AJNR Am J Neuroradiol. 27(10):2199-201, 2006
                                                                                      10. Wang Y et al: Giant cell tumor at the lateral skull base. Am J Otolaryngol. 27(1):64-7, 2006
                                                                                      11. Chan J et al: Malignant giant cell tumor of the sphenoid. Ann Diagn Pathol. 7(2):100-5, 2003
                                                                                      12. Ito H et al: Secondary aneurysmal bone cyst derived from a giant-cell tumour of the skull base. Neuroradiology. 45(9):616-7, 2003
                                                                                      13. Tang JY et al: MRI appearance of giant cell tumor of the lateral skull base: a case report. Clin Imaging. 27(1):27-30, 2003
                                                                                      14. Hug EB et al: 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol. 178(5):239-44, 2002
                                                                                      15. Sharma RR et al: Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 9(1):41-50, 2002
                                                                                      16. Kaban LB et al: Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics. 103(6 Pt 1):1145-9, 1999
                                                                                      17. Lee HJ et al: Giant-cell tumor of the skull base. Neuroradiology. 41(4):305-7, 1999
                                                                                      18. Sheikh M et al: Giant cell tumour of the temporal bone: case report and review of the literature. Australas Radiol. 43(1):113-5, 1999
                                                                                      19. Rimmelin A et al: Giant-cell tumour of the sphenoid bone: case report. Neuroradiology. 38(7):650-3, 1996
                                                                                      20. Silvers AR et al: The role of imaging in the diagnosis of giant cell tumor of the skull base. AJNR Am J Neuroradiol. 17(7):1392-5, 1996