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Spindle Cell Oncocytoma
Anne G. Osborn, MD, FACR; Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Spindle cell oncocytoma (SCO)
            • Synonyms

              • Spindle cell oncocytoma of adenohypophysis
            • Definitions

              • Oncocytoma
                • Nonadenomatous, nonendocrine, nonfunctioning sellar tumor
                • Thought to arise from folliculostellate cells of anterior pituitary
              • "Oncocytic" change/oncocytosis
                • Granular, eosinophilic histologic appearance
                  • Caused by presence of abundant intracytoplasmic mitochondria
              • "Oncocytes" = neoplastic oxyphil cells

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Mu Q et al: Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature. Mol Med Rep. ePub, 2015
                                      2. Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
                                      3. Rotman JA et al: Spindle cell oncocytoma of the adenohypophysis: a case report illustrating its natural history with 8-year observation and a review of the literature. Clin Imaging. 38(4):499-504, 2014
                                      4. Mete O et al: Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol. 37(11):1694-9, 2013
                                      5. Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
                                      6. Romero-Rojas AE et al: Spindle cell oncocytoma of the adenohypophysis. Brain Tumor Pathol. 28(4):359-64, 2011
                                      7. Borota OC et al: Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol. 28(2):91-5, 2009
                                      8. Demssie YN et al: Recurrent spindle cell oncocytoma of the pituitary, a case report and review of literature. Pituitary. Epub ahead of print, 2009
                                      9. Roncaroli F et al: Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: new tumor entities in the 2007 WHO Classification. Brain Pathol. 17(3):314-8, 2007
                                      10. Roncaroli F et al: 'Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol. 26(8):1048-55, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Spindle cell oncocytoma (SCO)
                                                • Synonyms

                                                  • Spindle cell oncocytoma of adenohypophysis
                                                • Definitions

                                                  • Oncocytoma
                                                    • Nonadenomatous, nonendocrine, nonfunctioning sellar tumor
                                                    • Thought to arise from folliculostellate cells of anterior pituitary
                                                  • "Oncocytic" change/oncocytosis
                                                    • Granular, eosinophilic histologic appearance
                                                      • Caused by presence of abundant intracytoplasmic mitochondria
                                                  • "Oncocytes" = neoplastic oxyphil cells

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • CT Findings

                                                      • MR Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Mu Q et al: Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature. Mol Med Rep. ePub, 2015
                                                                          2. Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
                                                                          3. Rotman JA et al: Spindle cell oncocytoma of the adenohypophysis: a case report illustrating its natural history with 8-year observation and a review of the literature. Clin Imaging. 38(4):499-504, 2014
                                                                          4. Mete O et al: Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol. 37(11):1694-9, 2013
                                                                          5. Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
                                                                          6. Romero-Rojas AE et al: Spindle cell oncocytoma of the adenohypophysis. Brain Tumor Pathol. 28(4):359-64, 2011
                                                                          7. Borota OC et al: Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol. 28(2):91-5, 2009
                                                                          8. Demssie YN et al: Recurrent spindle cell oncocytoma of the pituitary, a case report and review of literature. Pituitary. Epub ahead of print, 2009
                                                                          9. Roncaroli F et al: Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: new tumor entities in the 2007 WHO Classification. Brain Pathol. 17(3):314-8, 2007
                                                                          10. Roncaroli F et al: 'Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol. 26(8):1048-55, 2002