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Synovial Sarcoma
Catherine C. Roberts, MD; B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Synovial sarcoma (SS)
            • Synonyms

              • Carcinosarcoma, spindle cell carcinoma of soft tissue
              • Archaic: Synovial cell sarcoma, tendosynovial sarcoma, synovioma, malignant synovioma, synovioblastic sarcoma, synovial endothelioma
            • Definitions

              • Malignant soft tissue tumor of uncertain differentiation with predilection for juxtaarticular regions of young patients

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Bakri A et al: Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR Am J Roentgenol. 199(2):W208-15, 2012
                                                  2. Krieg AH et al: Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol. 22(2):458-67, 2011
                                                  3. Bixby SD et al: Synovial sarcoma in children: imaging features and common benign mimics. AJR Am J Roentgenol. 195(4):1026-32, 2010
                                                  4. Hisaoka M et al: Ossifying synovial sarcoma. Pathol Res Pract. 205(3):195-8, 2009
                                                  5. Kishino T et al: Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall. J Clin Ultrasound. 37(4):233-5, 2009
                                                  6. Lisle JW et al: Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. Clin Orthop Relat Res. 467(6):1605-11, 2009
                                                  7. O'Sullivan PJ et al: Radiological features of synovial cell sarcoma. Br J Radiol. 81(964):346-56, 2008
                                                  8. Weiss SW et al: Malignant soft tissue tumors of uncertain type. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 1161-82, 2008
                                                  9. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins. 424-33, 2006
                                                  10. Murphey MD et al: From the archives of the AFIP: Imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics. 26(5):1543-65, 2006
                                                  11. Fisher C et al: Synovial sarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 200-4, 2002
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Synovial sarcoma (SS)
                                                            • Synonyms

                                                              • Carcinosarcoma, spindle cell carcinoma of soft tissue
                                                              • Archaic: Synovial cell sarcoma, tendosynovial sarcoma, synovioma, malignant synovioma, synovioblastic sarcoma, synovial endothelioma
                                                            • Definitions

                                                              • Malignant soft tissue tumor of uncertain differentiation with predilection for juxtaarticular regions of young patients

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Bakri A et al: Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR Am J Roentgenol. 199(2):W208-15, 2012
                                                                                                  2. Krieg AH et al: Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol. 22(2):458-67, 2011
                                                                                                  3. Bixby SD et al: Synovial sarcoma in children: imaging features and common benign mimics. AJR Am J Roentgenol. 195(4):1026-32, 2010
                                                                                                  4. Hisaoka M et al: Ossifying synovial sarcoma. Pathol Res Pract. 205(3):195-8, 2009
                                                                                                  5. Kishino T et al: Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall. J Clin Ultrasound. 37(4):233-5, 2009
                                                                                                  6. Lisle JW et al: Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. Clin Orthop Relat Res. 467(6):1605-11, 2009
                                                                                                  7. O'Sullivan PJ et al: Radiological features of synovial cell sarcoma. Br J Radiol. 81(964):346-56, 2008
                                                                                                  8. Weiss SW et al: Malignant soft tissue tumors of uncertain type. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 1161-82, 2008
                                                                                                  9. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins. 424-33, 2006
                                                                                                  10. Murphey MD et al: From the archives of the AFIP: Imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics. 26(5):1543-65, 2006
                                                                                                  11. Fisher C et al: Synovial sarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 200-4, 2002