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Swyer-James Syndrome
Hank Baskin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Swyer-James syndrome (SJS)
            • Synonyms

              • Swyer-James-MacLeod syndrome, Brett syndrome, postinfectious bronchiolitis obliterans (BO)
            • Definitions

              • Acquired unilateral pulmonary hypoplasia thought to result from childhood viral infection
              • Results in small, hyperexpanded lung with relatively ↓ vascularity & (rarely) bronchiectasis
              • Imaging findings may appear as early as 9 months after initial infectious insult

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Behrendt A et al: Swyer-James-MacLeod syndrome. StatPearls, 2021
                                2. Cherian SV et al: Lung hyperlucency: a clinical-radiologic algorithmic approach to diagnosis. Chest. 157(1):119-41, 2020
                                3. Gomes de Farias LP et al: Swyer-James-MacLeod syndrome: the hyperlucent lung. Radiol Cardiothorac Imaging. 2(3):e190246, 2020
                                4. Machado D et al: Swyer-James-Macleod syndrome as a rare cause of unilateral hyperlucent lung: three case reports. Medicine (Baltimore). 98(6):e14269, 2019
                                5. Hamada S et al: Swyer-James-Macleod syndrome: the differential diagnosis of unilateral hyperlucency. Intern Med. 57(17):2591-2, 2018
                                6. Dirweesh A et al: A unilateral hyperlucent lung - Swyer-James syndrome: a case report and literature review. Respir Med Case Rep. 20:104-6, 2017
                                7. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Swyer-James syndrome (SJS)
                                          • Synonyms

                                            • Swyer-James-MacLeod syndrome, Brett syndrome, postinfectious bronchiolitis obliterans (BO)
                                          • Definitions

                                            • Acquired unilateral pulmonary hypoplasia thought to result from childhood viral infection
                                            • Results in small, hyperexpanded lung with relatively ↓ vascularity & (rarely) bronchiectasis
                                            • Imaging findings may appear as early as 9 months after initial infectious insult

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Behrendt A et al: Swyer-James-MacLeod syndrome. StatPearls, 2021
                                                              2. Cherian SV et al: Lung hyperlucency: a clinical-radiologic algorithmic approach to diagnosis. Chest. 157(1):119-41, 2020
                                                              3. Gomes de Farias LP et al: Swyer-James-MacLeod syndrome: the hyperlucent lung. Radiol Cardiothorac Imaging. 2(3):e190246, 2020
                                                              4. Machado D et al: Swyer-James-Macleod syndrome as a rare cause of unilateral hyperlucent lung: three case reports. Medicine (Baltimore). 98(6):e14269, 2019
                                                              5. Hamada S et al: Swyer-James-Macleod syndrome: the differential diagnosis of unilateral hyperlucency. Intern Med. 57(17):2591-2, 2018
                                                              6. Dirweesh A et al: A unilateral hyperlucent lung - Swyer-James syndrome: a case report and literature review. Respir Med Case Rep. 20:104-6, 2017
                                                              7. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012