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Submandibular Gland Benign Mixed Tumor
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Submandibular gland (SMG) benign mixed tumor (BMT)
              • Synonyms

                • Pleomorphic adenoma
              • Definitions

                • Benign heterogeneous salivary gland primary tumor

              IMAGING

              • General Features

                • Submandibular sialography

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Kashiwagi N et al: Conventional MRI findings for predicting submandibular pleomorphic adenoma. Acta Radiol. 54(5):511-5, 2013
                                                  2. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                  3. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                  4. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                  5. Adeyemo WL et al: Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period. West Indian Med J. 58(4):388-91, 2009
                                                  6. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                  7. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                  8. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                                  9. Molina EJ et al: Pleomorphic adenoma of the submandibular gland. J Pediatr Surg. 43(6):1224-6, 2008
                                                  10. Roh JL et al: Gland-preserving surgery for pleomorphic adenoma in the submandibular gland. Br J Surg. 95(10):1252-6, 2008
                                                  11. Subhashraj K: Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg. 46(8):635-8, 2008
                                                  12. Rapidis AD et al: Tumors of the submandibular gland: clinicopathologic analysis of 23 patients. J Oral Maxillofac Surg. 62(10):1203-8, 2004
                                                  13. Pires FR et al: Synchronous mucoepidermoid carcinoma of tongue and pleomorphic adenoma of submandibular gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95(3):328-31, 2003
                                                  14. Alves FA et al: Pleomorphic adenoma of the submandibular gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg. 128(12):1400-3, 2002
                                                  15. Kawahara A et al: Characterization of the epithelial components in pleomorphic adenoma of the salivary gland. Acta Cytol. 46(6):1095-100, 2002
                                                  16. Morio T et al: DNA copy number changes in carcinoma in pleomorphic adenoma of the salivary gland: a comparative genomic hybridization study. Pathol Int. 52(8):501-7, 2002
                                                  17. Ohtake S et al: Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med. 31(10):590-7, 2002
                                                  18. Choi DS et al: Salivary gland tumors: evaluation with two-phase helical CT. Radiology. 214(1):231-6, 2000
                                                  19. Hirabayashi S: Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland. J Oral Pathol Med. 28(3):131-6, 1999
                                                  20. García CJ et al: Ultrasonography in the study of salivary gland lesions in children. Pediatr Radiol. 28(6):418-25, 1998
                                                  21. Heintz PW et al: Submandibular gland carcinoma ex pleomorphic adenoma. Report of a case with cytologic features and diagnostic pitfalls. Acta Cytol. 42(6):1431-6, 1998
                                                  22. Weissman JL et al: Anterior facial vein and submandibular gland together: predicting the histology of submandibular masses with CT or MR imaging. Radiology. 208(2):441-6, 1998
                                                  23. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                  24. Klijanienko J et al: Fine-needle sampling of salivary gland lesions. I. Cytology and histology correlation of 412 cases of pleomorphic adenoma. Diagn Cytopathol. 14(3):195-200, 1996
                                                  25. Lee SS et al: Differential diagnosis of adenoid cystic carcinoma from pleomorphic adenoma of the salivary gland on fine needle aspiration cytology. Acta Cytol. 40(6):1246-52, 1996
                                                  26. Kools PF et al: Identification of the chromosome 12 translocation breakpoint region of a pleomorphic salivary gland adenoma with t(1;12)(p22;q15) as the sole cytogenetic abnormality. Cancer Genet Cytogenet. 79(1):1-7, 1995
                                                  27. Cassidy M et al: Clear cell carcinoma arising in a pleomorphic adenoma of the submandibular gland. J Laryngol Otol. 108(6):529-32, 1994
                                                  28. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990
                                                  29. Mair S et al: Benign neurilemmoma (schwannoma) masquerading as a pleomorphic adenoma of the submandibular salivary gland. Acta Cytol. 33(6):907-10, 1989
                                                  30. Yamahara M et al: Phenotypic expression of human epidermal growth factor in foetal submandibular gland and pleomorphic adenoma of salivary gland. Virchows Arch A Pathol Anat Histopathol. 412(4):301-6, 1988
                                                  31. Guglielmo FF et al: CT findings in recurrent submandibular pleomorphic adenoma with metastasis. J Comput Assist Tomogr. 11(6):1098-100, 1987
                                                  32. Mark J et al: Polyclonal chromosomal evolution in a benign mixed salivary gland tumor. Cancer Genet Cytogenet. 28(2):237-43, 1987
                                                  33. Tandler B et al: Giant mitochondria in a pleomorphic adenoma of the submandibular gland. Ultrastruct Pathol. 4(1):85-96, 1983
                                                  34. David R et al: Langerhans' cells in a pleomorphic adenoma of submandibular salivary gland. J Pathol. 131(2):127-35, 1980
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Submandibular gland (SMG) benign mixed tumor (BMT)
                                                              • Synonyms

                                                                • Pleomorphic adenoma
                                                              • Definitions

