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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Superficial siderosis (SS)
- Cortical SS (cSS)
Synonyms
- Superficial cortical hemosiderosis
Definitions
- SS
- Hemosiderin deposition along pial surfaces of brain, cranial nerves, spinal cord
- 2 types of SS now recognized
- Classic/infratentorial SS
- Primarily posterior fossa, spinal cord
- cSS
- SS limited to cortex over hemisphere convexities
- Classic/infratentorial SS
- SS
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Pongpitakmetha T et al: Cortical superficial siderosis progression in cerebral amyloid angiopathy: prospective MRI study. Neurology. 94(17):e1853-65, 2020
- Charidimou A et al: APOE and cortical superficial siderosis in CAA: meta-analysis and potential mechanisms. Neurology. 93(4):e358-71, 2019
- Charidimou A et al: Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: large prospective cohort and preliminary meta-analysis. Int J Stroke. 14(7):723-33, 2019
- Charidimou A et al: Cortical superficial siderosis evolution. Stroke. 50(4):954-62, 2019
- Wollenweber FA et al: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology. 92(8):e792-e801, 2019
- Banerjee G et al: Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke. 49(1):40-5, 2018
- Charidimou A et al: Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology. 88(17):1607-14, 2017
- Charidimou A et al: Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: a prospective study. Neurology. 89(21):2128-35, 2017
- Wilson D et al: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. J Neurol. 264(4):664-73, 2017
- Charidimou A: Cortical superficial siderosis presumed due to cerebral amyloid angiopathy: minimum standards for rating and reporting. AJNR Am J Neuroradiol. 37(5):E43-4, 2016
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Superficial siderosis (SS)
- Cortical SS (cSS)
Synonyms
- Superficial cortical hemosiderosis
Definitions
- SS
- Hemosiderin deposition along pial surfaces of brain, cranial nerves, spinal cord
- 2 types of SS now recognized
- Classic/infratentorial SS
- Primarily posterior fossa, spinal cord
- cSS
- SS limited to cortex over hemisphere convexities
- Classic/infratentorial SS
- SS
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Pongpitakmetha T et al: Cortical superficial siderosis progression in cerebral amyloid angiopathy: prospective MRI study. Neurology. 94(17):e1853-65, 2020
- Charidimou A et al: APOE and cortical superficial siderosis in CAA: meta-analysis and potential mechanisms. Neurology. 93(4):e358-71, 2019
- Charidimou A et al: Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: large prospective cohort and preliminary meta-analysis. Int J Stroke. 14(7):723-33, 2019
- Charidimou A et al: Cortical superficial siderosis evolution. Stroke. 50(4):954-62, 2019
- Wollenweber FA et al: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology. 92(8):e792-e801, 2019
- Banerjee G et al: Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke. 49(1):40-5, 2018
- Charidimou A et al: Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology. 88(17):1607-14, 2017
- Charidimou A et al: Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: a prospective study. Neurology. 89(21):2128-35, 2017
- Wilson D et al: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. J Neurol. 264(4):664-73, 2017
- Charidimou A: Cortical superficial siderosis presumed due to cerebral amyloid angiopathy: minimum standards for rating and reporting. AJNR Am J Neuroradiol. 37(5):E43-4, 2016
