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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Solitary fibrous tumor (SFT)
- Hemangiopericytoma (HPC)
Definitions
- Mesenchymal neoplasm composed of oval to spindle-shaped cells with prominent branching (HPC-like) vascular pattern
- Bone
- Most previously diagnosed HPCs of bone are now classified as SFTs
- CNS
- SFT/HPC terminology still utilized
- Considered to exist in spectrum
- Tumors previously considered SFTs represent lower end of spectrum with more indolent behavior
- Tumors previously considered HPCs in CNS represent higher end of spectrum with less favorable prognosis
- Most SFTs/HPCs harbor NAB2/STAT6 fusion
- Considered to exist in spectrum
- SFT/HPC terminology still utilized
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- González-Vargas PM et al: Hemangiopericytoma/solitary fibrous tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: a 10-year analysis of a heterogeneous series in a single tertiary center. Neurocirugia (Astur). 31(1):14-23, 2020
- Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
- Li Z et al: Primary epidural hemangiopericytoma of the thoracic spine: case report and literature review. J Clin Neurosci. 60:142-7, 2019
- Chen H et al: Solitary fibrous tumor of the central nervous system: a clinicopathologic study of 24 cases. Acta Neurochir (Wien). 154(2):237-48, 2012
- Verbeke SL et al: A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone. Am J Surg Pathol. 34(6):777-83, 2010
- Fitzpatrick D et al: Intradural hemangiopericytoma of the lumbar spine: a rare entity. AJNR Am J Neuroradiol. 30(1):152-4, 2009
- Park MS et al: New insights into the hemangiopericytoma/solitary fibrous tumor spectrum of tumors. Curr Opin Oncol. 21(4):327-31, 2009
- Kashiwazaki D et al: Subpial hemangiopericytoma with marked extramedullary growth: case report. Neurosurgery. 61(6):E1336-7; discussion E1337, 2007
- Gengler C et al: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 48(1):63-74, 2006
- Cox DP et al: Myopericytoma of the thoracic spine: a case report. Spine. 28(2):E30-2, 2003
- Musacchio M et al: Posterior cervical haemangiopericytoma with intracranial and skull base extension. Diagnostic and therapeutic challenge of a rare hypervascular neoplasm. J Neuroradiol. 30(3):180-7, 2003
- Woitzik J et al: Delayed manifestation of spinal metastasis: a special feature of hemangiopericytoma. Clin Neurol Neurosurg. 105(3):159-66, 2003
- Akhaddar A et al: Thoracic epidural hemangiopericytoma. Case report. J Neurosurg Sci. 46(2):89-92; discussion 92, 2002
- Betchen S et al: Intradural hemangiopericytoma of the lumbar spine: case report. Neurosurgery. 50(3):654-7, 2002
- Ijiri K et al: Primary epidural hemangiopericytoma in the lumbar spine: a case report. Spine (Phila Pa 1976). 27(7):E189-92, 2002
- Tayoro K et al: [Imaging of meningeal hemangiopericytomas] J Radiol. 83(4 Pt 1):459-65, 2002
- Suzuki SO et al: Clinicopathological features of solitary fibrous tumor of the meninges: An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. Pathol Int. 50(10):808-17, 2000
- Nonaka M et al: Metastatic meningeal hemangiopericytoma of thoracic spine. Clin Neurol Neurosurg. 100(3):228-30, 1998
- Lin YJ et al: Primary hemangiopericytoma in the axis bone: case report and review of literature. Neurosurgery. 39(2):397-9; discussion 399-400, 1996
- Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
- Kozlowski K et al: Primary sacral bone tumours in children (report of 16 cases with a short literature review). Australas Radiol. 34(2):142-9, 1990
- Bridges LR et al: Haemangiopericytic meningioma of the sacral canal: a case report. J Neurol Neurosurg Psychiatry. 51(2):288-90, 1988
- Cuccurullo L et al: Hemangiopericytoma of the cervical spine. A case report. Acta Neurol (Napoli). 6(6):472-81, 1984
- Beadle GF et al: Treatment of advanced malignant hemangiopericytoma with combination adriamycin and DTIC: a report of four cases. J Surg Oncol. 22(3):167-70, 1983
- Muraszko KM et al: Hemangiopericytomas of the spine. Neurosurgery. 10(4):473-9, 1982
- Cappabianca P et al: Hemangiopericytoma of the spinal canal. Surg Neurol. 15(4):298-302, 1981
- Anderson C et al: Skeletal metastases of an intracranial malignant hemangiopericytoma. Report of a case. J Bone Joint Surg Am. 62(1):145-8, 1980
- Stern MB et al: Hemangiopericytoma of the cervical spine: report of an unusual case. Clin Orthop. (151):201-4, 1980
- Subbarao K et al: Primary malignant neoplasms. Semin Roentgenol. 14(1):44-57, 1979
- Harris DJ et al: Hemangiopericytoma of the spinal canal. Report of three cases. J Neurosurg. 49(6):914-20, 1978
- Hart S et al: Haemangiopericytoma of the pre-sacral space. Br J Surg. 60(7):583-4, 1973
- Baxter PJ et al: Haemangiopericytoma. Light and electron microscopy studies of a cerebral secondary tumour. Acta Neuropathol (Berl). 21(3):253-7, 1972
