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Small Cell Lung Cancer
Bhavana Budigi, MD; Anita Thomas, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Small cell lung cancer (SCLC)
              • Neuroendocrine tumor that originates from epithelial cells
              • Aggressive
              • Early metastases common
              • ~ 15% of all lung cancers

          IMAGING

          • General Features

            • Imaging Recommendations

              DIFFERENTIAL DIAGNOSIS

                PATHOLOGY

                • Staging, Grading, & Classification

                  • Microscopic Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Image Interpretation Pearls

                              • Reporting Tips

                                Selected References

                                1. Krarup MMK et al: Heterogeneity in tumours: Validating the use of radiomic features on 18F-FDG PET/CT scans of lung cancer patients as a prognostic tool. Radiother Oncol. 144:72-8, 2019
                                2. Carter BW et al: Revisions to the TNM staging of lung cancer: rationale, significance, and clinical application. Radiographics. 38(2):374-91, 2018
                                3. Greenspan BS: Role of PET/CT for precision medicine in lung cancer: perspective of the Society of Nuclear Medicine and Molecular Imaging. Transl Lung Cancer Res. 6(6):617-20, 2017
                                4. Jiang R et al: Combining PET/CT with serum tumor markers to improve the evaluation of histological type of suspicious lung cancers. PLoS One. 12(9):e0184338, 2017
                                5. Mitchell MD et al: Imaging for the pretreatment staging of small cell lung cancer: A systematic review. Acad Radiol. 23(8):1047-56, 2016
                                6. Hochhegger B et al: PET/CT imaging in lung cancer: indications and findings. J Bras Pneumol. 41(3):264-74, 2015
                                7. Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
                                8. Pillai RN et al: Small cell lung cancer: therapies and targets. Semin Oncol. 41(1):133-42, 2014
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Definitions

                                          • Small cell lung cancer (SCLC)
                                            • Neuroendocrine tumor that originates from epithelial cells
                                            • Aggressive
                                            • Early metastases common
                                            • ~ 15% of all lung cancers

                                        IMAGING

                                        • General Features

                                          • Imaging Recommendations

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • Staging, Grading, & Classification

                                                • Microscopic Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          DIAGNOSTIC CHECKLIST

                                                          • Image Interpretation Pearls

                                                            • Reporting Tips

                                                              Selected References

                                                              1. Krarup MMK et al: Heterogeneity in tumours: Validating the use of radiomic features on 18F-FDG PET/CT scans of lung cancer patients as a prognostic tool. Radiother Oncol. 144:72-8, 2019
                                                              2. Carter BW et al: Revisions to the TNM staging of lung cancer: rationale, significance, and clinical application. Radiographics. 38(2):374-91, 2018
                                                              3. Greenspan BS: Role of PET/CT for precision medicine in lung cancer: perspective of the Society of Nuclear Medicine and Molecular Imaging. Transl Lung Cancer Res. 6(6):617-20, 2017
                                                              4. Jiang R et al: Combining PET/CT with serum tumor markers to improve the evaluation of histological type of suspicious lung cancers. PLoS One. 12(9):e0184338, 2017
                                                              5. Mitchell MD et al: Imaging for the pretreatment staging of small cell lung cancer: A systematic review. Acad Radiol. 23(8):1047-56, 2016
                                                              6. Hochhegger B et al: PET/CT imaging in lung cancer: indications and findings. J Bras Pneumol. 41(3):264-74, 2015
                                                              7. Carter BW et al: Small cell lung carcinoma: staging, imaging, and treatment considerations. Radiographics. 34(6):1707-21, 2014
                                                              8. Pillai RN et al: Small cell lung cancer: therapies and targets. Semin Oncol. 41(1):133-42, 2014