link
Bookmarks
Systemic Lupus Erythematosus
Karen L. Salzman, MD; Gary M. Nesbit, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
7
15
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Systemic lupus erythematosus (SLE), "lupus"
              • Neuropsychiatric SLE (NPSLE), CNS SLE
            • Definitions

              • Multisystem autoimmune disorder
                • CNS involved in up to 75% (CNS lupus or NPSLE)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Nardone R et al: Longitudinally extensive transverse myelitis in systemic lupus erythematosus: Case report and review of the literature. Clin Neurol Neurosurg. 129C:57-61, 2015
                                              2. Piga M et al: Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement. Autoimmun Rev. ePub, 2015
                                              3. Saison J et al: Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. Lupus. 24(1):74-81, 2015
                                              4. Jeong HW et al: Brain MRI in neuropsychiatric lupus: associations with the 1999 ACR case definitions. Rheumatol Int. ePub, 2014
                                              5. Kaichi Y et al: Brain MR findings in patients with systemic lupus erythematosus with and without antiphospholipid antibody syndrome. AJNR Am J Neuroradiol. 35(1):100-5, 2014
                                              6. Steup-Beekman GM et al: Neuropsychiatric manifestations in patients with systemic lupus erythematosus: epidemiology and radiology pointing to an immune-mediated cause. Ann Rheum Dis. 72 Suppl 2:ii76-9, 2013
                                              7. Borowoy AM et al: Neuropsychiatric lupus: the prevalence and autoantibody associations depend on the definition: results from the 1000 faces of lupus cohort. Semin Arthritis Rheum. 42(2):179-85, 2012
                                              8. Curiel R et al: PET/CT imaging in systemic lupus erythematosus. Ann N Y Acad Sci. 1228:71-80, 2011
                                              9. Lim KS et al: Periodic lateralized epileptiform discharges in neuropsychiatric lupus: association with cerebritis in magnetic resonance imaging and resolution after intravenous immunoglobulin. Lupus. 19(6):748-52, 2010
                                              10. Baizabal-Carvallo JF et al: Posterior reversible encephalopathy syndrome as a complication of acute lupus activity. Clin Neurol Neurosurg. 111(4):359-63, 2009
                                              11. Appenzeller S et al: Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients. Ann Neurol. 64(6):635-43, 2008
                                              12. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                              13. Janardhan V et al: Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study. Stroke. 35(3):736-41, 2004
                                              14. Jennings JE et al: Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance. Neuroradiology. 46(1):15-21, 2004
                                              15. Susac JO et al: MRI findings in Susac's syndrome. Neurology. 61(12):1783-7, 2003
                                              Related Anatomy
                                              Loading...
                                              Related Differential Diagnoses
                                              Loading...
                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Systemic lupus erythematosus (SLE), "lupus"
                                                          • Neuropsychiatric SLE (NPSLE), CNS SLE
                                                        • Definitions

                                                          • Multisystem autoimmune disorder
                                                            • CNS involved in up to 75% (CNS lupus or NPSLE)

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Nardone R et al: Longitudinally extensive transverse myelitis in systemic lupus erythematosus: Case report and review of the literature. Clin Neurol Neurosurg. 129C:57-61, 2015
                                                                                          2. Piga M et al: Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement. Autoimmun Rev. ePub, 2015
                                                                                          3. Saison J et al: Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. Lupus. 24(1):74-81, 2015
                                                                                          4. Jeong HW et al: Brain MRI in neuropsychiatric lupus: associations with the 1999 ACR case definitions. Rheumatol Int. ePub, 2014
                                                                                          5. Kaichi Y et al: Brain MR findings in patients with systemic lupus erythematosus with and without antiphospholipid antibody syndrome. AJNR Am J Neuroradiol. 35(1):100-5, 2014
                                                                                          6. Steup-Beekman GM et al: Neuropsychiatric manifestations in patients with systemic lupus erythematosus: epidemiology and radiology pointing to an immune-mediated cause. Ann Rheum Dis. 72 Suppl 2:ii76-9, 2013
                                                                                          7. Borowoy AM et al: Neuropsychiatric lupus: the prevalence and autoantibody associations depend on the definition: results from the 1000 faces of lupus cohort. Semin Arthritis Rheum. 42(2):179-85, 2012
                                                                                          8. Curiel R et al: PET/CT imaging in systemic lupus erythematosus. Ann N Y Acad Sci. 1228:71-80, 2011
                                                                                          9. Lim KS et al: Periodic lateralized epileptiform discharges in neuropsychiatric lupus: association with cerebritis in magnetic resonance imaging and resolution after intravenous immunoglobulin. Lupus. 19(6):748-52, 2010
                                                                                          10. Baizabal-Carvallo JF et al: Posterior reversible encephalopathy syndrome as a complication of acute lupus activity. Clin Neurol Neurosurg. 111(4):359-63, 2009
                                                                                          11. Appenzeller S et al: Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients. Ann Neurol. 64(6):635-43, 2008
                                                                                          12. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                                                                          13. Janardhan V et al: Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study. Stroke. 35(3):736-41, 2004
                                                                                          14. Jennings JE et al: Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance. Neuroradiology. 46(1):15-21, 2004
                                                                                          15. Susac JO et al: MRI findings in Susac's syndrome. Neurology. 61(12):1783-7, 2003