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Supraglottic Laryngeal Squamous Cell Carcinoma
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Supraglottic squamous cell carcinoma (SG-SCCa)
            • Synonyms

              • SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
            • Definitions

              • SCCa originating on mucosa of any part of supraglottic larynx
                • SG subsites: Epiglottis, AE folds, & false cords
                • SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Reporting Tips

                                                Selected References

                                                1. Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
                                                2. Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
                                                3. Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
                                                4. Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
                                                5. Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
                                                6. Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
                                                7. Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
                                                8. Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
                                                9. Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
                                                10. Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
                                                11. Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
                                                12. Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
                                                13. Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
                                                14. Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
                                                15. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                16. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                17. Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
                                                18. Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
                                                19. Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
                                                20. Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
                                                21. Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
                                                22. Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
                                                23. Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
                                                24. Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
                                                25. Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
                                                26. Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
                                                27. Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
                                                28. Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
                                                29. Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
                                                30. Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
                                                31. Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
                                                32. Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
                                                33. Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
                                                34. Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
                                                35. Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
                                                36. Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
                                                37. Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
                                                38. Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
                                                39. Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
                                                40. Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Supraglottic squamous cell carcinoma (SG-SCCa)
                                                          • Synonyms

                                                            • SCCa of epiglottis, aryepiglottic (AE) folds, false vocal cords
                                                          • Definitions

                                                            • SCCa originating on mucosa of any part of supraglottic larynx
                                                              • SG subsites: Epiglottis, AE folds, & false cords
                                                              • SG deep spaces: Preepiglottic space (PES) & paraglottic space (PGS)

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Gómez Serrano M et al: Cartilage invasion patterns in laryngeal cancer. Eur Arch Otorhinolaryngol. 273(7):1863-9, 2016
                                                                                              2. Gun R et al: Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery. J Surg Oncol. 112(7):690-6, 2015
                                                                                              3. Jager EA et al: GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation. Radiat Oncol. 10:26, 2015
                                                                                              4. Mor N et al: Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am. 48(4):533-45, 2015
                                                                                              5. Arshad H et al: Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 150(2):237-44, 2014
                                                                                              6. Haque MN et al: Regional metastasis in supraglottic and glottic carcinoma of larynx. Mymensingh Med J. 23(1):121-4, 2014
                                                                                              7. Kayhan FT et al: Transoral robotic supraglottic partial laryngectomy. J Craniofac Surg. 25(4):1422-6, 2014
                                                                                              8. Hartl DM et al: CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270(1):287-91, 2013
                                                                                              9. Gilbert K et al: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT. AJNR Am J Neuroradiol. 31(2):251-6, 2010
                                                                                              10. Al-Khatib T et al: Routine thyroidectomy in total laryngectomy: is it really indicated? J Otolaryngol Head Neck Surg. 38(5):564-7, 2009
                                                                                              11. Ganly I et al: Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 31(11):1489-95, 2009
                                                                                              12. Li X et al: Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. J Laryngol Otol Suppl. (31):11-7, 2009
                                                                                              13. Remacle M et al: Endoscopic partial supraglottic laryngectomies: techniques and results. Otolaryngol Head Neck Surg. 141(3):374-81, 2009
                                                                                              14. Silver CE et al: Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 266(9):1333-52, 2009
                                                                                              15. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                                                              16. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                                                              17. Curtin HD: The "evil gray": cancer and cartilage. Radiology. 249(2):410-2, 2008
                                                                                              18. Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
                                                                                              19. Kim JW et al: Correlation between radiological images and pathological results in supraglottic cancer. J Laryngol Otol. 122(11):1224-9, 2008
                                                                                              20. Ljumanovic R et al: Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol. 18(10):2231-40, 2008
                                                                                              21. Connor S: Laryngeal cancer: how does the radiologist help? Cancer Imaging. 7:93-103, 2007
                                                                                              22. Dagan R et al: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 30(2):186-90, 2007
                                                                                              23. Ljumanovic R et al: Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? AJNR Am J Neuroradiol. 28(8):1540-6, 2007
                                                                                              24. Hoffman HT et al: Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 116(9 Pt 2 Suppl 111):1-13, 2006
                                                                                              25. Daisne JF et al: Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100. Epub 2004 Aug 18. Erratum in: Radiology. 235(3):1086, 2005
                                                                                              26. Mukherji SK et al: Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer. 103(12):2616-22, 2005
                                                                                              27. Chiu RJ et al: Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg. 131(4):485-8, 2004
                                                                                              28. Hamilton S et al: Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 33(5):289-94, 2004
                                                                                              29. Ljumanović R et al: Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology. 232(2):440-8, 2004
                                                                                              30. Redaelli de Zinis LO et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck. 24(10):913-20, 2002
                                                                                              31. Rodrigo JP et al: Clinicopathologic significance of expression of CD44s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx. Am J Clin Pathol. 118(1):67-72, 2002
                                                                                              32. Nagahashi T et al: Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. Auris Nasus Larynx. 28 Suppl:S95-8, 2001
                                                                                              33. Hartig G et al: Supraglottic cancer. Head Neck. 22(4):426-34, 2000
                                                                                              34. Mukherji SK et al: The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck. 22(3):282-7, 2000
                                                                                              35. Orus C et al: Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 257(9):512-6, 2000
                                                                                              36. Thabet MH et al: Pitfalls in the surgical management of cancer of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 123(4):482-7, 2000
                                                                                              37. Hermans R et al: Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 44(4):755-65, 1999
                                                                                              38. Vermund H et al: Survival of patients with squamous cell carcinoma of the supraglottic larynx--thirty-five-year experience with radiotherapy. Acta Oncol. 38(7):961-8, 1999
                                                                                              39. Lo SM et al: Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 27(5):247-51, 1998
                                                                                              40. Scholnick SB et al: Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J Natl Cancer Inst. 88(22):1676-82, 1996