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Systemic Lupus Erythematosus
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Systemic lupus erythematosus (SLE)
          • Synonyms

            • Lupus; lupus erythematosus
          • Definitions

            • Autoimmune disease characterized by inflammation in multiple organ systems
            • Drug-induced lupus: Uncommon complication of several commonly used medications
              • Characterized by development of lupus-like symptoms, ANA positivity

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          • Criteria for Classification of SLE (ARCheum)

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Chiara T et al: MRI pattern of arthritis in systemic lupus erythematosus: a comparative study with rheumatoid arthritis and healthy subjects. Skeletal Radiol. 44(2):261-6, 2015
                                    2. Nakamura J et al: Age at time of corticosteroid administration is a risk factor for osteonecrosis in pediatric patients with systemic lupus erythematosus: A prospective magnetic resonance imaging study. Arthritis Rheum. 62(2):609-615, 2010
                                    3. Kitaori T et al: Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus. Mod Rheumatol. 19(4):431-6, 2009
                                    4. O'Neill SG et al: Cardiac magnetic resonance imaging in patients with systemic lupus erythematosus. Ann Rheum Dis. 68(9):1478-81, 2009
                                    5. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                    6. Zakavi SR et al: Significance of abnormal myocardial perfusion scintigraphy in young adult patients with SLE. Ann Nucl Med. 23(8):725-8, 2009
                                    7. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                    8. Martinez JB et al: Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clin Exp Rheumatol. 25(1):47-53, 2007
                                    9. Saketkoo LA et al: Revisiting Jaccoud arthropathy as an ultrasound diagnosed erosive arthropathy in systemic lupus erythematosus. J Clin Rheumatol. 13(6):322-7, 2007
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Systemic lupus erythematosus (SLE)
                                            • Synonyms

                                              • Lupus; lupus erythematosus
                                            • Definitions

                                              • Autoimmune disease characterized by inflammation in multiple organ systems
                                              • Drug-induced lupus: Uncommon complication of several commonly used medications
                                                • Characterized by development of lupus-like symptoms, ANA positivity

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • Radiographic Findings

                                                  • MR Findings

                                                    • Ultrasonographic Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            • Criteria for Classification of SLE (ARCheum)

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Chiara T et al: MRI pattern of arthritis in systemic lupus erythematosus: a comparative study with rheumatoid arthritis and healthy subjects. Skeletal Radiol. 44(2):261-6, 2015
                                                                      2. Nakamura J et al: Age at time of corticosteroid administration is a risk factor for osteonecrosis in pediatric patients with systemic lupus erythematosus: A prospective magnetic resonance imaging study. Arthritis Rheum. 62(2):609-615, 2010
                                                                      3. Kitaori T et al: Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus. Mod Rheumatol. 19(4):431-6, 2009
                                                                      4. O'Neill SG et al: Cardiac magnetic resonance imaging in patients with systemic lupus erythematosus. Ann Rheum Dis. 68(9):1478-81, 2009
                                                                      5. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                                                      6. Zakavi SR et al: Significance of abnormal myocardial perfusion scintigraphy in young adult patients with SLE. Ann Nucl Med. 23(8):725-8, 2009
                                                                      7. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                                                      8. Martinez JB et al: Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clin Exp Rheumatol. 25(1):47-53, 2007
                                                                      9. Saketkoo LA et al: Revisiting Jaccoud arthropathy as an ultrasound diagnosed erosive arthropathy in systemic lupus erythematosus. J Clin Rheumatol. 13(6):322-7, 2007