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Systemic Lupus Erythematosus
Julia Alegría, MD; Laura E. Heyneman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Systemic lupus erythematosus (SLE)
            • Definitions

              • SLE: Autoimmune systemic disease of unknown etiology
                • Production of various autoantibodies
                  • Antidouble stranded DNA (dsDNA) and anti-Smith antibodies specific for SLE

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Forbess L et al: The lung in systemic lupus erythematosus. In Systemic Lupus Erythematosus. 427-38, 2021
                                    2. Lange SM et al: Collagen-Vascular Disease Associated With Interstitial Lung 2021
                                    3. Amarnani R et al: Lupus and the lungs: the assessment and management of pulmonary manifestations of systemic lupus erythematosus. Front Med (Lausanne). 7:610257, 2020
                                    4. Hannah JR et al: Pulmonary complications of systemic lupus erythematosus. Semin Respir Crit Care Med. 40(2):227-34, 2019
                                    5. Serra G et al: Thoracic involvement in connective tissue diseases: radiological patterns and follow-up. JBR-BTR. 98(1):3-19, 2015
                                    6. Mittoo S et al: Pulmonary manifestations of systemic lupus erythematosus. Semin Respir Crit Care Med. 35(2):249-54, 2014
                                    7. Goh YP et al: Imaging of systemic lupus erythematosus. Part I: CNS, cardiovascular, and thoracic manifestations. Clin Radiol. 68(2):181-91, 2013
                                    8. Hoey ET et al: Cardiovascular MRI for assessment of infectious and inflammatory conditions of the heart. AJR Am J Roentgenol. 197(1):103-12, 2011
                                    9. Kanne JP et al: Beyond skin deep: thoracic manifestations of systemic disorders affecting the skin. Radiographics. 31(6):1651-68, 2011
                                    10. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Systemic lupus erythematosus (SLE)
                                              • Definitions

                                                • SLE: Autoimmune systemic disease of unknown etiology
                                                  • Production of various autoantibodies
                                                    • Antidouble stranded DNA (dsDNA) and anti-Smith antibodies specific for SLE

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Forbess L et al: The lung in systemic lupus erythematosus. In Systemic Lupus Erythematosus. 427-38, 2021
                                                                      2. Lange SM et al: Collagen-Vascular Disease Associated With Interstitial Lung 2021
                                                                      3. Amarnani R et al: Lupus and the lungs: the assessment and management of pulmonary manifestations of systemic lupus erythematosus. Front Med (Lausanne). 7:610257, 2020
                                                                      4. Hannah JR et al: Pulmonary complications of systemic lupus erythematosus. Semin Respir Crit Care Med. 40(2):227-34, 2019
                                                                      5. Serra G et al: Thoracic involvement in connective tissue diseases: radiological patterns and follow-up. JBR-BTR. 98(1):3-19, 2015
                                                                      6. Mittoo S et al: Pulmonary manifestations of systemic lupus erythematosus. Semin Respir Crit Care Med. 35(2):249-54, 2014
                                                                      7. Goh YP et al: Imaging of systemic lupus erythematosus. Part I: CNS, cardiovascular, and thoracic manifestations. Clin Radiol. 68(2):181-91, 2013
                                                                      8. Hoey ET et al: Cardiovascular MRI for assessment of infectious and inflammatory conditions of the heart. AJR Am J Roentgenol. 197(1):103-12, 2011
                                                                      9. Kanne JP et al: Beyond skin deep: thoracic manifestations of systemic disorders affecting the skin. Radiographics. 31(6):1651-68, 2011
                                                                      10. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009