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KEY FACTS
Imaging
Top Differential Diagnoses
Pathology
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Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Supratentorial ependymoma (STE)
Synonyms
- Hemispheric STE (a.k.a. brain surface ependymoma)
- Supratentorial ectopic cortical ependymoma
- Cortical ependymoma
Definitions
- Ependymoma in supratentorial location
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Lillard JC et al: Pediatric supratentorial ependymoma: surgical, clinical, and molecular analysis. Neurosurgery. 85(1):41-9. 2018
- Nowak J et al: MRI phenotype of RELA-fused pediatric supratentorial ependymoma. Clin Neuroradiol. ePub, 2018
- Onishi S et al: RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging. Brain Tumor Pathol. 35(1):41-5, 2018
- Sun S et al: Clinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. J Neurosurg. 128(5):1396-1402, 2018
- Witt DA et al: Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: implications for PD-1-targeted therapy. Pediatr Blood Cancer. 65(5):e26960, 2018
- Gessi M et al: Role of immunohistochemistry in the Identification of supratentorial C11ORF95-RELA fused ependymoma in routine neuropathology. Am J Surg Pathol. 43(1):56-63, 2017
- de Andrade FG et al: Immunohistochemical expression of cyclin D1 is higher in supratentorial ependymomas and predicts relapses in gross total resection cases. Neuropathology. 35(4):312-3, 2015
- Mohaghegh MR et al: Supratentorial cortical ependymoma: an unusual presentation of a rare tumor. Adv Biomed Res. 4:72, 2015
- Pajtler KW et al: Molecular classification of ependymal tumors across All CNS compartments, histopathological grades, and age groups. Cancer Cell. 27(5):728-43, 2015
- Khilji MF et al: Supratentorial extraventricular anaplastic ependymoma in a child. BMJ Case Rep. 2014, 2014
- Purdy E et al: Ependymoma in children under the age of 3 years: a report from the Canadian Pediatric Brain Tumour Consortium. J Neurooncol. 117(2):359-64, 2014
- Alexiou GA et al: Supratentorial ependymomas in children: analysis of nine cases. J Pediatr Neurosci. 8(1):15-8, 2013
- Cage TA et al: A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 11(6):673-81, 2013
- Li JY et al: Giant cell ependymoma-report of three cases and review of the literature. Int J Clin Exp Pathol. 5(5):458-62, 2012
- Reis F et al: Supratentorial tanycytic ependymoma: an uncommon fibrillary ependymoma variant. Arq Neuropsiquiatr. 69(4):723, 2011
- Niazi TN et al: WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment options. J Neurooncol. 91(3):323-8, 2009
- Yi W et al: Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age. Clin Neuropathol. 28(1):21-7, 2009
- Lehman NL: Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation? J Neuropathol Exp Neurol. 67(3):177-88, 2008
- Lehman NL: Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors. J Neuropathol Exp Neurol. 67(9):900-10, 2008
- Miyazawa T et al: Supratentorial ectopic cortical ependymoma occurring with intratumoral hemorrhage. Brain Tumor Pathol. 24(1):35-40, 2007
- Rousseau E et al: Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. Mol Cancer. 6:47, 2007
- Vinchon M et al: Supratentorial ependymoma in children. Pediatr Neurosurg. 34(2):77-87, 2001
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Supratentorial ependymoma (STE)
Synonyms
- Hemispheric STE (a.k.a. brain surface ependymoma)
- Supratentorial ectopic cortical ependymoma
- Cortical ependymoma
Definitions
- Ependymoma in supratentorial location
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Lillard JC et al: Pediatric supratentorial ependymoma: surgical, clinical, and molecular analysis. Neurosurgery. 85(1):41-9. 2018
- Nowak J et al: MRI phenotype of RELA-fused pediatric supratentorial ependymoma. Clin Neuroradiol. ePub, 2018
- Onishi S et al: RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging. Brain Tumor Pathol. 35(1):41-5, 2018
- Sun S et al: Clinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. J Neurosurg. 128(5):1396-1402, 2018
- Witt DA et al: Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: implications for PD-1-targeted therapy. Pediatr Blood Cancer. 65(5):e26960, 2018
- Gessi M et al: Role of immunohistochemistry in the Identification of supratentorial C11ORF95-RELA fused ependymoma in routine neuropathology. Am J Surg Pathol. 43(1):56-63, 2017
- de Andrade FG et al: Immunohistochemical expression of cyclin D1 is higher in supratentorial ependymomas and predicts relapses in gross total resection cases. Neuropathology. 35(4):312-3, 2015
- Mohaghegh MR et al: Supratentorial cortical ependymoma: an unusual presentation of a rare tumor. Adv Biomed Res. 4:72, 2015
- Pajtler KW et al: Molecular classification of ependymal tumors across All CNS compartments, histopathological grades, and age groups. Cancer Cell. 27(5):728-43, 2015
- Khilji MF et al: Supratentorial extraventricular anaplastic ependymoma in a child. BMJ Case Rep. 2014, 2014
- Purdy E et al: Ependymoma in children under the age of 3 years: a report from the Canadian Pediatric Brain Tumour Consortium. J Neurooncol. 117(2):359-64, 2014
- Alexiou GA et al: Supratentorial ependymomas in children: analysis of nine cases. J Pediatr Neurosci. 8(1):15-8, 2013
- Cage TA et al: A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 11(6):673-81, 2013
- Li JY et al: Giant cell ependymoma-report of three cases and review of the literature. Int J Clin Exp Pathol. 5(5):458-62, 2012
- Reis F et al: Supratentorial tanycytic ependymoma: an uncommon fibrillary ependymoma variant. Arq Neuropsiquiatr. 69(4):723, 2011
- Niazi TN et al: WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment options. J Neurooncol. 91(3):323-8, 2009
- Yi W et al: Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age. Clin Neuropathol. 28(1):21-7, 2009
- Lehman NL: Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation? J Neuropathol Exp Neurol. 67(3):177-88, 2008
- Lehman NL: Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors. J Neuropathol Exp Neurol. 67(9):900-10, 2008
- Miyazawa T et al: Supratentorial ectopic cortical ependymoma occurring with intratumoral hemorrhage. Brain Tumor Pathol. 24(1):35-40, 2007
- Rousseau E et al: Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. Mol Cancer. 6:47, 2007
- Vinchon M et al: Supratentorial ependymoma in children. Pediatr Neurosurg. 34(2):77-87, 2001
