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Head and Neck
Diagnosis
Oral Cavity
Malignant Tumors
Submandibular Gland Carcinoma
Submandibular Gland Carcinoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Submandibular gland (SMG) carcinoma

              • Definitions

                • Primary malignancy arising in SMG
                  • Most commonly adenoid cystic carcinoma (ACCa), mucoepidermoid carcinoma (MECa), adenocarcinoma (AdCa)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Ultrasonographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Ogle OE: Salivary gland diseases. Dent Clin North Am. 64(1):87-104, 2020
                                                  2. Wang H et al: Salivary gland NUT carcinoma with prolonged survival in children: case illustration and systematic review of literature. Head Neck Pathol. 15(1):236-43, 2020
                                                  3. Şahin MM et al: Submandibular gland cancers: prognostic factors and survival analysis. Eur Arch Otorhinolaryngol. 277(8):2307-13., 2020
                                                  4. Hernandez-Prera JC et al: Macrocystic (mammary analogue) secretory carcinoma: an unusual variant and a pitfall in the differential diagnosis of cystic lesions in the head and neck. Am J Surg Pathol. 43(11):1483-92, 2019
                                                  5. Ikeda R et al: Malignancies in patients with IgG4-related diseases in head and neck regions. Tohoku J Exp Med. 249(4):285-90, 2019
                                                  6. Larson CR et al: FDG-PET imaging of salivary gland tumors. Semin Ultrasound CT MR. 40(5):391-9, 2019
                                                  7. Lubin D et al: The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland. Diagn Cytopathol. 47(6):617-36, 2019
                                                  8. Munhoz L et al: Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(3):280-310, 2019
                                                  9. Oren N et al: Updated WHO nomenclature of head and neck lesions and associated imaging findings. Insights Imaging. 10(1):72, 2019
                                                  10. Saxena S et al: Swelling of the submandibular gland region: cystic or neoplastic entity? J Oral Maxillofac Pathol. 23(3):468-71, 2019
                                                  11. Coupland A et al: Adenoid cystic carcinoma of the submandibular gland, locoregional recurrence, and a solitary liver metastasis more than 30 years since primary diagnosis. Case Rep Surg. 2014:581823, 2014
                                                  12. Fernandes H et al: Role of FNAC in the preoperative diagnosis of salivary gland lesions. J Clin Diagn Res. 8(9):FC01-3, 2014
                                                  13. Zhang G et al: CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands. Int J Clin Exp Pathol. 7(3):1004-11, 2014
                                                  14. Weon YC et al: Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients. Neuroradiology. 54(6):631-40, 2012
                                                  15. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                  16. Craver RD et al: Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a Children's Hospital. Pediatr Dev Pathol. 13(5):348-53, 2010
                                                  17. Maiuri F et al: Intracranial extension of salivary gland tumors. Clin Neuropathol. 29(1):9-13, 2010
                                                  18. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                  19. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                  20. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                  21. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                  22. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                  23. Kruse A et al: Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg. 20(6):2024-7, 2009
                                                  24. Kshirsagar AY et al: Mixed malignant tumor of the submandibular gland. Int Surg. 94(3):237-9, 2009
                                                  25. Roh JL et al: Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol. 97(6):533-7, 2008
                                                  26. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                                  27. Cohen AN et al: Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg. 131(6):994-1000, 2004
                                                  28. de Vicente Rodriguez JC et al: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann Otol Rhinol Laryngol. 113(1):55-9, 2004
                                                  29. Li CH et al: Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium. J Laryngol Otol. 117(9):731-3, 2003
                                                  30. Toyoda H et al: Salivary duct carcinoma in the submandibular region. Int J Oral Maxillofac Surg. 32(4):427-9, 2003
                                                  31. Camilleri IG et al: Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg. 51(3):181-5, 1998
                                                  32. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                  33. Renehan A et al: Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg. 83(12):1750-4, 1996
                                                  34. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Submandibular gland (SMG) carcinoma

