Mucosal squamous cell carcinoma (SCCa) arising from soft palate (SP) and uvula (tip of SP)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rapado-González Ó et al: Association of salivary human papillomavirus infection and oral and oropharyngeal cancer: a meta-analysis. J Clin Med. 9(5), 2020
Zheng Y et al: Differentiation between benign and malignant palatal tumors using conventional MRI: a retrospective analysis of 130 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 125(4):343-50, 2018
Glastonbury CM et al: Setting the stage for 2018: how the changes in the American Joint Committee on Cancer/Union for International Cancer Control Cancer Staging Manual Eighth Edition impact radiologists. AJNR Am J Neuroradiol. 38(12):2231-7, 2017
Lydiatt WM et al: Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(2):122-37, 2017
Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
Overton LJ et al: Squamous cell carcinoma of the uvula: an analysis of factors affecting survival. Laryngoscope. 123(4):898-903, 2013
Iyer NG et al: Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome. Head Neck. 34(8):1071-80, 2012
Joo YH et al: Factors influencing the outcomes of primary surgery with postoperative radiotherapy for pN2 oropharyneal squamous cell carcinoma. Oral Oncol. 48(1):90-4, 2012
Olzowy B et al: Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: a retrospective analysis of 352 cases after bilateral neck dissection. Head Neck. 33(2):239-43, 2011
Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
Been MJ et al: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 118(8):1377-82, 2008
Chera BS et al: Definitive radiation therapy for squamous cell carcinoma of the soft palate. Head Neck. 30(8):1114-9, 2008
Karatzanis AD et al: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx. 35(4):592-6, 2008
Hobbs CG et al: Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. 31(4):259-66, 2006
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KEY FACTS
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TERMINOLOGY
Definitions
Mucosal squamous cell carcinoma (SCCa) arising from soft palate (SP) and uvula (tip of SP)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rapado-González Ó et al: Association of salivary human papillomavirus infection and oral and oropharyngeal cancer: a meta-analysis. J Clin Med. 9(5), 2020
Zheng Y et al: Differentiation between benign and malignant palatal tumors using conventional MRI: a retrospective analysis of 130 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 125(4):343-50, 2018
Glastonbury CM et al: Setting the stage for 2018: how the changes in the American Joint Committee on Cancer/Union for International Cancer Control Cancer Staging Manual Eighth Edition impact radiologists. AJNR Am J Neuroradiol. 38(12):2231-7, 2017
Lydiatt WM et al: Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(2):122-37, 2017
Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
Overton LJ et al: Squamous cell carcinoma of the uvula: an analysis of factors affecting survival. Laryngoscope. 123(4):898-903, 2013
Iyer NG et al: Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome. Head Neck. 34(8):1071-80, 2012
Joo YH et al: Factors influencing the outcomes of primary surgery with postoperative radiotherapy for pN2 oropharyneal squamous cell carcinoma. Oral Oncol. 48(1):90-4, 2012
Olzowy B et al: Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: a retrospective analysis of 352 cases after bilateral neck dissection. Head Neck. 33(2):239-43, 2011
Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
Been MJ et al: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 118(8):1377-82, 2008
Chera BS et al: Definitive radiation therapy for squamous cell carcinoma of the soft palate. Head Neck. 30(8):1114-9, 2008
Karatzanis AD et al: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx. 35(4):592-6, 2008
Hobbs CG et al: Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. 31(4):259-66, 2006
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