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Splenic Metastases and Lymphoma
Siva P. Raman, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      IMAGING

      • General Features

        • CT Findings

          • MR Findings

            • Ultrasonographic Findings

              • Angiographic Findings

                • Nuclear Medicine Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Boehnke MW et al: Imaging features of pathologically proven pediatric splenic masses. Pediatr Radiol. 50(9):1284-92, 2020
                                          2. Munakata W et al: Revised staging system for malignant lymphoma based on the Lugano classification. Jpn J Clin Oncol. 49(10):895-900, 2019
                                          3. Rowe SP et al: 3D CT cinematic rendering of the spleen: potential role in problem solving. Diagn Interv Imaging. 100(9):477-83, 2019
                                          4. Thipphavong S et al: Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. AJR Am J Roentgenol. 203(2):315-22, 2014
                                          5. Caremani M et al: Focal splenic lesions: US findings. J Ultrasound. 16(2):65-74, 2013
                                          6. Karlo CA et al: Computed tomography of the spleen: how to interpret the hypodense lesion. Insights Imaging. 4(1):65-76, 2013
                                          7. Trout AT et al: Melanoma metastases in the abdomen and pelvis: frequency and patterns of spread. World J Radiol. 5(2):25-32, 2013
                                          8. Saboo SS et al: Spleen in haematological malignancies: spectrum of imaging findings. Br J Radiol. 85(1009):81-92, 2012
                                          9. Kaushik C et al: Unusual CT and MR imaging characteristics of splenic lymphoma. Case Rep Oncol Med. 2011:298357, 2011
                                          10. Kaza RK et al: Primary and secondary neoplasms of the spleen. Cancer Imaging. 10:173-82, 2010
                                          11. Anis M et al: Imaging of abdominal lymphoma. Radiol Clin North Am. 46(2):265-85, viii-ix, 2008
                                          12. Lee WK et al: Abdominal manifestations of extranodal lymphoma: spectrum of imaging findings. AJR Am J Roentgenol. 191(1):198-206, 2008
                                          13. Leite NP et al: Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 27(6):1613-34, 2007
                                          14. Kamaya A et al: Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions. Semin Ultrasound CT MR. 27(5):389-403, 2006
                                          15. Elsayes KM et al: MR imaging of the spleen: spectrum of abnormalities. Radiographics. 25(4):967-82, 2005
                                          16. Urban BA et al: Helical CT of the spleen. AJR Am J Roentgenol. 170(4):997-1003, 1998
                                          17. Rabushka LS et al: Imaging of the spleen: CT with supplemental MR examination. Radiographics. 14(2):307-32, 1994
                                          18. Freeman JL et al: CT of congenital and acquired abnormalities of the spleen. Radiographics. 13(3):597-610, 1993
                                          19. Taylor AJ et al: CT of acquired abnormalities of the spleen. AJR Am J Roentgenol. 157(6):1213-9, 1991
                                          20. Hahn PF et al: MR imaging of focal splenic tumors. AJR Am J Roentgenol. 150(4):823-7, 1988
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Imaging

                                            • Top Differential Diagnoses

                                              IMAGING

                                              • General Features

                                                • CT Findings

                                                  • MR Findings

                                                    • Ultrasonographic Findings

                                                      • Angiographic Findings

                                                        • Nuclear Medicine Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Boehnke MW et al: Imaging features of pathologically proven pediatric splenic masses. Pediatr Radiol. 50(9):1284-92, 2020
                                                                                  2. Munakata W et al: Revised staging system for malignant lymphoma based on the Lugano classification. Jpn J Clin Oncol. 49(10):895-900, 2019
                                                                                  3. Rowe SP et al: 3D CT cinematic rendering of the spleen: potential role in problem solving. Diagn Interv Imaging. 100(9):477-83, 2019
                                                                                  4. Thipphavong S et al: Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. AJR Am J Roentgenol. 203(2):315-22, 2014
                                                                                  5. Caremani M et al: Focal splenic lesions: US findings. J Ultrasound. 16(2):65-74, 2013
                                                                                  6. Karlo CA et al: Computed tomography of the spleen: how to interpret the hypodense lesion. Insights Imaging. 4(1):65-76, 2013
                                                                                  7. Trout AT et al: Melanoma metastases in the abdomen and pelvis: frequency and patterns of spread. World J Radiol. 5(2):25-32, 2013
                                                                                  8. Saboo SS et al: Spleen in haematological malignancies: spectrum of imaging findings. Br J Radiol. 85(1009):81-92, 2012
                                                                                  9. Kaushik C et al: Unusual CT and MR imaging characteristics of splenic lymphoma. Case Rep Oncol Med. 2011:298357, 2011
                                                                                  10. Kaza RK et al: Primary and secondary neoplasms of the spleen. Cancer Imaging. 10:173-82, 2010
                                                                                  11. Anis M et al: Imaging of abdominal lymphoma. Radiol Clin North Am. 46(2):265-85, viii-ix, 2008
                                                                                  12. Lee WK et al: Abdominal manifestations of extranodal lymphoma: spectrum of imaging findings. AJR Am J Roentgenol. 191(1):198-206, 2008
                                                                                  13. Leite NP et al: Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 27(6):1613-34, 2007
                                                                                  14. Kamaya A et al: Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions. Semin Ultrasound CT MR. 27(5):389-403, 2006
                                                                                  15. Elsayes KM et al: MR imaging of the spleen: spectrum of abnormalities. Radiographics. 25(4):967-82, 2005
                                                                                  16. Urban BA et al: Helical CT of the spleen. AJR Am J Roentgenol. 170(4):997-1003, 1998
                                                                                  17. Rabushka LS et al: Imaging of the spleen: CT with supplemental MR examination. Radiographics. 14(2):307-32, 1994
                                                                                  18. Freeman JL et al: CT of congenital and acquired abnormalities of the spleen. Radiographics. 13(3):597-610, 1993
                                                                                  19. Taylor AJ et al: CT of acquired abnormalities of the spleen. AJR Am J Roentgenol. 157(6):1213-9, 1991
                                                                                  20. Hahn PF et al: MR imaging of focal splenic tumors. AJR Am J Roentgenol. 150(4):823-7, 1988