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Submandibular Space Nodal Non-Hodgkin Lymphoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Submandibular space (SMS) nodal non-Hodgkin lymphoma (NHL)
              • Definitions

                • NHL = lymphoreticular system malignancy, postulated to arise from lymphocytes & derivatives
                • H&N NHL has 3 main forms: Nodal, non-nodal lymphatic (Waldeyer ring), & non-nodal extralymphatic (e.g., thyroid, lacrimal)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Houldcroft CJ et al: Host genetics of Epstein-Barr virus infection, latency and disease. Rev Med Virol. 25(2):71-84, 2015
                                                2. Fueger BJ et al: Comparison of CT, PET, and PET/CT for staging of patients with indolent non-Hodgkin's lymphoma. Mol Imaging Biol. 11(4):269-74, 2009
                                                3. Mahmood NS et al: Multiple 'lumps' and 'bumps' in the head with bilateral proptosis: a unique presentation of systemic non-Hodgkin's lymphoma. Pediatr Neurosurg. 45(6):481-2, 2009
                                                4. Taylor CR: The WHO classification of lymphomas: cost-effective immunohistochemistry using a deductive reasoning "decision tree" approach: part II: the decision tree approach: diffuse patterns of proliferation in lymph nodes. Appl Immunohistochem Mol Morphol. 17(6):470-82, 2009
                                                5. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                                6. Nathu RM et al: Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. Head Neck. 21(3):247-54, 1999
                                                7. Harnsberger HR et al: Non-Hodgkin's lymphoma of the head and neck: CT evaluation of nodal and extranodal sites. AJR Am J Roentgenol. 149(4):785-91, 1987
                                                8. Lee YY et al: Lymphomas of the head and neck: CT findings at initial presentation. AJR Am J Roentgenol. 149(3):575-81, 1987
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Submandibular space (SMS) nodal non-Hodgkin lymphoma (NHL)
                                                            • Definitions

                                                              • NHL = lymphoreticular system malignancy, postulated to arise from lymphocytes & derivatives
                                                              • H&N NHL has 3 main forms: Nodal, non-nodal lymphatic (Waldeyer ring), & non-nodal extralymphatic (e.g., thyroid, lacrimal)

                                                            IMAGING

                                                            • General Features

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Houldcroft CJ et al: Host genetics of Epstein-Barr virus infection, latency and disease. Rev Med Virol. 25(2):71-84, 2015
                                                                                              2. Fueger BJ et al: Comparison of CT, PET, and PET/CT for staging of patients with indolent non-Hodgkin's lymphoma. Mol Imaging Biol. 11(4):269-74, 2009
                                                                                              3. Mahmood NS et al: Multiple 'lumps' and 'bumps' in the head with bilateral proptosis: a unique presentation of systemic non-Hodgkin's lymphoma. Pediatr Neurosurg. 45(6):481-2, 2009
                                                                                              4. Taylor CR: The WHO classification of lymphomas: cost-effective immunohistochemistry using a deductive reasoning "decision tree" approach: part II: the decision tree approach: diffuse patterns of proliferation in lymph nodes. Appl Immunohistochem Mol Morphol. 17(6):470-82, 2009
                                                                                              5. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                                                                              6. Nathu RM et al: Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. Head Neck. 21(3):247-54, 1999
                                                                                              7. Harnsberger HR et al: Non-Hodgkin's lymphoma of the head and neck: CT evaluation of nodal and extranodal sites. AJR Am J Roentgenol. 149(4):785-91, 1987
                                                                                              8. Lee YY et al: Lymphomas of the head and neck: CT findings at initial presentation. AJR Am J Roentgenol. 149(3):575-81, 1987