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Splenomegaly and Hypersplenism
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Splenomegaly (SMG)
              • Hypersplenism (HS)
            • Definitions

              • SMG: Splenic enlargement caused by a number of different underlying congestive, hematologic, inflammatory/infectious, neoplastic, or infiltrative disorders
              • Hypersplenism: Syndrome consisting of splenomegaly and pancytopenia in which bone marrow is either normal or hyperreactive

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              CLINICAL ISSUES

                              • Presentation

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Manenti A et al: Splenomegaly Secondary to Myeloproliferative Neoplasms and Portal Hypertension. Clin Lymphoma Myeloma Leuk. ePub, 2014
                                      2. Pozo AL et al: Splenomegaly: investigation, diagnosis and management. Blood Rev. 23(3):105-11, 2009
                                      3. Elsebae MM et al: A study of the effect of splenectomy on hepatic functional reserve and structural damage in patients with chronic hepatitis C virus infection by non-invasive serum markers. A prospective study. Int J Surg. 6(5):362-6, 2008
                                      4. Endo Y et al: Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. Surg Today. 38(12):1148-51, 2008
                                      5. Murata K et al: Splenectomy improves liver function in patients with liver cirrhosis. Hepatogastroenterology. 55(85):1407-11, 2008
                                      6. Brancatelli G et al: Fibropolycystic liver disease: CT and MR imaging findings. Radiographics. 25(3):659-70, 2005
                                      7. Peck-Radosavljevic M: Hypersplenism. Eur J Gastroenterol Hepatol. 13(4):317-23, 2001
                                      8. McCormick PA et al: Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. Baillieres Best Pract Res Clin Gastroenterol. 14(6):1009-31, 2000
                                      9. Paterson A et al: A pattern-oriented approach to splenic imaging in infants and children. Radiographics. 19(6):1465-85, 1999
                                      10. Bowdler AJ: Splenomegaly and hypersplenism. Clin Haematol. 12(2):467-88, 1983
                                      11. Mittelstaedt CA et al: Ultrasonic-pathologic classification of splenic abnormalities: gray-scale patterns. Radiology. 134(3):697-705, 1980
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Splenomegaly (SMG)
                                                  • Hypersplenism (HS)
                                                • Definitions

                                                  • SMG: Splenic enlargement caused by a number of different underlying congestive, hematologic, inflammatory/infectious, neoplastic, or infiltrative disorders
                                                  • Hypersplenism: Syndrome consisting of splenomegaly and pancytopenia in which bone marrow is either normal or hyperreactive

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Manenti A et al: Splenomegaly Secondary to Myeloproliferative Neoplasms and Portal Hypertension. Clin Lymphoma Myeloma Leuk. ePub, 2014
                                                                          2. Pozo AL et al: Splenomegaly: investigation, diagnosis and management. Blood Rev. 23(3):105-11, 2009
                                                                          3. Elsebae MM et al: A study of the effect of splenectomy on hepatic functional reserve and structural damage in patients with chronic hepatitis C virus infection by non-invasive serum markers. A prospective study. Int J Surg. 6(5):362-6, 2008
                                                                          4. Endo Y et al: Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. Surg Today. 38(12):1148-51, 2008
                                                                          5. Murata K et al: Splenectomy improves liver function in patients with liver cirrhosis. Hepatogastroenterology. 55(85):1407-11, 2008
                                                                          6. Brancatelli G et al: Fibropolycystic liver disease: CT and MR imaging findings. Radiographics. 25(3):659-70, 2005
                                                                          7. Peck-Radosavljevic M: Hypersplenism. Eur J Gastroenterol Hepatol. 13(4):317-23, 2001
                                                                          8. McCormick PA et al: Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. Baillieres Best Pract Res Clin Gastroenterol. 14(6):1009-31, 2000
                                                                          9. Paterson A et al: A pattern-oriented approach to splenic imaging in infants and children. Radiographics. 19(6):1465-85, 1999
                                                                          10. Bowdler AJ: Splenomegaly and hypersplenism. Clin Haematol. 12(2):467-88, 1983
                                                                          11. Mittelstaedt CA et al: Ultrasonic-pathologic classification of splenic abnormalities: gray-scale patterns. Radiology. 134(3):697-705, 1980