Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Intramedullary spinal cord metastatic (ISCM) disease
Definitions
- Metastatic lesion from primary carcinoma in another organ (including brain)
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Barrie U et al: Intramedullary spinal metastatic renal cell carcinoma: systematic review of disease presentation, treatment, and prognosis with case illustration. World Neurosurg. 134:584-93, 2020
- Goyal A et al: Intramedullary spinal cord metastases: an institutional review of survival and outcomes. J Neurooncol. 142(2):347-54, 2019
- Payer S et al: Intramedullary spinal cord metastases: an increasingly common diagnosis. Neurosurg Focus. 39(2):E15, 2015
- Rykken JB et al: Rim and flame signs: postgadolinium MRI findings specific for non-CNS intramedullary spinal cord metastases. AJNR Am J Neuroradiol. 34(4):908-15, 2013
- Sung WS et al: Intramedullary spinal cord metastases: a 20-year institutional experience with a comprehensive literature review. World Neurosurg. 79(3-4):576-84, 2013
- Birbilis TA et al: Spinal metastasis of glioblastoma multiforme: an uncommon suspect? Spine (Phila Pa 1976). 35(7):E264-9, 2010
- Graber JJ et al: Myelopathies in patients with cancer. Arch Neurol. 67(3):298-304, 2010
- Dam-Hieu P et al: Retrospective study of 19 patients with intramedullary spinal cord metastasis. Clin Neurol Neurosurg. 111(1):10-7, 2009
- Ebner FH et al: Intramedullary lesions of the conus medullaris: differential diagnosis and surgical management. Neurosurg Rev. 32(3):287-300; discussion 300-1, 2009
- Pellegrini D et al: Intramedullary spinal cord metastasis. Arch Neurol. 66(11):1422, 2009
- Shin DA et al: Stereotactic spine radiosurgery for intradural and intramedullary metastasis. Neurosurg Focus. 27(6):E10, 2009
- Donovan DJ et al: Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine (Phila Pa 1976). 31(14):E460-3, 2006
- Aryan HE et al: Intramedullary spinal cord metastasis of lung adenocarcinoma presenting as Brown-Sequard syndrome. Surg Neurol. 61(1):72-6, 2004
- Kaya RA et al: Intramedullary spinal cord metastasis: a rare and devastating complication of cancer--two case reports. Neurol Med Chir (Tokyo). 43(12):612-5, 2003
- Reddy P et al: Intramedullary spinal cord metastases: case report and review of literature. J La State Med Soc. 155(1):44-5, 2003
- Ogino M et al: Successful removal of solitary intramedullary spinal cord metastasis from colon cancer. Clin Neurol Neurosurg. 104(2):152-6, 2002
- Fakih M et al: Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases. Ann Oncol. 12(8):1173-7, 2001
- Mortimer N et al: Intramedullary spinal cord metastasis. Lancet Oncol. 2(10):607, 2001
- Potti A et al: Intramedullary spinal cord metastases (ISCM) and non-small cell lung carcinoma (NSCLC): clinical patterns, diagnosis and therapeutic considerations. Lung Cancer. 31(2-3):319-23, 2001
- Ateaque A et al: Intramedullary spinal cord metastases from a hypernephroma 11 years following the diagnosis and treatment of the primary lesion. Br J Neurosurg. 14(5):474-6, 2000
- Mathur S et al: Late intramedullary spinal cord metastasis in a patient with lymphoblastic lymphoma: case report. J Clin Neurosci. 7(3):264-8, 2000
- Schijns OE et al: Intramedullary spinal cord metastasis as a first manifestation of a renal cell carcinoma: report of a case and review of the literature. Clin Neurol Neurosurg. 102(4):249-54, 2000
- Sutter B et al: Treatment options and time course for intramedullary spinal cord metastasis. Report of three cases and review of the literature. Neurosurg Focus. 4(5):e3, 1998
- Keung YK et al: Secondary syringomyelia due to intramedullary spinal cord metastasis. Case report and review of literature. Am J Clin Oncol. 20(6):577-9, 1997
- Connolly ES Jr et al: Intramedullary spinal cord metastasis: report of three cases and review of the literature. Surg Neurol. 46(4):329-37; discussion 337-8, 1996
- Honma Y et al: Intramedullary spinal cord and brain metastases from thyroid carcinoma detected 11 years after initial diagnosis--case report. Neurol Med Chir (Tokyo). 36(8):593-7, 1996
- Phuphanich S et al: Magnetic resonance imaging of syrinx associated with intramedullary metastases and leptomeningeal disease. J Neuroimaging. 6(2):115-7, 1996
- Schiff D et al: Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology. 47(4):906-12, 1996
- Shibamoto Y et al: Spinal metastasis from occult intracranial germinoma mimicking primary intramedullary tumour. Neuroradiology. 36(2):137-8, 1994
- Raco A et al: Intramedullary metastasis of unknown origin: a case report. Neurosurg Rev. 15(2):135-8, 1992
- Tognetti F et al: Metastases of the spinal cord from remote neoplasms. Study of five cases. Surg Neurol. 30(3):220-7, 1988
- Van Velthoven V et al: Intramedullary spread of a cerebral oligodendroglioma. Surg Neurol. 30(6):476-81, 1988
- Foster O et al: Syrinx associated with intramedullary metastasis. J Neurol Neurosurg Psychiatry. 50(8):1067-70, 1987
- Winkelman MD et al: Intramedullary spinal cord metastasis. Diagnostic and therapeutic considerations. Arch Neurol. 44(5):526-31, 1987
