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Subependymal Giant Cell Astrocytoma
Anne G. Osborn, MD, FACR; John H. Rees, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Subependymal giant cell astrocytoma (SGCA, SEGA)
            • Synonyms

              • Intraventricular astrocytoma of tuberous sclerosis complex (TSC)
            • Definitions

              • Benign, slow-growing glioneuronal tumor arising near foramen of Monro in patient with tuberous sclerosis complex (TSC)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Beaumont TL et al: Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report. J Neurosurg Pediatr. 1-4, 2015
                                              2. Cardamone M et al: Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex. J Pediatr. 164(5):1195-200, 2014
                                              3. Harter DH et al: A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. J Neurosurg Pediatr. 13(1):21-8, 2014
                                              4. Kotulska K et al: Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients. Pediatr Neurol. 50(4):307-12, 2014
                                              5. Ouyang T et al: Subependymal giant cell astrocytoma: current concepts, management, and future directions. Childs Nerv Syst. 30(4):561-70, 2014
                                              6. Rovira À et al: Recommendations for the radiological diagnosis and follow-up of neuropathological abnormalities associated with tuberous sclerosis complex. J Neurooncol. 118(2):205-23, 2014
                                              7. Krueger DA et al: Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology. 80(6):574-80, 2013
                                              8. Roth J et al: Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012. Pediatr Neurol. 49(6):439-44, 2013
                                              9. Buccoliero AM et al: Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study. Neuropathology. 29(1):25-30, 2009
                                              10. Khayal IS et al: Characterization of low-grade gliomas using RGB color maps derived from ADC histograms. J Magn Reson Imaging. 30(1):209-13, 2009
                                              11. Voykov B et al: When tuberous sclerosis complex becomes an emergency. Can J Ophthalmol. 44(2):220-1, 2009
                                              12. Jozwiak J et al: Possible mechanisms of disease development in tuberous sclerosis. Lancet Oncol. 9(1):73-9, 2008
                                              13. Ess KC et al: Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. Neurology. 64(8):1446-9, 2005
                                              14. You H et al: Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma. J Neurooncol. 74(1):1-8, 2005
                                              15. Chan JA et al: Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 63(12):1236-42, 2004
                                              16. Cuccia V et al: Subependymal giant cell astrocytoma in children with tuberous sclerosis. Childs Nerv Syst. 19(4):232-43, 2003
                                              17. Rashidi M et al: Nonmalignant pediatric brain tumors. Curr Neurol Neurosci Rep. 3(3):200-5, 2003
                                              18. Sener RN: Diffusion MR imaging of giant cell tumors in tuberous sclerosis. J Comput Assist Tomogr. 27(3):431-3, 2003
                                              19. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                              20. Medhkour A et al: Neonatal subependymal giant cell astrocytoma. Pediatr Neurosurg. 36(5):271-4, 2002
                                              21. Nishio S et al: Tumours around the foramen of Monro: clinical and neuroimaging features and their differential diagnosis. J Clin Neurosci. 9(2):137-41, 2002
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Subependymal giant cell astrocytoma (SGCA, SEGA)
                                                        • Synonyms

                                                          • Intraventricular astrocytoma of tuberous sclerosis complex (TSC)
                                                        • Definitions

                                                          • Benign, slow-growing glioneuronal tumor arising near foramen of Monro in patient with tuberous sclerosis complex (TSC)

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Angiographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Beaumont TL et al: Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report. J Neurosurg Pediatr. 1-4, 2015
                                                                                          2. Cardamone M et al: Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex. J Pediatr. 164(5):1195-200, 2014
                                                                                          3. Harter DH et al: A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. J Neurosurg Pediatr. 13(1):21-8, 2014
                                                                                          4. Kotulska K et al: Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients. Pediatr Neurol. 50(4):307-12, 2014
                                                                                          5. Ouyang T et al: Subependymal giant cell astrocytoma: current concepts, management, and future directions. Childs Nerv Syst. 30(4):561-70, 2014
                                                                                          6. Rovira À et al: Recommendations for the radiological diagnosis and follow-up of neuropathological abnormalities associated with tuberous sclerosis complex. J Neurooncol. 118(2):205-23, 2014
                                                                                          7. Krueger DA et al: Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology. 80(6):574-80, 2013
                                                                                          8. Roth J et al: Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012. Pediatr Neurol. 49(6):439-44, 2013
                                                                                          9. Buccoliero AM et al: Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study. Neuropathology. 29(1):25-30, 2009
                                                                                          10. Khayal IS et al: Characterization of low-grade gliomas using RGB color maps derived from ADC histograms. J Magn Reson Imaging. 30(1):209-13, 2009
                                                                                          11. Voykov B et al: When tuberous sclerosis complex becomes an emergency. Can J Ophthalmol. 44(2):220-1, 2009
                                                                                          12. Jozwiak J et al: Possible mechanisms of disease development in tuberous sclerosis. Lancet Oncol. 9(1):73-9, 2008
                                                                                          13. Ess KC et al: Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. Neurology. 64(8):1446-9, 2005
                                                                                          14. You H et al: Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma. J Neurooncol. 74(1):1-8, 2005
                                                                                          15. Chan JA et al: Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 63(12):1236-42, 2004
                                                                                          16. Cuccia V et al: Subependymal giant cell astrocytoma in children with tuberous sclerosis. Childs Nerv Syst. 19(4):232-43, 2003
                                                                                          17. Rashidi M et al: Nonmalignant pediatric brain tumors. Curr Neurol Neurosci Rep. 3(3):200-5, 2003
                                                                                          18. Sener RN: Diffusion MR imaging of giant cell tumors in tuberous sclerosis. J Comput Assist Tomogr. 27(3):431-3, 2003
                                                                                          19. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                                                                          20. Medhkour A et al: Neonatal subependymal giant cell astrocytoma. Pediatr Neurosurg. 36(5):271-4, 2002
                                                                                          21. Nishio S et al: Tumours around the foramen of Monro: clinical and neuroimaging features and their differential diagnosis. J Clin Neurosci. 9(2):137-41, 2002