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Soft Palate Squamous Cell Carcinoma
Luke N. Ledbetter, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Mucosal squamous cell carcinoma (SCCa) arising from soft palate (SP) and uvula (tip of SP)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
                                          2. Overton LJ et al: Squamous cell carcinoma of the uvula: an analysis of factors affecting survival. Laryngoscope. 123(4):898-903, 2013
                                          3. Iyer NG et al: Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome. Head Neck. 34(8):1071-80, 2012
                                          4. Joo YH et al: Factors influencing the outcomes of primary surgery with postoperative radiotherapy for pN2 oropharyneal squamous cell carcinoma. Oral Oncol. 48(1):90-4, 2012
                                          5. Olzowy B et al: Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: a retrospective analysis of 352 cases after bilateral neck dissection. Head Neck. 33(2):239-43, 2011
                                          6. Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
                                          7. Been MJ et al: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 118(8):1377-82, 2008
                                          8. Chera BS et al: Definitive radiation therapy for squamous cell carcinoma of the soft palate. Head Neck. 30(8):1114-9, 2008
                                          9. Karatzanis AD et al: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx. 35(4):592-6, 2008
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Mucosal squamous cell carcinoma (SCCa) arising from soft palate (SP) and uvula (tip of SP)

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • Staging, Grading, & Classification

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
                                                                                  2. Overton LJ et al: Squamous cell carcinoma of the uvula: an analysis of factors affecting survival. Laryngoscope. 123(4):898-903, 2013
                                                                                  3. Iyer NG et al: Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome. Head Neck. 34(8):1071-80, 2012
                                                                                  4. Joo YH et al: Factors influencing the outcomes of primary surgery with postoperative radiotherapy for pN2 oropharyneal squamous cell carcinoma. Oral Oncol. 48(1):90-4, 2012
                                                                                  5. Olzowy B et al: Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: a retrospective analysis of 352 cases after bilateral neck dissection. Head Neck. 33(2):239-43, 2011
                                                                                  6. Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
                                                                                  7. Been MJ et al: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 118(8):1377-82, 2008
                                                                                  8. Chera BS et al: Definitive radiation therapy for squamous cell carcinoma of the soft palate. Head Neck. 30(8):1114-9, 2008
                                                                                  9. Karatzanis AD et al: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx. 35(4):592-6, 2008