Primary intramedullary neoplasm of spinal cord originating from astrocytes
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Perwein T et al: High frequency of disease progression in pediatric spinal cord low-grade glioma (LGG): management strategies and results from the German LGG study group. Neuro Oncol. 23(7):1148-62, 2021
Carey SS et al: Evaluating pediatric spinal low-grade gliomas: a 30-year retrospective analysis. J Neurooncol. 145(3):519-29, 2019
Ogunlade J et al: Primary spinal astrocytomas: a literature review. Cureus. 11(7):e5247, 2019
She DJ et al: MR imaging features of spinal pilocytic astrocytoma. BMC Med Imaging. 19(1):5, 2019
Aboian MS et al: Imaging characteristics of pediatric diffuse midline gliomas with histone H3 K27M mutation. AJNR Am J Neuroradiol. 38(4):795-800, 2017
Karikari IO et al: Impact of tumor histology on resectability and neurological outcome in primary intramedullary spinal cord tumors: a single-center experience with 102 patients. Neurosurgery. 76 Suppl 1:S4-13; discussion S13, 2015
Ahmed R et al: Long-term disease and neurological outcomes in patients with pediatric intramedullary spinal cord tumors. J Neurosurg Pediatr. 13(6):600-12, 2014
Milano MT et al: Primary spinal cord glioma: a surveillance, epidemiology, and end results database study. J Neurooncol. 98(1):83-92, 2010
Raco A et al: High-grade intramedullary astrocytomas: 30 years' experience at the Neurosurgery Department of the University of Rome "Sapienza". J Neurosurg Spine. 12(2):144-53, 2010
Seo HS et al: Nonenhancing intramedullary astrocytomas and other MR imaging features: a retrospective study and systematic review. AJNR Am J Neuroradiol. 31(3):498-503, 2010
Tendulkar RD et al: Irradiation of pediatric high-grade spinal cord tumors. Int J Radiat Oncol Biol Phys. 78(5):1451-6, 2010
Garcés-Ambrossi GL et al: Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases. J Neurosurg Spine. 11(5):591-9, 2009
Peraud A et al: Recurrent spinal cord astrocytoma with intraventricular seeding. Childs Nerv Syst. 20(2):114-8, 2004
Colby C et al: Rapid deterioration of a newborn with congenital spinal cord astrocytoma. Med Pediatr Oncol. 36(4):500-2, 2001
Chacko AG et al: Favorable outcome after radical excision of a 'holocord' astrocytoma. Clin Neurol Neurosurg. 102(4):240-2, 2000
Constantini S et al: Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg. 93(2 Suppl):183-93, 2000
Houten JK et al: Pediatric intramedullary spinal cord tumors: special considerations. J Neurooncol. 47(3):225-30, 2000
Merchant TE et al: Pediatric low-grade and ependymal spinal cord tumors. Pediatr Neurosurg. 32(1):30-6, 2000
Ng A et al: Congenital spinal astrocytoma: how favourable is the long-term outcome? Br J Neurosurg. 14(4):366-70, 2000
Nishio S et al: Spinal cord gliomas: management and outcome with reference to adjuvant therapy. J Clin Neurosci. 7(1):20-3, 2000
Wilmshurst JM et al: Positron emission tomography in imaging spinal cord tumors. J Child Neurol. 15(7):465-72, 2000
Abdel-Wahab M et al: Prognostic factors and survival in patients with spinal cord gliomas after radiation therapy. Am J Clin Oncol. 22(4):344-51, 1999
Kulkarni AV et al: MR characteristics of malignant spinal cord astrocytomas in children. Can J Neurol Sci. 26(4):290-3, 1999
Bouffet E et al: Prognostic factors in pediatric spinal cord astrocytoma. Cancer. 83(11):2391-9, 1998
Lowis SP et al: Chemotherapy for spinal cord astrocytoma: can natural history be modified? Childs Nerv Syst. 14(7):317-21, 1998
Yagi T et al: Intramedullary spinal cord tumour associated with neurofibromatosis type 1. Acta Neurochir (Wien). 139(11):1055-60, 1997
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Spinal glioma, intramedullary glioma
