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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Supraglottic squamous cell carcinoma (SG-SCCa)
Synonyms
- SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
Definitions
- SCCa originating on mucosa of any part of supraglottic larynx
- SG subsites: Epiglottis, AE folds, & false cords
- SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)
- SCCa originating on mucosa of any part of supraglottic larynx
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
- Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
- Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
- Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
- Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
- Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
- Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
- Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
- Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
- Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
- Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
- Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
- Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
- Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
- Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
- Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
- Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
- Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
- Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
- Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
- Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
- Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
- Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
- Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
- Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
- Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
- Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
- Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
- Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
- Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
- Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
- Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
- Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
- Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
- Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
- Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
- Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Supraglottic squamous cell carcinoma (SG-SCCa)
Synonyms
- SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
Definitions
- SCCa originating on mucosa of any part of supraglottic larynx
- SG subsites: Epiglottis, AE folds, & false cords
- SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)
- SCCa originating on mucosa of any part of supraglottic larynx
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
- Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
- Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
- Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
- Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
- Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
- Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
- Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
- Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
- Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
- Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
- Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
- Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
- Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
- Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
- Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
- Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
- Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
- Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
- Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
- Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
- Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
- Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
- Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
- Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
- Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
- Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
- Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
- Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
- Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
- Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
- Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
- Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
- Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
- Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
- Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
- Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996
