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Pediatrics
Diagnosis
Gastrointestinal
Liver Abnormalities
Steatosis/Steatohepatitis
Steatosis/Steatohepatitis
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Simple steatosis: Fatty infiltration of > 5% of hepatocytes
          • Nonalcoholic fatty liver disease (NAFLD): Steatosis with metabolic syndrome &/or abnormal liver function tests
          • Nonalcoholic steatohepatitis (NASH): Abnormal hepatic fat content with inflammatory activity or fibrosis

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Ultrasonographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • Staging, Grading, & Classification

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              Selected References

                              1. Mann JP et al: Paediatric non-alcoholic fatty liver disease: a practical overview for non-specialists. Arch Dis Child. 100(7):673-7, 2015
                              2. Towbin AJ et al: Magnetic resonance imaging of the pediatric liver: imaging of steatosis, iron deposition, and fibrosis. Magn Reson Imaging Clin N Am. 21(4):669-80, 2013
                              3. Chen J et al: Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology. 259(3):749-56, 2011
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Clinical Issues

                                    TERMINOLOGY

                                    • Definitions

                                      • Simple steatosis: Fatty infiltration of > 5% of hepatocytes
                                      • Nonalcoholic fatty liver disease (NAFLD): Steatosis with metabolic syndrome &/or abnormal liver function tests
                                      • Nonalcoholic steatohepatitis (NASH): Abnormal hepatic fat content with inflammatory activity or fibrosis

                                    IMAGING

                                    • General Features

                                      • CT Findings

                                        • MR Findings

                                          • Ultrasonographic Findings

                                            • Imaging Recommendations

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • Staging, Grading, & Classification

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          Selected References

                                                          1. Mann JP et al: Paediatric non-alcoholic fatty liver disease: a practical overview for non-specialists. Arch Dis Child. 100(7):673-7, 2015
                                                          2. Towbin AJ et al: Magnetic resonance imaging of the pediatric liver: imaging of steatosis, iron deposition, and fibrosis. Magn Reson Imaging Clin N Am. 21(4):669-80, 2013
                                                          3. Chen J et al: Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology. 259(3):749-56, 2011