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Superficial Siderosis
Anne G. Osborn, MD, FACR; H. Ric Harnsberger, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Abbreviations

            • Superficial siderosis (SS), subarachnoid hemorrhage (SAH)
          • Synonyms

            • Siderosis, central nervous system siderosis
          • Definitions

            • Chronic, recurrent SAH → hemosiderin deposition on pial surfaces of brain, brainstem, cranial nerves (CNs), spinal cord

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      • Reporting Tips

                                        Selected References

                                        1. Calvo M et al: [Diffuse superficial siderosis of the central nervous system: four case reports and review of the literature.] Rev Neurol. 59(8):354-8, 2014
                                        2. Pikis S et al: Superficial siderosis of the central nervous system secondary to spinal ependymoma. J Clin Neurosci. ePub, 2014
                                        3. Charidimou A et al: Cortical superficial siderosis and intracerebral hemorrhage risk in cerebral amyloid angiopathy. Neurology. 81(19):1666-73, 2013
                                        4. Posti JP et al: Three cases of superficial siderosis of the central nervous system and review of the literature. Acta Neurochir (Wien). 153(10):2067-73, 2011
                                        5. Wang J et al: Superficial siderosis of the central nervous system: MR findings with susceptibility-weighted imaging. Clin Imaging. 35(3):217-21, 2011
                                        6. Kumar N: Neuroimaging in superficial siderosis: an in-depth look. AJNR Am J Neuroradiol. 31(1):5-14, 2010
                                        7. Koeppen AH et al: The pathology of superficial siderosis of the central nervous system. Acta Neuropathol. 116(4):371-82, 2008
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Superficial siderosis (SS), subarachnoid hemorrhage (SAH)
                                                • Synonyms

                                                  • Siderosis, central nervous system siderosis
                                                • Definitions

                                                  • Chronic, recurrent SAH → hemosiderin deposition on pial surfaces of brain, brainstem, cranial nerves (CNs), spinal cord

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          • Image Interpretation Pearls

                                                                            • Reporting Tips

                                                                              Selected References

                                                                              1. Calvo M et al: [Diffuse superficial siderosis of the central nervous system: four case reports and review of the literature.] Rev Neurol. 59(8):354-8, 2014
                                                                              2. Pikis S et al: Superficial siderosis of the central nervous system secondary to spinal ependymoma. J Clin Neurosci. ePub, 2014
                                                                              3. Charidimou A et al: Cortical superficial siderosis and intracerebral hemorrhage risk in cerebral amyloid angiopathy. Neurology. 81(19):1666-73, 2013
                                                                              4. Posti JP et al: Three cases of superficial siderosis of the central nervous system and review of the literature. Acta Neurochir (Wien). 153(10):2067-73, 2011
                                                                              5. Wang J et al: Superficial siderosis of the central nervous system: MR findings with susceptibility-weighted imaging. Clin Imaging. 35(3):217-21, 2011
                                                                              6. Kumar N: Neuroimaging in superficial siderosis: an in-depth look. AJNR Am J Neuroradiol. 31(1):5-14, 2010
                                                                              7. Koeppen AH et al: The pathology of superficial siderosis of the central nervous system. Acta Neuropathol. 116(4):371-82, 2008