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Swyer-James
Hank Baskin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Swyer-James syndrome (SJS)
            • Synonyms

              • Swyer-James-MacLeod syndrome, Brett syndrome, postinfectious bronchiolitis obliterans (BO)
            • Definitions

              • Acquired unilateral pulmonary hypoplasia thought to result from childhood viral infection
              • Results in small, hyperexpanded lung with relative decreased vascularity & (rarely) bronchiectasis
              • Imaging findings may appear as early as 9 months after initial infectious insult

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012
                                2. Dillman JR et al: Expanding upon the Unilateral Hyperlucent Hemithorax in Children. Radiographics. 31(3):723-41, 2011
                                3. Sulaiman A et al: Swyer-James-MacLeod syndrome; repeated chest drainages in a patient misdiagnosed with pneumothorax. Interact Cardiovasc Thorac Surg. 8(4):482-4, 2009
                                4. Pipavath SJ et al: Radiologic and pathologic features of bronchiolitis. AJR Am J Roentgenol. 185(2):354-63, 2005
                                5. Fregonese L et al: Clinical, physiologic, and roentgenographic changes after pneumonectomy in a boy with Macleod/Swyer-James syndrome and bronchiectasis. Pediatr Pulmonol. 34(5):412-6, 2002
                                6. Mauad T et al: Histology of childhood bronchiolitis obliterans. Pediatr Pulmonol. 33(6):466-74, 2002
                                7. Zhang L et al: [Bronchiolitis obliterans in children.] J Pediatr (Rio J). 76(3):185-92, 2000
                                8. Schlesinger C et al: Constrictive (obliterative) bronchiolitis: diagnosis, etiology, and a critical review of the literature. Ann Diagn Pathol. 2(5):321-34, 1998
                                9. Moore AD et al: Swyer-James syndrome: CT findings in eight patients. AJR Am J Roentgenol. 158(6):1211-5, 1992
                                10. Marti-Bonmati L et al: CT findings in Swyer-James syndrome. Radiology. 172(2):477-80, 1989
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Swyer-James syndrome (SJS)
                                          • Synonyms

                                            • Swyer-James-MacLeod syndrome, Brett syndrome, postinfectious bronchiolitis obliterans (BO)
                                          • Definitions

                                            • Acquired unilateral pulmonary hypoplasia thought to result from childhood viral infection
                                            • Results in small, hyperexpanded lung with relative decreased vascularity & (rarely) bronchiectasis
                                            • Imaging findings may appear as early as 9 months after initial infectious insult

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Wasilewska E et al: Unilateral hyperlucent lung in children. AJR Am J Roentgenol. 198(5):W400-14, 2012
                                                              2. Dillman JR et al: Expanding upon the Unilateral Hyperlucent Hemithorax in Children. Radiographics. 31(3):723-41, 2011
                                                              3. Sulaiman A et al: Swyer-James-MacLeod syndrome; repeated chest drainages in a patient misdiagnosed with pneumothorax. Interact Cardiovasc Thorac Surg. 8(4):482-4, 2009
                                                              4. Pipavath SJ et al: Radiologic and pathologic features of bronchiolitis. AJR Am J Roentgenol. 185(2):354-63, 2005
                                                              5. Fregonese L et al: Clinical, physiologic, and roentgenographic changes after pneumonectomy in a boy with Macleod/Swyer-James syndrome and bronchiectasis. Pediatr Pulmonol. 34(5):412-6, 2002
                                                              6. Mauad T et al: Histology of childhood bronchiolitis obliterans. Pediatr Pulmonol. 33(6):466-74, 2002
                                                              7. Zhang L et al: [Bronchiolitis obliterans in children.] J Pediatr (Rio J). 76(3):185-92, 2000
                                                              8. Schlesinger C et al: Constrictive (obliterative) bronchiolitis: diagnosis, etiology, and a critical review of the literature. Ann Diagn Pathol. 2(5):321-34, 1998
                                                              9. Moore AD et al: Swyer-James syndrome: CT findings in eight patients. AJR Am J Roentgenol. 158(6):1211-5, 1992
                                                              10. Marti-Bonmati L et al: CT findings in Swyer-James syndrome. Radiology. 172(2):477-80, 1989