Definitions
Primary intramedullary neoplasm of spinal cord originating from astrocytes
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Perwein T et al: High frequency of disease progression in pediatric spinal cord low-grade glioma (LGG): management strategies and results from the German LGG study group. Neuro Oncol. 23(7):1148-62, 2021
Carey SS et al: Evaluating pediatric spinal low-grade gliomas: a 30-year retrospective analysis. J Neurooncol. 145(3):519-29, 2019
Ogunlade J et al: Primary spinal astrocytomas: a literature review. Cureus. 11(7):e5247, 2019
She DJ et al: MR imaging features of spinal pilocytic astrocytoma. BMC Med Imaging. 19(1):5, 2019
Aboian MS et al: Imaging characteristics of pediatric diffuse midline gliomas with histone H3 K27M mutation. AJNR Am J Neuroradiol. 38(4):795-800, 2017
Karikari IO et al: Impact of tumor histology on resectability and neurological outcome in primary intramedullary spinal cord tumors: a single-center experience with 102 patients. Neurosurgery. 76 Suppl 1:S4-13; discussion S13, 2015
Ahmed R et al: Long-term disease and neurological outcomes in patients with pediatric intramedullary spinal cord tumors. J Neurosurg Pediatr. 13(6):600-12, 2014
Milano MT et al: Primary spinal cord glioma: a surveillance, epidemiology, and end results database study. J Neurooncol. 98(1):83-92, 2010
Raco A et al: High-grade intramedullary astrocytomas: 30 years' experience at the Neurosurgery Department of the University of Rome "Sapienza". J Neurosurg Spine. 12(2):144-53, 2010
Seo HS et al: Nonenhancing intramedullary astrocytomas and other MR imaging features: a retrospective study and systematic review. AJNR Am J Neuroradiol. 31(3):498-503, 2010
Tendulkar RD et al: Irradiation of pediatric high-grade spinal cord tumors. Int J Radiat Oncol Biol Phys. 78(5):1451-6, 2010
Garcés-Ambrossi GL et al: Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases. J Neurosurg Spine. 11(5):591-9, 2009
Peraud A et al: Recurrent spinal cord astrocytoma with intraventricular seeding. Childs Nerv Syst. 20(2):114-8, 2004
Colby C et al: Rapid deterioration of a newborn with congenital spinal cord astrocytoma. Med Pediatr Oncol. 36(4):500-2, 2001
Chacko AG et al: Favorable outcome after radical excision of a 'holocord' astrocytoma. Clin Neurol Neurosurg. 102(4):240-2, 2000
Constantini S et al: Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg. 93(2 Suppl):183-93, 2000
Houten JK et al: Pediatric intramedullary spinal cord tumors: special considerations. J Neurooncol. 47(3):225-30, 2000
Merchant TE et al: Pediatric low-grade and ependymal spinal cord tumors. Pediatr Neurosurg. 32(1):30-6, 2000
Ng A et al: Congenital spinal astrocytoma: how favourable is the long-term outcome? Br J Neurosurg. 14(4):366-70, 2000
Nishio S et al: Spinal cord gliomas: management and outcome with reference to adjuvant therapy. J Clin Neurosci. 7(1):20-3, 2000
Wilmshurst JM et al: Positron emission tomography in imaging spinal cord tumors. J Child Neurol. 15(7):465-72, 2000
Abdel-Wahab M et al: Prognostic factors and survival in patients with spinal cord gliomas after radiation therapy. Am J Clin Oncol. 22(4):344-51, 1999
Kulkarni AV et al: MR characteristics of malignant spinal cord astrocytomas in children. Can J Neurol Sci. 26(4):290-3, 1999
Bouffet E et al: Prognostic factors in pediatric spinal cord astrocytoma. Cancer. 83(11):2391-9, 1998
Lowis SP et al: Chemotherapy for spinal cord astrocytoma: can natural history be modified? Childs Nerv Syst. 14(7):317-21, 1998
Yagi T et al: Intramedullary spinal cord tumour associated with neurofibromatosis type 1. Acta Neurochir (Wien). 139(11):1055-60, 1997
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