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Skull Base Multiple Myeloma
Philip R. Chapman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Multiple myeloma (MM)
            • Synonyms

              • Malignant plasmacytoma, diffuse myelomatosis
            • Definitions

              • Multiple myeloma (MM) is malignant monoclonal plasma cell neoplasm of bone marrow

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Giles SL et al: Assessing myeloma bone disease with whole-body diffusion-weighted imaging: comparison with x-ray skeletal survey by region and relationship with laboratory estimates of disease burden. Clin Radiol. 70(6):614-21, 2015
                                                  2. Lasocki A et al: Intracranial involvement by multiple myeloma. Clin Radiol. 70(8):890-7, 2015
                                                  3. Messiou C et al: Whole body diffusion weighted MRI--a new view of myeloma. Br J Haematol. 171(1):29-37, 2015
                                                  4. Sachpekidis C et al: Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma. Am J Nucl Med Mol Imaging. 5(5):469-78, 2015
                                                  5. Giles SL et al: Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma. Radiology. 271(3):785-94, 2014
                                                  6. Gürbüz MS et al: Solitary plasmocytoma of the skull. BMJ Case Rep. 2013, 2013
                                                  7. Joshi A et al: Skull base presentation of multiple myeloma. Ear Nose Throat J. 90(1):E6-9, 2011
                                                  8. Pahade JK et al: Incidence of contrast-induced nephropathy in patients with multiple myeloma undergoing contrast-enhanced CT. AJR Am J Roentgenol. 196(5):1094-101, 2011
                                                  9. Lin C et al: Multiple myeloma treatment response assessment with whole-body dynamic contrast-enhanced MR imaging. Radiology. 254(2):521-31, 2010
                                                  10. Palumbo A et al: Multiple myeloma: chemotherapy or transplantation in the era of new drugs. Eur J Haematol. Epub ahead of print, 2010
                                                  11. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                                  12. Kyle RA et al: Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 23(1):3-9, 2009
                                                  13. Lütje S et al: Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma. Ann Hematol. 88(12):1161-8, 2009
                                                  14. Shortt CP et al: Whole-Body MRI versus PET in assessment of multiple myeloma disease activity. AJR Am J Roentgenol. 192(4):980-6, 2009
                                                  15. Baur-Melnyk A et al: Role of MRI for the diagnosis and prognosis of multiple myeloma. Eur J Radiol. 55(1):56-63, 2005
                                                  16. Bradella MA et al: Value of FDG PET in the assessment of patients with multiple myeloma. Am J Roentgenol. 184 (4):1199-204, 2005
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Multiple myeloma (MM)
                                                            • Synonyms

                                                              • Malignant plasmacytoma, diffuse myelomatosis
                                                            • Definitions

                                                              • Multiple myeloma (MM) is malignant monoclonal plasma cell neoplasm of bone marrow

                                                            IMAGING

                                                            • General Features

                                                              • Imaging Recommendations

                                                                • Radiographic Findings

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Giles SL et al: Assessing myeloma bone disease with whole-body diffusion-weighted imaging: comparison with x-ray skeletal survey by region and relationship with laboratory estimates of disease burden. Clin Radiol. 70(6):614-21, 2015
                                                                                                  2. Lasocki A et al: Intracranial involvement by multiple myeloma. Clin Radiol. 70(8):890-7, 2015
                                                                                                  3. Messiou C et al: Whole body diffusion weighted MRI--a new view of myeloma. Br J Haematol. 171(1):29-37, 2015
                                                                                                  4. Sachpekidis C et al: Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma. Am J Nucl Med Mol Imaging. 5(5):469-78, 2015
                                                                                                  5. Giles SL et al: Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma. Radiology. 271(3):785-94, 2014
                                                                                                  6. Gürbüz MS et al: Solitary plasmocytoma of the skull. BMJ Case Rep. 2013, 2013
                                                                                                  7. Joshi A et al: Skull base presentation of multiple myeloma. Ear Nose Throat J. 90(1):E6-9, 2011
                                                                                                  8. Pahade JK et al: Incidence of contrast-induced nephropathy in patients with multiple myeloma undergoing contrast-enhanced CT. AJR Am J Roentgenol. 196(5):1094-101, 2011
                                                                                                  9. Lin C et al: Multiple myeloma treatment response assessment with whole-body dynamic contrast-enhanced MR imaging. Radiology. 254(2):521-31, 2010
                                                                                                  10. Palumbo A et al: Multiple myeloma: chemotherapy or transplantation in the era of new drugs. Eur J Haematol. Epub ahead of print, 2010
                                                                                                  11. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                                                                                  12. Kyle RA et al: Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 23(1):3-9, 2009
                                                                                                  13. Lütje S et al: Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma. Ann Hematol. 88(12):1161-8, 2009
                                                                                                  14. Shortt CP et al: Whole-Body MRI versus PET in assessment of multiple myeloma disease activity. AJR Am J Roentgenol. 192(4):980-6, 2009
                                                                                                  15. Baur-Melnyk A et al: Role of MRI for the diagnosis and prognosis of multiple myeloma. Eur J Radiol. 55(1):56-63, 2005
                                                                                                  16. Bradella MA et al: Value of FDG PET in the assessment of patients with multiple myeloma. Am J Roentgenol. 184 (4):1199-204, 2005