Hemosiderin deposition along pial surfaces of brain, cranial nerves, spinal cord
2 types of SS now recognized
Classic/infratentorial SS
Primarily posterior fossa, spinal cord
cSS
SS limited to cortex over hemisphere convexities
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Pongpitakmetha T et al: Cortical superficial siderosis progression in cerebral amyloid angiopathy: prospective MRI study. Neurology. 94(17):e1853-65, 2020
Charidimou A et al: APOE and cortical superficial siderosis in CAA: meta-analysis and potential mechanisms. Neurology. 93(4):e358-71, 2019
Charidimou A et al: Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: large prospective cohort and preliminary meta-analysis. Int J Stroke. 14(7):723-33, 2019
Charidimou A et al: Cortical superficial siderosis evolution. Stroke. 50(4):954-62, 2019
Wollenweber FA et al: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology. 92(8):e792-e801, 2019
Banerjee G et al: Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke. 49(1):40-5, 2018
Charidimou A et al: Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology. 88(17):1607-14, 2017
Charidimou A et al: Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: a prospective study. Neurology. 89(21):2128-35, 2017
Wilson D et al: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. J Neurol. 264(4):664-73, 2017
Charidimou A: Cortical superficial siderosis presumed due to cerebral amyloid angiopathy: minimum standards for rating and reporting. AJNR Am J Neuroradiol. 37(5):E43-4, 2016
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Superficial siderosis (SS)
Cortical SS (cSS)
Synonyms
Superficial cortical hemosiderosis
Definitions
SS
Hemosiderin deposition along pial surfaces of brain, cranial nerves, spinal cord
2 types of SS now recognized
Classic/infratentorial SS
Primarily posterior fossa, spinal cord
cSS
SS limited to cortex over hemisphere convexities
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Pongpitakmetha T et al: Cortical superficial siderosis progression in cerebral amyloid angiopathy: prospective MRI study. Neurology. 94(17):e1853-65, 2020
Charidimou A et al: APOE and cortical superficial siderosis in CAA: meta-analysis and potential mechanisms. Neurology. 93(4):e358-71, 2019
Charidimou A et al: Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: large prospective cohort and preliminary meta-analysis. Int J Stroke. 14(7):723-33, 2019
Charidimou A et al: Cortical superficial siderosis evolution. Stroke. 50(4):954-62, 2019
Wollenweber FA et al: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology. 92(8):e792-e801, 2019
Banerjee G et al: Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke. 49(1):40-5, 2018
Charidimou A et al: Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology. 88(17):1607-14, 2017
Charidimou A et al: Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: a prospective study. Neurology. 89(21):2128-35, 2017
Wilson D et al: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. J Neurol. 264(4):664-73, 2017
Charidimou A: Cortical superficial siderosis presumed due to cerebral amyloid angiopathy: minimum standards for rating and reporting. AJNR Am J Neuroradiol. 37(5):E43-4, 2016
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