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Skull Base Osteosarcoma
Philip R. Chapman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Osteosarcoma of skull base (OSa-SB)
            • Definitions

              • Neoplasm composed of malignant spindle cells producing osteoid or immature bone

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Ahrari A et al: Primary osteosarcoma of the skull base treated with endoscopic endonasal approach: a case report and literature review. J Neurol Surg Rep. 76(2):e270-4, 2015
                                    2. Koyama M et al: Radiation-induced osteosarcoma might mimic metastatic bone lesions: a case with bone scan and FDG PET/CT imaging. Clin Nucl Med. 40(5):427-9, 2015
                                    3. Hadley C et al: Osteosarcoma of the cranial vault and skull base in pediatric patients. J Neurosurg Pediatr. 13(4):380-7, 2014
                                    4. Mohindra S et al: Primary osteosarcoma of clivus: a short report. Br J Neurosurg. 28(4):531-3, 2014
                                    5. Sun TT et al: Spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia: clinical and computed tomographic features in 8 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 118(1):e24-31, 2014
                                    6. O'Neill JP et al: Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am. 24(1):67-78, 2013
                                    7. Meel R et al: Childhood osteosarcoma of greater wing of sphenoid: case report and review of literature. J Pediatr Hematol Oncol. 34(2):e59-62, 2012
                                    8. Ottaviani G et al: The etiology of osteosarcoma. Cancer Treat Res. 152:15-32, 2010
                                    9. Chennupati SK et al: Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol. 72(1):115-9, 2008
                                    10. Haddad H et al: [Osteosarcoma of the skull base: a case report.] Neurochirurgie. 53(6):483-5, 2007
                                    11. Hristov B et al: The role of radiation treatment in the contemporary management of bone tumors. J Natl Compr Canc Netw. 5(4):456-66, 2007
                                    12. Ghule P et al: p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. Med Sci Monit. 12(12):BR385-396, 2006
                                    13. Hansen MR et al: Osteosarcoma of the skull base after radiation therapy in a patient with McCune-Albright syndrome: case report. Skull Base. 13(2):79-83, 2003
                                    14. Matsumoto H et al: Novel germline mutation in the RB1 gene with multifocal bone tumors following retinoblastoma. Pediatr Int. 45(6):728-30, 2003
                                    15. Patiño-García A et al: Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. J Pediatr Hematol Oncol. 25(5):362-7, 2003
                                    16. Smith RB et al: National Cancer Data Base report on osteosarcoma of the head and neck. Cancer. 98(8):1670-80, 2003
                                    17. Chauveinc L et al: Osteosarcoma following retinoblastoma: age at onset and latency period. Ophthalmic Genet. 22(2):77-88, 2001
                                    18. Isfort RJ et al: Analysis of oncogene, tumor suppressor gene, and chromosomal alterations in HeLa x osteosarcoma somatic cell hybrids. Mol Carcinog. 25(1):30-41, 1999
                                    19. Whitehead RE et al: Telangiectatic osteosarcoma of the skull base. AJNR Am J Neuroradiol. 19(4):754-7, 1998
                                    20. Pellín A et al: Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. Diagn Mol Pathol. 6(6):333-41, 1997
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Osteosarcoma of skull base (OSa-SB)
                                              • Definitions

                                                • Neoplasm composed of malignant spindle cells producing osteoid or immature bone

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • CT Findings

                                                    • MR Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Ahrari A et al: Primary osteosarcoma of the skull base treated with endoscopic endonasal approach: a case report and literature review. J Neurol Surg Rep. 76(2):e270-4, 2015
                                                                      2. Koyama M et al: Radiation-induced osteosarcoma might mimic metastatic bone lesions: a case with bone scan and FDG PET/CT imaging. Clin Nucl Med. 40(5):427-9, 2015
                                                                      3. Hadley C et al: Osteosarcoma of the cranial vault and skull base in pediatric patients. J Neurosurg Pediatr. 13(4):380-7, 2014
                                                                      4. Mohindra S et al: Primary osteosarcoma of clivus: a short report. Br J Neurosurg. 28(4):531-3, 2014
                                                                      5. Sun TT et al: Spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia: clinical and computed tomographic features in 8 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 118(1):e24-31, 2014
                                                                      6. O'Neill JP et al: Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am. 24(1):67-78, 2013
                                                                      7. Meel R et al: Childhood osteosarcoma of greater wing of sphenoid: case report and review of literature. J Pediatr Hematol Oncol. 34(2):e59-62, 2012
                                                                      8. Ottaviani G et al: The etiology of osteosarcoma. Cancer Treat Res. 152:15-32, 2010
                                                                      9. Chennupati SK et al: Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol. 72(1):115-9, 2008
                                                                      10. Haddad H et al: [Osteosarcoma of the skull base: a case report.] Neurochirurgie. 53(6):483-5, 2007
                                                                      11. Hristov B et al: The role of radiation treatment in the contemporary management of bone tumors. J Natl Compr Canc Netw. 5(4):456-66, 2007
                                                                      12. Ghule P et al: p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. Med Sci Monit. 12(12):BR385-396, 2006
                                                                      13. Hansen MR et al: Osteosarcoma of the skull base after radiation therapy in a patient with McCune-Albright syndrome: case report. Skull Base. 13(2):79-83, 2003
                                                                      14. Matsumoto H et al: Novel germline mutation in the RB1 gene with multifocal bone tumors following retinoblastoma. Pediatr Int. 45(6):728-30, 2003
                                                                      15. Patiño-García A et al: Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. J Pediatr Hematol Oncol. 25(5):362-7, 2003
                                                                      16. Smith RB et al: National Cancer Data Base report on osteosarcoma of the head and neck. Cancer. 98(8):1670-80, 2003
                                                                      17. Chauveinc L et al: Osteosarcoma following retinoblastoma: age at onset and latency period. Ophthalmic Genet. 22(2):77-88, 2001
                                                                      18. Isfort RJ et al: Analysis of oncogene, tumor suppressor gene, and chromosomal alterations in HeLa x osteosarcoma somatic cell hybrids. Mol Carcinog. 25(1):30-41, 1999
                                                                      19. Whitehead RE et al: Telangiectatic osteosarcoma of the skull base. AJNR Am J Neuroradiol. 19(4):754-7, 1998
                                                                      20. Pellín A et al: Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. Diagn Mol Pathol. 6(6):333-41, 1997