                                                                • Benign heterogeneous salivary gland primary tumor

                                                              IMAGING

                                                              • General Features

                                                                • Submandibular sialography

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Ultrasonographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Kashiwagi N et al: Conventional MRI findings for predicting submandibular pleomorphic adenoma. Acta Radiol. 54(5):511-5, 2013
                                                                                                  2. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                                                                  3. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                                                                  4. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                                                                  5. Adeyemo WL et al: Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period. West Indian Med J. 58(4):388-91, 2009
                                                                                                  6. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                                                                  7. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                                                                  8. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                                                                                  9. Molina EJ et al: Pleomorphic adenoma of the submandibular gland. J Pediatr Surg. 43(6):1224-6, 2008
                                                                                                  10. Roh JL et al: Gland-preserving surgery for pleomorphic adenoma in the submandibular gland. Br J Surg. 95(10):1252-6, 2008
                                                                                                  11. Subhashraj K: Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg. 46(8):635-8, 2008
                                                                                                  12. Rapidis AD et al: Tumors of the submandibular gland: clinicopathologic analysis of 23 patients. J Oral Maxillofac Surg. 62(10):1203-8, 2004
                                                                                                  13. Pires FR et al: Synchronous mucoepidermoid carcinoma of tongue and pleomorphic adenoma of submandibular gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95(3):328-31, 2003
                                                                                                  14. Alves FA et al: Pleomorphic adenoma of the submandibular gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg. 128(12):1400-3, 2002
                                                                                                  15. Kawahara A et al: Characterization of the epithelial components in pleomorphic adenoma of the salivary gland. Acta Cytol. 46(6):1095-100, 2002
                                                                                                  16. Morio T et al: DNA copy number changes in carcinoma in pleomorphic adenoma of the salivary gland: a comparative genomic hybridization study. Pathol Int. 52(8):501-7, 2002
                                                                                                  17. Ohtake S et al: Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med. 31(10):590-7, 2002
                                                                                                  18. Choi DS et al: Salivary gland tumors: evaluation with two-phase helical CT. Radiology. 214(1):231-6, 2000
                                                                                                  19. Hirabayashi S: Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland. J Oral Pathol Med. 28(3):131-6, 1999
                                                                                                  20. García CJ et al: Ultrasonography in the study of salivary gland lesions in children. Pediatr Radiol. 28(6):418-25, 1998
                                                                                                  21. Heintz PW et al: Submandibular gland carcinoma ex pleomorphic adenoma. Report of a case with cytologic features and diagnostic pitfalls. Acta Cytol. 42(6):1431-6, 1998
                                                                                                  22. Weissman JL et al: Anterior facial vein and submandibular gland together: predicting the histology of submandibular masses with CT or MR imaging. Radiology. 208(2):441-6, 1998
                                                                                                  23. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                                                                  24. Klijanienko J et al: Fine-needle sampling of salivary gland lesions. I. Cytology and histology correlation of 412 cases of pleomorphic adenoma. Diagn Cytopathol. 14(3):195-200, 1996
                                                                                                  25. Lee SS et al: Differential diagnosis of adenoid cystic carcinoma from pleomorphic adenoma of the salivary gland on fine needle aspiration cytology. Acta Cytol. 40(6):1246-52, 1996
                                                                                                  26. Kools PF et al: Identification of the chromosome 12 translocation breakpoint region of a pleomorphic salivary gland adenoma with t(1;12)(p22;q15) as the sole cytogenetic abnormality. Cancer Genet Cytogenet. 79(1):1-7, 1995
                                                                                                  27. Cassidy M et al: Clear cell carcinoma arising in a pleomorphic adenoma of the submandibular gland. J Laryngol Otol. 108(6):529-32, 1994
                                                                                                  28. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990
                                                                                                  29. Mair S et al: Benign neurilemmoma (schwannoma) masquerading as a pleomorphic adenoma of the submandibular salivary gland. Acta Cytol. 33(6):907-10, 1989
                                                                                                  30. Yamahara M et al: Phenotypic expression of human epidermal growth factor in foetal submandibular gland and pleomorphic adenoma of salivary gland. Virchows Arch A Pathol Anat Histopathol. 412(4):301-6, 1988
                                                                                                  31. Guglielmo FF et al: CT findings in recurrent submandibular pleomorphic adenoma with metastasis. J Comput Assist Tomogr. 11(6):1098-100, 1987
                                                                                                  32. Mark J et al: Polyclonal chromosomal evolution in a benign mixed salivary gland tumor. Cancer Genet Cytogenet. 28(2):237-43, 1987
                                                                                                  33. Tandler B et al: Giant mitochondria in a pleomorphic adenoma of the submandibular gland. Ultrastruct Pathol. 4(1):85-96, 1983
                                                                                                  34. David R et al: Langerhans' cells in a pleomorphic adenoma of submandibular salivary gland. J Pathol. 131(2):127-35, 1980