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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Giant cell tumor (GCT)
Synonyms
- Osteoclastoma
Definitions
- Benign intraosseous neoplasm featuring multinucleated giant cells
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Billingsley JT et al: A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 75(1):e175-9, 2014
- Prasad SC et al: Giant cell tumors of the skull base: case series and current concepts. Audiol Neurootol. 19(1):12-21, 2014
- Chakarun CJ et al: Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 33(1):197-211, 2013
- Kim Y et al: Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clin Orthop Surg. 4(2):107-16, 2012
- Isaacson B et al: Giant-cell tumors of the temporal bone: management strategies. Skull Base. 19(4):291-301, 2009
- Pelaz AC et al: Giant cell tumor of the greater wing of the sphenoid: an unusual presentation. J Craniofac Surg. 19(3):822-6, 2008
- Kashiwagi N et al: MRI and CT findings of the giant cell tumors of the skull; five cases and a review of the literature. Eur J Radiol. 58(3):435-43, 2006
- Lee MY et al: Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear. J Craniofac Surg. 17(4):797-800, 2006
- McKinney AM et al: Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation. AJNR Am J Neuroradiol. 27(10):2199-201, 2006
- Wang Y et al: Giant cell tumor at the lateral skull base. Am J Otolaryngol. 27(1):64-7, 2006
- Chan J et al: Malignant giant cell tumor of the sphenoid. Ann Diagn Pathol. 7(2):100-5, 2003
- Ito H et al: Secondary aneurysmal bone cyst derived from a giant-cell tumour of the skull base. Neuroradiology. 45(9):616-7, 2003
- Tang JY et al: MRI appearance of giant cell tumor of the lateral skull base: a case report. Clin Imaging. 27(1):27-30, 2003
- Hug EB et al: 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol. 178(5):239-44, 2002
- Sharma RR et al: Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 9(1):41-50, 2002
- Kaban LB et al: Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics. 103(6 Pt 1):1145-9, 1999
- Lee HJ et al: Giant-cell tumor of the skull base. Neuroradiology. 41(4):305-7, 1999
- Sheikh M et al: Giant cell tumour of the temporal bone: case report and review of the literature. Australas Radiol. 43(1):113-5, 1999
- Rimmelin A et al: Giant-cell tumour of the sphenoid bone: case report. Neuroradiology. 38(7):650-3, 1996
- Silvers AR et al: The role of imaging in the diagnosis of giant cell tumor of the skull base. AJNR Am J Neuroradiol. 17(7):1392-5, 1996
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Giant cell tumor (GCT)
Synonyms
- Osteoclastoma
Definitions
- Benign intraosseous neoplasm featuring multinucleated giant cells
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Billingsley JT et al: A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 75(1):e175-9, 2014
- Prasad SC et al: Giant cell tumors of the skull base: case series and current concepts. Audiol Neurootol. 19(1):12-21, 2014
- Chakarun CJ et al: Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 33(1):197-211, 2013
- Kim Y et al: Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clin Orthop Surg. 4(2):107-16, 2012
- Isaacson B et al: Giant-cell tumors of the temporal bone: management strategies. Skull Base. 19(4):291-301, 2009
- Pelaz AC et al: Giant cell tumor of the greater wing of the sphenoid: an unusual presentation. J Craniofac Surg. 19(3):822-6, 2008
- Kashiwagi N et al: MRI and CT findings of the giant cell tumors of the skull; five cases and a review of the literature. Eur J Radiol. 58(3):435-43, 2006
- Lee MY et al: Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear. J Craniofac Surg. 17(4):797-800, 2006
- McKinney AM et al: Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation. AJNR Am J Neuroradiol. 27(10):2199-201, 2006
- Wang Y et al: Giant cell tumor at the lateral skull base. Am J Otolaryngol. 27(1):64-7, 2006
- Chan J et al: Malignant giant cell tumor of the sphenoid. Ann Diagn Pathol. 7(2):100-5, 2003
- Ito H et al: Secondary aneurysmal bone cyst derived from a giant-cell tumour of the skull base. Neuroradiology. 45(9):616-7, 2003
- Tang JY et al: MRI appearance of giant cell tumor of the lateral skull base: a case report. Clin Imaging. 27(1):27-30, 2003
- Hug EB et al: 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol. 178(5):239-44, 2002
- Sharma RR et al: Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 9(1):41-50, 2002
- Kaban LB et al: Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics. 103(6 Pt 1):1145-9, 1999
- Lee HJ et al: Giant-cell tumor of the skull base. Neuroradiology. 41(4):305-7, 1999
- Sheikh M et al: Giant cell tumour of the temporal bone: case report and review of the literature. Australas Radiol. 43(1):113-5, 1999
- Rimmelin A et al: Giant-cell tumour of the sphenoid bone: case report. Neuroradiology. 38(7):650-3, 1996
- Silvers AR et al: The role of imaging in the diagnosis of giant cell tumor of the skull base. AJNR Am J Neuroradiol. 17(7):1392-5, 1996
