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Subependymal Giant Cell Astrocytoma
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Subependymal giant cell astrocytoma (SGCA, SEGA)
            • Synonyms

              • Intraventricular astrocytoma of tuberous sclerosis complex
            • Definitions

              • Benign, slow-growing glioneuronal tumor arising near foramen of Monro in patient with tuberous sclerosis complex (TSC)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Fohlen M et al: Identification of TSC1 or TSC2 mutation limited to the tumor in three cases of solitary subependymal giant cell astrocytoma using next-generation sequencing technology. Childs Nerv Syst. ePub, 2020
                                              2. Cotter JA: An update on the central nervous system manifestations of tuberous sclerosis complex. Acta Neuropathol. 139(4):613-24, 2019
                                              3. Giordano F et al: Neurosurgical treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex: a series of 44 surgical procedures in 31 patients. Childs Nerv Syst. 36(5):951-60, 2019
                                              4. Hill BJ et al: Subependymal giant cell astrocytoma size measurement in tuberous sclerosis complex: noncontrast vs contrast-enhanced 3-dimensional T1-weighted magnetic resonance imaging (MRI). J Child Neurol. 34(14):922-7, 2019
                                              5. Jansen AC et al: Newly diagnosed and growing subependymal giant cell astrocytoma in adults with tuberous sclerosis complex: results from the International TOSCA Study. Front Neurol. 10:821, 2019
                                              6. Jansen AC et al: Clinical characteristics of subependymal giant cell astrocytoma in tuberous sclerosis complex. Front Neurol. 10:705, 2019
                                              7. Nguyen HS et al: Subependymal giant cell astrocytoma: a surveillance, epidemiology, and end results program-based analysis from 2004 to 2013. World Neurosurg. 118:e263-8, 2018
                                              8. Jiang T et al: Presurgical administration of mTOR inhibitors in patients with large subependymal giant cell astrocytoma associated with tuberous sclerosis complex. World Neurosurg. 107:1053.e1-1053.e6, 2017
                                              9. Beaumont TL et al: Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report. J Neurosurg Pediatr. 1-4, 2015
                                              10. Jóźwiak S et al: Natural history and current treatment options for subependymal giant cell astrocytoma in tuberous sclerosis complex. Semin Pediatr Neurol. 22(4):274-81, 2015
                                              11. Cardamone M et al: Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex. J Pediatr. 164(5):1195-200, 2014
                                              12. Harter DH et al: A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. J Neurosurg Pediatr. 13(1):21-8, 2014
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Subependymal giant cell astrocytoma (SGCA, SEGA)
                                                        • Synonyms

                                                          • Intraventricular astrocytoma of tuberous sclerosis complex
                                                        • Definitions

                                                          • Benign, slow-growing glioneuronal tumor arising near foramen of Monro in patient with tuberous sclerosis complex (TSC)

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Angiographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Fohlen M et al: Identification of TSC1 or TSC2 mutation limited to the tumor in three cases of solitary subependymal giant cell astrocytoma using next-generation sequencing technology. Childs Nerv Syst. ePub, 2020
                                                                                          2. Cotter JA: An update on the central nervous system manifestations of tuberous sclerosis complex. Acta Neuropathol. 139(4):613-24, 2019
                                                                                          3. Giordano F et al: Neurosurgical treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex: a series of 44 surgical procedures in 31 patients. Childs Nerv Syst. 36(5):951-60, 2019
                                                                                          4. Hill BJ et al: Subependymal giant cell astrocytoma size measurement in tuberous sclerosis complex: noncontrast vs contrast-enhanced 3-dimensional T1-weighted magnetic resonance imaging (MRI). J Child Neurol. 34(14):922-7, 2019
                                                                                          5. Jansen AC et al: Newly diagnosed and growing subependymal giant cell astrocytoma in adults with tuberous sclerosis complex: results from the International TOSCA Study. Front Neurol. 10:821, 2019
                                                                                          6. Jansen AC et al: Clinical characteristics of subependymal giant cell astrocytoma in tuberous sclerosis complex. Front Neurol. 10:705, 2019
                                                                                          7. Nguyen HS et al: Subependymal giant cell astrocytoma: a surveillance, epidemiology, and end results program-based analysis from 2004 to 2013. World Neurosurg. 118:e263-8, 2018
                                                                                          8. Jiang T et al: Presurgical administration of mTOR inhibitors in patients with large subependymal giant cell astrocytoma associated with tuberous sclerosis complex. World Neurosurg. 107:1053.e1-1053.e6, 2017
                                                                                          9. Beaumont TL et al: Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report. J Neurosurg Pediatr. 1-4, 2015
                                                                                          10. Jóźwiak S et al: Natural history and current treatment options for subependymal giant cell astrocytoma in tuberous sclerosis complex. Semin Pediatr Neurol. 22(4):274-81, 2015
                                                                                          11. Cardamone M et al: Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex. J Pediatr. 164(5):1195-200, 2014
                                                                                          12. Harter DH et al: A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. J Neurosurg Pediatr. 13(1):21-8, 2014