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Small Cell Carcinoma
Sonia L. Betancourt Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Small cell lung carcinoma (SCLC)
              • Limited stage small cell lung carcinoma (LS-SCLC)
              • Extensive stage small cell lung carcinoma (ES-SCLC)
          • Synonyms

            • Oat cell lung cancer
          • Definitions

            • Primary pulmonary neuroendocrine tumor
              • More aggressive than other pulmonary neuroendocrine tumors and non-small cell lung cancers
            • Represents 13-15% of all lung cancer
          • Associated Syndromes

            • Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
              • Most common paraneoplastic syndrome associated with SCLC
              • ↑ secretion of antidiuretic hormone
                • Hyponatremia; impaired water excretion
            • Cushing syndrome
              • Increased production of adrenocorticotropic hormone
                • Weakness, hyperglycemia, polyuria, hypokalemic alkalosis
            • Eaton-Lambert syndrome
              • Impaired release of acetylcholine
                • Proximal muscle weakness
            • Encephalomyelitis
            • Limbic encephalitis 
            • Acromegaly 
              • ↑ ectopic growth hormone

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
                                              2. Lococo F et al: PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids. Tumour Biol. 35(9):8369-77, 2014
                                              3. Rekhtman N: Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med. 134(11):1628-38, 2010
                                              4. Micke P et al: Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease? Lung Cancer. 37(3):271-6, 2002
                                              5. Nicholson SA et al: Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol. 26(9):1184-97, 2002
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Small cell lung carcinoma (SCLC)
                                                          • Limited stage small cell lung carcinoma (LS-SCLC)
                                                          • Extensive stage small cell lung carcinoma (ES-SCLC)
                                                      • Synonyms

                                                        • Oat cell lung cancer
                                                      • Definitions

                                                        • Primary pulmonary neuroendocrine tumor
                                                          • More aggressive than other pulmonary neuroendocrine tumors and non-small cell lung cancers
                                                        • Represents 13-15% of all lung cancer
                                                      • Associated Syndromes

                                                        • Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
                                                          • Most common paraneoplastic syndrome associated with SCLC
                                                          • ↑ secretion of antidiuretic hormone
                                                            • Hyponatremia; impaired water excretion
                                                        • Cushing syndrome
                                                          • Increased production of adrenocorticotropic hormone
                                                            • Weakness, hyperglycemia, polyuria, hypokalemic alkalosis
                                                        • Eaton-Lambert syndrome
                                                          • Impaired release of acetylcholine
                                                            • Proximal muscle weakness
                                                        • Encephalomyelitis
                                                        • Limbic encephalitis 
                                                        • Acromegaly 
                                                          • ↑ ectopic growth hormone

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
                                                                                          2. Lococo F et al: PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids. Tumour Biol. 35(9):8369-77, 2014
                                                                                          3. Rekhtman N: Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med. 134(11):1628-38, 2010
                                                                                          4. Micke P et al: Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease? Lung Cancer. 37(3):271-6, 2002
                                                                                          5. Nicholson SA et al: Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol. 26(9):1184-97, 2002