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Submandibular Gland Carcinoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Submandibular gland (SMG) carcinoma
                • Adenoid cystic carcinoma (ACCa)
                • Mucoepidermoid carcinoma (MECa)
                • Adenocarcinoma (AdCa)
              • Definitions

                • Primary malignancy arising in SMG
                  • Most commonly ACCa, MECa, AdCa

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Ultrasonographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Coupland A et al: Adenoid cystic carcinoma of the submandibular gland, locoregional recurrence, and a solitary liver metastasis more than 30 years since primary diagnosis. Case Rep Surg. 2014:581823, 2014
                                                  2. Fernandes H et al: Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions. J Clin Diagn Res. 8(9):FC01-3, 2014
                                                  3. Zhang G et al: CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands. Int J Clin Exp Pathol. 7(3):1004-11, 2014
                                                  4. Weon YC et al: Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients. Neuroradiology. 54(6):631-40, 2012
                                                  5. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                  6. Craver RD et al: Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children's Hospital. Pediatr Dev Pathol. Epub ahead of print, 2010
                                                  7. Maiuri F et al: Intracranial extension of salivary gland tumors. Clin Neuropathol. 29(1):9-13, 2010
                                                  8. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                  9. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                  10. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                  11. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                  12. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                  13. Kruse A et al: Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg. 20(6):2024-7, 2009
                                                  14. Kshirsagar AY et al: Mixed malignant tumor of the submandibular gland. Int Surg. 94(3):237-9, 2009
                                                  15. Roh JL et al: Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol. 97(6):533-7, 2008
                                                  16. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                                  17. Cohen AN et al: Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg. 131(6):994-1000, 2004
                                                  18. de Vicente Rodriguez JC et al: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann Otol Rhinol Laryngol. 113(1):55-9, 2004
                                                  19. Li CH et al: Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium. J Laryngol Otol. 117(9):731-3, 2003
                                                  20. Toyoda H et al: Salivary duct carcinoma in the submandibular region. Int J Oral Maxillofac Surg. 32(4):427-9, 2003
                                                  21. Camilleri IG et al: Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg. 51(3):181-5, 1998
                                                  22. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                  23. Renehan A et al: Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg. 83(12):1750-4, 1996
                                                  24. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Submandibular gland (SMG) carcinoma
                                                                • Adenoid cystic carcinoma (ACCa)
                                                                • Mucoepidermoid carcinoma (MECa)
                                                                • Adenocarcinoma (AdCa)
                                                              • Definitions

                                                                • Primary malignancy arising in SMG
                                                                  • Most commonly ACCa, MECa, AdCa

                                                              IMAGING

                                                              • General Features

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Ultrasonographic Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Coupland A et al: Adenoid cystic carcinoma of the submandibular gland, locoregional recurrence, and a solitary liver metastasis more than 30 years since primary diagnosis. Case Rep Surg. 2014:581823, 2014
                                                                                                  2. Fernandes H et al: Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions. J Clin Diagn Res. 8(9):FC01-3, 2014
                                                                                                  3. Zhang G et al: CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands. Int J Clin Exp Pathol. 7(3):1004-11, 2014
                                                                                                  4. Weon YC et al: Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients. Neuroradiology. 54(6):631-40, 2012
                                                                                                  5. Chua DY et al: Submandibular mass excision in an Asian population: a 10-year review. Ann Acad Med Singapore. 39(1):33-7, 2010
                                                                                                  6. Craver RD et al: Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children's Hospital. Pediatr Dev Pathol. Epub ahead of print, 2010
                                                                                                  7. Maiuri F et al: Intracranial extension of salivary gland tumors. Clin Neuropathol. 29(1):9-13, 2010
                                                                                                  8. Tian Z et al: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39(3):235-42, 2010
                                                                                                  9. Ziglinas P et al: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol. 46(4):287-91, 2010
                                                                                                  10. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                                                                  11. Isa AY et al: An evidence based approach to the management of salivary masses. Clin Otolaryngol. 34(5):470-3, 2009
                                                                                                  12. Kei PL et al: CT "invisible" lesion of the major salivary glands a diagnostic pitfall of contrast-enhanced CT. Clin Radiol. 64(7):744-6, 2009
                                                                                                  13. Kruse A et al: Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg. 20(6):2024-7, 2009
                                                                                                  14. Kshirsagar AY et al: Mixed malignant tumor of the submandibular gland. Int Surg. 94(3):237-9, 2009
                                                                                                  15. Roh JL et al: Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol. 97(6):533-7, 2008
                                                                                                  16. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                                                                                  17. Cohen AN et al: Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg. 131(6):994-1000, 2004
                                                                                                  18. de Vicente Rodriguez JC et al: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann Otol Rhinol Laryngol. 113(1):55-9, 2004
                                                                                                  19. Li CH et al: Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium. J Laryngol Otol. 117(9):731-3, 2003
                                                                                                  20. Toyoda H et al: Salivary duct carcinoma in the submandibular region. Int J Oral Maxillofac Surg. 32(4):427-9, 2003
                                                                                                  21. Camilleri IG et al: Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg. 51(3):181-5, 1998
                                                                                                  22. Kaneda T et al: MR of the submandibular gland: normal and pathologic states. AJNR Am J Neuroradiol. 17(8):1575-81, 1996
                                                                                                  23. Renehan A et al: Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg. 83(12):1750-4, 1996
                                                                                                  24. Weber RS et al: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg. 116(9):1055-60, 1990