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Superior Prefrontal Cortex (Area 8)
Jeffrey S. Anderson, MD, PhD; Jared A. Nielsen, PhD
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Location and Boundaries

  • Location

    • Boundaries

      Function

      • Theory of Mind

        • Simulating Future Events

          • Self-Referential Processes

            Structural Connections

            • Cortical

              • Subcortical

                Functional Connections

                • Coactive Regions

                  • Associated Literature Keywords (NeuroSynth)

                    Area 8-Associated Disorders

                    • Alzheimer Disease

                      • Autism

                        • Major Depressive Disorder

                          Selected References

                          1. Harrison BJ et al: Human ventromedial prefrontal cortex and the positive affective processing of safety signals. Neuroimage. 152:12-8, 2017
                          2. Wegrzyn M et al: Auditory attention enhances processing of positive and negative words in inferior and superior prefrontal cortex. Cortex. 96:31-45, 2017
                          3. Hassabis D et al: Imagine all the people: how the brain creates and uses personality models to predict behavior. Cereb Cortex. 24(8):1979-87, 2014
                          4. Laurent HK et al: A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry. Soc Cogn Affect Neurosci. 7(2):125-34, 2012
                          5. Samson F et al: Enhanced visual functioning in autism: an ALE meta-analysis. Hum Brain Mapp. 33(7):1553-81, 2012
                          6. Spreng RN et al: I remember you: a role for memory in social cognition and the functional neuroanatomy of their interaction. Brain Res. 1428:43-50, 2012
                          7. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                          8. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                          9. Andrews-Hanna JR et al: Functional-anatomic fractionation of the brain's default network. Neuron. 65(4):550-62, 2010
                          10. Spreng RN et al: Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition. Neuroimage. 53(1):303-17, 2010
                          11. Spreng RN et al: Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network. J Cogn Neurosci. 22(6):1112-23, 2010
                          12. Buckner RL et al: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 29(6):1860-73, 2009
                          13. Spreng RN et al: The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis. J Cogn Neurosci. 21(3):489-510, 2009
                          14. Buckner RL et al: The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38, 2008
                          15. Buckner RL et al: Self-projection and the brain. Trends Cogn Sci. 11(2):49-57, 2007
                          16. Buckner RL et al: Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 25(34):7709-17, 2005
                          17. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          Location and Boundaries

                          • Location

                            • Boundaries

                              Function

                              • Theory of Mind

                                • Simulating Future Events

                                  • Self-Referential Processes

                                    Structural Connections

                                    • Cortical

                                      • Subcortical

                                        Functional Connections

                                        • Coactive Regions

                                          • Associated Literature Keywords (NeuroSynth)

                                            Area 8-Associated Disorders

                                            • Alzheimer Disease

                                              • Autism

                                                • Major Depressive Disorder

                                                  Selected References

                                                  1. Harrison BJ et al: Human ventromedial prefrontal cortex and the positive affective processing of safety signals. Neuroimage. 152:12-8, 2017
                                                  2. Wegrzyn M et al: Auditory attention enhances processing of positive and negative words in inferior and superior prefrontal cortex. Cortex. 96:31-45, 2017
                                                  3. Hassabis D et al: Imagine all the people: how the brain creates and uses personality models to predict behavior. Cereb Cortex. 24(8):1979-87, 2014
                                                  4. Laurent HK et al: A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry. Soc Cogn Affect Neurosci. 7(2):125-34, 2012
                                                  5. Samson F et al: Enhanced visual functioning in autism: an ALE meta-analysis. Hum Brain Mapp. 33(7):1553-81, 2012
                                                  6. Spreng RN et al: I remember you: a role for memory in social cognition and the functional neuroanatomy of their interaction. Brain Res. 1428:43-50, 2012
                                                  7. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                                                  8. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                                                  9. Andrews-Hanna JR et al: Functional-anatomic fractionation of the brain's default network. Neuron. 65(4):550-62, 2010
                                                  10. Spreng RN et al: Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition. Neuroimage. 53(1):303-17, 2010
                                                  11. Spreng RN et al: Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network. J Cogn Neurosci. 22(6):1112-23, 2010
                                                  12. Buckner RL et al: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 29(6):1860-73, 2009
                                                  13. Spreng RN et al: The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis. J Cogn Neurosci. 21(3):489-510, 2009
                                                  14. Buckner RL et al: The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38, 2008
                                                  15. Buckner RL et al: Self-projection and the brain. Trends Cogn Sci. 11(2):49-57, 2007
                                                  16. Buckner RL et al: Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 25(34):7709-17, 2005
                                                  17. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003