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Intramedullary spinal cord metastatic (ISCM) disease
Definitions
- Metastatic lesion from primary carcinoma in another organ (including brain)
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Barrie U et al: Intramedullary spinal metastatic renal cell carcinoma: systematic review of disease presentation, treatment, and prognosis with case illustration. World Neurosurg. 134:584-93, 2020
- Goyal A et al: Intramedullary spinal cord metastases: an institutional review of survival and outcomes. J Neurooncol. 142(2):347-54, 2019
- Payer S et al: Intramedullary spinal cord metastases: an increasingly common diagnosis. Neurosurg Focus. 39(2):E15, 2015
- Rykken JB et al: Rim and flame signs: postgadolinium MRI findings specific for non-CNS intramedullary spinal cord metastases. AJNR Am J Neuroradiol. 34(4):908-15, 2013
- Sung WS et al: Intramedullary spinal cord metastases: a 20-year institutional experience with a comprehensive literature review. World Neurosurg. 79(3-4):576-84, 2013
- Birbilis TA et al: Spinal metastasis of glioblastoma multiforme: an uncommon suspect? Spine (Phila Pa 1976). 35(7):E264-9, 2010
- Graber JJ et al: Myelopathies in patients with cancer. Arch Neurol. 67(3):298-304, 2010
- Dam-Hieu P et al: Retrospective study of 19 patients with intramedullary spinal cord metastasis. Clin Neurol Neurosurg. 111(1):10-7, 2009
- Ebner FH et al: Intramedullary lesions of the conus medullaris: differential diagnosis and surgical management. Neurosurg Rev. 32(3):287-300; discussion 300-1, 2009
- Pellegrini D et al: Intramedullary spinal cord metastasis. Arch Neurol. 66(11):1422, 2009
- Shin DA et al: Stereotactic spine radiosurgery for intradural and intramedullary metastasis. Neurosurg Focus. 27(6):E10, 2009
- Donovan DJ et al: Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine (Phila Pa 1976). 31(14):E460-3, 2006
- Aryan HE et al: Intramedullary spinal cord metastasis of lung adenocarcinoma presenting as Brown-Sequard syndrome. Surg Neurol. 61(1):72-6, 2004
- Kaya RA et al: Intramedullary spinal cord metastasis: a rare and devastating complication of cancer--two case reports. Neurol Med Chir (Tokyo). 43(12):612-5, 2003
- Reddy P et al: Intramedullary spinal cord metastases: case report and review of literature. J La State Med Soc. 155(1):44-5, 2003
- Ogino M et al: Successful removal of solitary intramedullary spinal cord metastasis from colon cancer. Clin Neurol Neurosurg. 104(2):152-6, 2002
- Fakih M et al: Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases. Ann Oncol. 12(8):1173-7, 2001
- Mortimer N et al: Intramedullary spinal cord metastasis. Lancet Oncol. 2(10):607, 2001
- Potti A et al: Intramedullary spinal cord metastases (ISCM) and non-small cell lung carcinoma (NSCLC): clinical patterns, diagnosis and therapeutic considerations. Lung Cancer. 31(2-3):319-23, 2001
- Ateaque A et al: Intramedullary spinal cord metastases from a hypernephroma 11 years following the diagnosis and treatment of the primary lesion. Br J Neurosurg. 14(5):474-6, 2000
- Mathur S et al: Late intramedullary spinal cord metastasis in a patient with lymphoblastic lymphoma: case report. J Clin Neurosci. 7(3):264-8, 2000
- Schijns OE et al: Intramedullary spinal cord metastasis as a first manifestation of a renal cell carcinoma: report of a case and review of the literature. Clin Neurol Neurosurg. 102(4):249-54, 2000
- Sutter B et al: Treatment options and time course for intramedullary spinal cord metastasis. Report of three cases and review of the literature. Neurosurg Focus. 4(5):e3, 1998
- Keung YK et al: Secondary syringomyelia due to intramedullary spinal cord metastasis. Case report and review of literature. Am J Clin Oncol. 20(6):577-9, 1997
- Connolly ES Jr et al: Intramedullary spinal cord metastasis: report of three cases and review of the literature. Surg Neurol. 46(4):329-37; discussion 337-8, 1996
- Honma Y et al: Intramedullary spinal cord and brain metastases from thyroid carcinoma detected 11 years after initial diagnosis--case report. Neurol Med Chir (Tokyo). 36(8):593-7, 1996
- Phuphanich S et al: Magnetic resonance imaging of syrinx associated with intramedullary metastases and leptomeningeal disease. J Neuroimaging. 6(2):115-7, 1996
- Schiff D et al: Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology. 47(4):906-12, 1996
- Shibamoto Y et al: Spinal metastasis from occult intracranial germinoma mimicking primary intramedullary tumour. Neuroradiology. 36(2):137-8, 1994
- Raco A et al: Intramedullary metastasis of unknown origin: a case report. Neurosurg Rev. 15(2):135-8, 1992
- Tognetti F et al: Metastases of the spinal cord from remote neoplasms. Study of five cases. Surg Neurol. 30(3):220-7, 1988
- Van Velthoven V et al: Intramedullary spread of a cerebral oligodendroglioma. Surg Neurol. 30(6):476-81, 1988
- Foster O et al: Syrinx associated with intramedullary metastasis. J Neurol Neurosurg Psychiatry. 50(8):1067-70, 1987
- Winkelman MD et al: Intramedullary spinal cord metastasis. Diagnostic and therapeutic considerations. Arch Neurol. 44(5):526-31, 1987
