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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Supraglottic squamous cell carcinoma (SG-SCCa)
Synonyms
SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
Definitions
SCCa originating on mucosa of any part of supraglottic larynx
SG subsites: Epiglottis, AE folds, & false cords
SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Supraglottic squamous cell carcinoma (SG-SCCa)
Synonyms
SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
Definitions
SCCa originating on mucosa of any part of supraglottic larynx
SG subsites: Epiglottis, AE folds, & false cords
SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996
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