Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Small cell lung carcinoma (SCLC)
- Limited-stage small cell lung carcinoma (LS-SCLC)
- Extensive-stage small cell lung carcinoma (ES-SCLC)
- Small cell lung carcinoma (SCLC)
Synonyms
- Oat cell lung cancer
Definitions
- Primary pulmonary neuroendocrine malignancy
- More aggressive than other pulmonary neuroendocrine tumors and non-small cell lung cancers
- Rapid tumor growth, early metastatic spread, initial responsiveness to therapy
- 13-15% of all lung cancers
- Primary pulmonary neuroendocrine malignancy
Associated Syndromes
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Most common paraneoplastic syndrome associated with SCLC
- ↑ secretion of antidiuretic hormone: Hyponatremia; impaired water excretion
- Cushing syndrome
- Increased production of adrenocorticotropic hormone: Weakness, hyperglycemia, polyuria, hypokalemic alkalosis
- Eaton-Lambert syndrome
- Impaired release of acetylcholine: Proximal muscle weakness
- Encephalomyelitis
- Limbic encephalitis
- Acromegaly : ↑ ectopic growth hormone
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Martucci F et al: Impact of 18F-FDG PET/CT in staging patients with small cell lung cancer: a systematic review and meta-analysis. Front Med (Lausanne). 6:336, 2019
- Sager O et al: Utility of molecular imaging with 2-Deoxy-2-[fluorine-18] fluoro-dglucose positron emission tomography (18F-FDG PET) for small cell lung cancer (SCLC): a radiation oncology perspective. Curr Radiopharm. 12(1):4-10, 2019
- Kalemkerian GP et al: Advances in small cell lung cancer. Hematol Oncol Clin North Am. 31(1):143-56, 2017
- Lee D et al: CT findings of small cell lung carcinoma: can recognizable features be found? Medicine (Baltimore). 95(47):e5426, 2016
- Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Small cell lung carcinoma (SCLC)
- Limited-stage small cell lung carcinoma (LS-SCLC)
- Extensive-stage small cell lung carcinoma (ES-SCLC)
- Small cell lung carcinoma (SCLC)
Synonyms
- Oat cell lung cancer
Definitions
- Primary pulmonary neuroendocrine malignancy
- More aggressive than other pulmonary neuroendocrine tumors and non-small cell lung cancers
- Rapid tumor growth, early metastatic spread, initial responsiveness to therapy
- 13-15% of all lung cancers
- Primary pulmonary neuroendocrine malignancy
Associated Syndromes
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Most common paraneoplastic syndrome associated with SCLC
- ↑ secretion of antidiuretic hormone: Hyponatremia; impaired water excretion
- Cushing syndrome
- Increased production of adrenocorticotropic hormone: Weakness, hyperglycemia, polyuria, hypokalemic alkalosis
- Eaton-Lambert syndrome
- Impaired release of acetylcholine: Proximal muscle weakness
- Encephalomyelitis
- Limbic encephalitis
- Acromegaly : ↑ ectopic growth hormone
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Martucci F et al: Impact of 18F-FDG PET/CT in staging patients with small cell lung cancer: a systematic review and meta-analysis. Front Med (Lausanne). 6:336, 2019
- Sager O et al: Utility of molecular imaging with 2-Deoxy-2-[fluorine-18] fluoro-dglucose positron emission tomography (18F-FDG PET) for small cell lung cancer (SCLC): a radiation oncology perspective. Curr Radiopharm. 12(1):4-10, 2019
- Kalemkerian GP et al: Advances in small cell lung cancer. Hematol Oncol Clin North Am. 31(1):143-56, 2017
- Lee D et al: CT findings of small cell lung carcinoma: can recognizable features be found? Medicine (Baltimore). 95(47):e5426, 2016
- Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