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Solitary fibrous tumor (SFT)
- Hemangiopericytoma (HPC)
Definitions
- Mesenchymal neoplasm composed of oval to spindle-shaped cells with prominent branching (HPC-like) vascular pattern
- Bone
- Most previously diagnosed HPCs of bone are now classified as SFTs
- CNS
- SFT/HPC terminology still utilized
- Considered to exist in spectrum
- Tumors previously considered SFTs represent lower end of spectrum with more indolent behavior
- Tumors previously considered HPCs in CNS represent higher end of spectrum with less favorable prognosis
- Most SFTs/HPCs harbor NAB2/STAT6 fusion
- Considered to exist in spectrum
- SFT/HPC terminology still utilized
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- González-Vargas PM et al: Hemangiopericytoma/solitary fibrous tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: a 10-year analysis of a heterogeneous series in a single tertiary center. Neurocirugia (Astur). 31(1):14-23, 2020
- Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
- Li Z et al: Primary epidural hemangiopericytoma of the thoracic spine: case report and literature review. J Clin Neurosci. 60:142-7, 2019
- Chen H et al: Solitary fibrous tumor of the central nervous system: a clinicopathologic study of 24 cases. Acta Neurochir (Wien). 154(2):237-48, 2012
- Verbeke SL et al: A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone. Am J Surg Pathol. 34(6):777-83, 2010
- Fitzpatrick D et al: Intradural hemangiopericytoma of the lumbar spine: a rare entity. AJNR Am J Neuroradiol. 30(1):152-4, 2009
- Park MS et al: New insights into the hemangiopericytoma/solitary fibrous tumor spectrum of tumors. Curr Opin Oncol. 21(4):327-31, 2009
- Kashiwazaki D et al: Subpial hemangiopericytoma with marked extramedullary growth: case report. Neurosurgery. 61(6):E1336-7; discussion E1337, 2007
- Gengler C et al: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 48(1):63-74, 2006
- Cox DP et al: Myopericytoma of the thoracic spine: a case report. Spine. 28(2):E30-2, 2003
- Musacchio M et al: Posterior cervical haemangiopericytoma with intracranial and skull base extension. Diagnostic and therapeutic challenge of a rare hypervascular neoplasm. J Neuroradiol. 30(3):180-7, 2003
- Woitzik J et al: Delayed manifestation of spinal metastasis: a special feature of hemangiopericytoma. Clin Neurol Neurosurg. 105(3):159-66, 2003
- Akhaddar A et al: Thoracic epidural hemangiopericytoma. Case report. J Neurosurg Sci. 46(2):89-92; discussion 92, 2002
- Betchen S et al: Intradural hemangiopericytoma of the lumbar spine: case report. Neurosurgery. 50(3):654-7, 2002
- Ijiri K et al: Primary epidural hemangiopericytoma in the lumbar spine: a case report. Spine (Phila Pa 1976). 27(7):E189-92, 2002
- Tayoro K et al: [Imaging of meningeal hemangiopericytomas] J Radiol. 83(4 Pt 1):459-65, 2002
- Suzuki SO et al: Clinicopathological features of solitary fibrous tumor of the meninges: An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. Pathol Int. 50(10):808-17, 2000
- Nonaka M et al: Metastatic meningeal hemangiopericytoma of thoracic spine. Clin Neurol Neurosurg. 100(3):228-30, 1998
- Lin YJ et al: Primary hemangiopericytoma in the axis bone: case report and review of literature. Neurosurgery. 39(2):397-9; discussion 399-400, 1996
- Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
- Kozlowski K et al: Primary sacral bone tumours in children (report of 16 cases with a short literature review). Australas Radiol. 34(2):142-9, 1990
- Bridges LR et al: Haemangiopericytic meningioma of the sacral canal: a case report. J Neurol Neurosurg Psychiatry. 51(2):288-90, 1988
- Cuccurullo L et al: Hemangiopericytoma of the cervical spine. A case report. Acta Neurol (Napoli). 6(6):472-81, 1984
- Beadle GF et al: Treatment of advanced malignant hemangiopericytoma with combination adriamycin and DTIC: a report of four cases. J Surg Oncol. 22(3):167-70, 1983
- Muraszko KM et al: Hemangiopericytomas of the spine. Neurosurgery. 10(4):473-9, 1982
- Cappabianca P et al: Hemangiopericytoma of the spinal canal. Surg Neurol. 15(4):298-302, 1981
- Anderson C et al: Skeletal metastases of an intracranial malignant hemangiopericytoma. Report of a case. J Bone Joint Surg Am. 62(1):145-8, 1980
- Stern MB et al: Hemangiopericytoma of the cervical spine: report of an unusual case. Clin Orthop. (151):201-4, 1980
- Subbarao K et al: Primary malignant neoplasms. Semin Roentgenol. 14(1):44-57, 1979
- Harris DJ et al: Hemangiopericytoma of the spinal canal. Report of three cases. J Neurosurg. 49(6):914-20, 1978
- Hart S et al: Haemangiopericytoma of the pre-sacral space. Br J Surg. 60(7):583-4, 1973
- Baxter PJ et al: Haemangiopericytoma. Light and electron microscopy studies of a cerebral secondary tumour. Acta Neuropathol (Berl). 21(3):253-7, 1972
