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Syphilitic Myelitis
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Neurosyphilis, syphilitic meningomyelitis
            • Definitions

              • CNS infection by spirochete Treponema pallidum

            IMAGING

            • General Features

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • Staging, Grading, & Classification

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              Selected References

                              1. Dong H et al: Syphilitic meningomyelitis misdiagnosed as spinal cord tumor: Case and review. J Spinal Cord Med. 1-5, 2019
                              2. Yuan JL et al: Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. World J Clin Cases. 7(11):1282-90, 2019
                              3. He D et al: Syphilitic myelitis: magnetic resonance imaging features. Neurol India. 62(1):89-91, 2014
                              4. Molina-Olier O et al: [Spinal cord compression due to intraspinal syphilitic gumma in one patient. Clinical case.] Acta Ortop Mex. 26(3):197-201, 2012
                              5. Chilver-Stainer L et al: Syphilitic myelitis: rare, nonspecific, but treatable. Neurology. 72(7):673-5, 2009
                              6. Tsui EY et al: Syphilitic myelitis with diffuse spinal cord abnormality on MR imaging. Eur Radiol. 12(12):2973-6, 2002
                              7. Finelli DA et al: MR imaging of intrinsic inflammatory myelopathies. Magn Reson Imaging Clin N Am. 8(3):541-60, 2000
                              8. Nabatame H et al: MRI of syphilitic myelitis. Neuroradiology. 34(2):105-6, 1992
                              9. Strom T et al: Syphilitic meningomyelitis. Neurology. 41(2 ( Pt 1)):325-6, 1991
                              10. Janier M: Acute syphilitic myelitis in a young man. Genitourin Med. 64(3):206, 1988
                              11. Lowenstein DH et al: Acute syphilitic transverse myelitis: unusual presentation of meningovascular syphilis. Genitourin Med. 63(5):333-8, 1987
                              12. Tashiro K et al: Syphilitic myelitis with its magnetic resonance imaging (MRI) verification and successful treatment. Jpn J Psychiatry Neurol. 41(2):269-71, 1987
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Synonyms

                                          • Neurosyphilis, syphilitic meningomyelitis
                                        • Definitions

                                          • CNS infection by spirochete Treponema pallidum

                                        IMAGING

                                        • General Features

                                          • Imaging Recommendations

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • Staging, Grading, & Classification

                                                CLINICAL ISSUES

                                                • Presentation

                                                  • Demographics

                                                    • Natural History & Prognosis

                                                      • Treatment

                                                        DIAGNOSTIC CHECKLIST

                                                        • Consider

                                                          Selected References

                                                          1. Dong H et al: Syphilitic meningomyelitis misdiagnosed as spinal cord tumor: Case and review. J Spinal Cord Med. 1-5, 2019
                                                          2. Yuan JL et al: Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. World J Clin Cases. 7(11):1282-90, 2019
                                                          3. He D et al: Syphilitic myelitis: magnetic resonance imaging features. Neurol India. 62(1):89-91, 2014
                                                          4. Molina-Olier O et al: [Spinal cord compression due to intraspinal syphilitic gumma in one patient. Clinical case.] Acta Ortop Mex. 26(3):197-201, 2012
                                                          5. Chilver-Stainer L et al: Syphilitic myelitis: rare, nonspecific, but treatable. Neurology. 72(7):673-5, 2009
                                                          6. Tsui EY et al: Syphilitic myelitis with diffuse spinal cord abnormality on MR imaging. Eur Radiol. 12(12):2973-6, 2002
                                                          7. Finelli DA et al: MR imaging of intrinsic inflammatory myelopathies. Magn Reson Imaging Clin N Am. 8(3):541-60, 2000
                                                          8. Nabatame H et al: MRI of syphilitic myelitis. Neuroradiology. 34(2):105-6, 1992
                                                          9. Strom T et al: Syphilitic meningomyelitis. Neurology. 41(2 ( Pt 1)):325-6, 1991
                                                          10. Janier M: Acute syphilitic myelitis in a young man. Genitourin Med. 64(3):206, 1988
                                                          11. Lowenstein DH et al: Acute syphilitic transverse myelitis: unusual presentation of meningovascular syphilis. Genitourin Med. 63(5):333-8, 1987
                                                          12. Tashiro K et al: Syphilitic myelitis with its magnetic resonance imaging (MRI) verification and successful treatment. Jpn J Psychiatry Neurol. 41(2):269-71, 1987