                                                              • Definitions

                                                                • Primary malignancy arising in SMG
                                                                  • Most commonly adenoid cystic carcinoma (ACCa), mucoepidermoid carcinoma (MECa), adenocarcinoma (AdCa)

                                                              IMAGING

                                                              • General Features

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Ultrasonographic Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Ogle OE: Salivary gland diseases. Dent Clin North Am. 64(1):87-104, 2020
                                                                                                  2. Wang H et al: Salivary gland NUT carcinoma with prolonged survival in children: case illustration and systematic review of literature. Head Neck Pathol. 15(1):236-43, 2020
                                                                                                  3. Şahin MM et al: Submandibular gland cancers: prognostic factors and survival analysis. Eur Arch Otorhinolaryngol. 277(8):2307-13., 2020
                                                                                                  4. Hernandez-Prera JC et al: Macrocystic (mammary analogue) secretory carcinoma: an unusual variant and a pitfall in the differential diagnosis of cystic lesions in the head and neck. Am J Surg Pathol. 43(11):1483-92, 2019
                                                                                                  5. Ikeda R et al: Malignancies in patients with IgG4-related diseases in head and neck regions. Tohoku J Exp Med. 249(4):285-90, 2019
                                                                                                  6. Larson CR et al: FDG-PET imaging of salivary gland tumors. Semin Ultrasound CT MR. 40(5):391-9, 2019
                                                                                                  7. Lubin D et al: The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland. Diagn Cytopathol. 47(6):617-36, 2019
                                                                                                  8. Munhoz L et al: Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(3):280-310, 2019
                                                                                                  9. Oren N et al: Updated WHO nomenclature of head and neck lesions and associated imaging findings. Insights Imaging. 10(1):72, 2019
                                                                                                  10. Saxena S et al: Swelling of the submandibular gland region: cystic or neoplastic entity? J Oral Maxillofac Pathol. 23(3):468-71, 2019
                                                                                                  11. Coupland A et al: Adenoid cystic carcinoma of the submandibular gland, locoregional recurrence, and a solitary liver metastasis more than 30 years since primary diagnosis. Case Rep Surg. 2014:581823, 2014
                                                                                                  12. Fernandes H et al: Role of FNAC in the preoperative diagnosis of salivary gland lesions. J Clin Diagn Res. 8(9):FC01-3, 2014
                                                                                                  13. Zhang G et al: CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands. Int J Clin Exp Pathol. 7(3):1004-11, 2014
                                                                                                  14. Weon YC et al: Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients. Neuroradiology. 54(6):631-40, 2012
                                                                                                  15. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                                                                  16. Craver RD et al: Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a Children's Hospital. Pediatr Dev Pathol. 13(5):348-53, 2010
                                                                                                  17. Maiuri F et al: Intracranial extension of salivary gland tumors. Clin Neuropathol. 29(1):9-13, 2010
                                                                                                  18. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                                                                  19. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                                                                  20. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                                                                  21. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                                                                  22. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                                                                  23. Kruse A et al: Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg. 20(6):2024-7, 2009
                                                                                                  24. Kshirsagar AY et al: Mixed malignant tumor of the submandibular gland. Int Surg. 94(3):237-9, 2009
                                                                                                  25. Roh JL et al: Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol. 97(6):533-7, 2008
                                                                                                  26. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                                                                                  27. Cohen AN et al: Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg. 131(6):994-1000, 2004
                                                                                                  28. de Vicente Rodriguez JC et al: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann Otol Rhinol Laryngol. 113(1):55-9, 2004
                                                                                                  29. Li CH et al: Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium. J Laryngol Otol. 117(9):731-3, 2003
                                                                                                  30. Toyoda H et al: Salivary duct carcinoma in the submandibular region. Int J Oral Maxillofac Surg. 32(4):427-9, 2003
                                                                                                  31. Camilleri IG et al: Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg. 51(3):181-5, 1998
                                                                                                  32. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                                                                  33. Renehan A et al: Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg. 83(12):1750-4, 1996
                                                                                                  34. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990