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Swyer-James-MacLeod Syndrome
Laura E. Heyneman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Swyer-James syndrome
                • MacLeod syndrome
                • Controversy regarding eponyms to be ascribed to syndrome
                  • MacLeod presented report of 9 patients with "abnormal transradiancy of 1 lung," which was "small or normal size" at the British Thoracic Society meeting in London in February of 1952
                  • Swyer and James published case of "unilateral pulmonary emphysema" in 1953
                  • MacLeod published his work in 1954
              • Definitions

                • Constrictive bronchiolitis secondary to childhood infectious bronchiolitis (typically from adenovirus infection)
                • Constrictive bronchiolitis: Irreversible obstructive small airways disease characterized by submucosal and peribronchiolar fibrosis with resultant destruction and obliterative scarring of small airways

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Milanese G et al: Lung volume reduction of pulmonary emphysema: the radiologist task. Curr Opin Pulm Med. 22(2):179-86, 2016
                                        2. Yu J: Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean J Pediatr. 58(12):459-65, 2015
                                        3. Mosquera RA et al: Dysanaptic growth of lung and airway in children with post-infectious bronchiolitis obliterans. Clin Respir J. 8(1):63-71, 2014
                                        4. Xie BQ et al: Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. PLoS One. 9(5):e98381, 2014
                                        5. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012
                                        6. Champs NS et al: Post-infectious bronchiolitis obliterans in children. J Pediatr (Rio J). 87(3):187-98, 2011
                                        7. Dillman JR et al: Expanding upon the unilateral hyperlucent hemithorax in children. Radiographics. 31(3):723-41, 2011
                                        8. Müller NL: Unilateral hyperlucent lung: MacLeod versus Swyer-James. Clin Radiol. 59(11):1048, 2004
                                        9. Lucaya J et al: Spectrum of manifestations of Swyer-James-MacLeod syndrome. J Comput Assist Tomogr. 22(4):592-7, 1998
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Swyer-James syndrome
                                                      • MacLeod syndrome
                                                      • Controversy regarding eponyms to be ascribed to syndrome
                                                        • MacLeod presented report of 9 patients with "abnormal transradiancy of 1 lung," which was "small or normal size" at the British Thoracic Society meeting in London in February of 1952
                                                        • Swyer and James published case of "unilateral pulmonary emphysema" in 1953
                                                        • MacLeod published his work in 1954
                                                    • Definitions

                                                      • Constrictive bronchiolitis secondary to childhood infectious bronchiolitis (typically from adenovirus infection)
                                                      • Constrictive bronchiolitis: Irreversible obstructive small airways disease characterized by submucosal and peribronchiolar fibrosis with resultant destruction and obliterative scarring of small airways

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Milanese G et al: Lung volume reduction of pulmonary emphysema: the radiologist task. Curr Opin Pulm Med. 22(2):179-86, 2016
                                                                              2. Yu J: Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean J Pediatr. 58(12):459-65, 2015
                                                                              3. Mosquera RA et al: Dysanaptic growth of lung and airway in children with post-infectious bronchiolitis obliterans. Clin Respir J. 8(1):63-71, 2014
                                                                              4. Xie BQ et al: Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. PLoS One. 9(5):e98381, 2014
                                                                              5. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012
                                                                              6. Champs NS et al: Post-infectious bronchiolitis obliterans in children. J Pediatr (Rio J). 87(3):187-98, 2011
                                                                              7. Dillman JR et al: Expanding upon the unilateral hyperlucent hemithorax in children. Radiographics. 31(3):723-41, 2011
                                                                              8. Müller NL: Unilateral hyperlucent lung: MacLeod versus Swyer-James. Clin Radiol. 59(11):1048, 2004
                                                                              9. Lucaya J et al: Spectrum of manifestations of Swyer-James-MacLeod syndrome. J Comput Assist Tomogr. 22(4):592-7, 1998