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Systemic Lupus Erythematosus
Kirkland W. Davis, MD, FACR; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Systemic lupus erythematosus (SLE)
            • Synonyms

              • Lupus, lupus erythematosus
            • Definitions

              • Chronic autoimmune disease characterized by inflammation in multiple organ systems
              • Drug-induced lupus: uncommon complication of several commonly used medications
                • Characterized by development of SLE-like symptoms, ANA positivity

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • DEXA Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              • Criteria for Classification of SLE (ACRheum)

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Kirchgesner T et al: Instability of the extensor digitorum tendons in Jaccoud arthropathy assessed by semi-dynamic MRI of the metacarpophalangeal joints. Diagn Interv Imaging. 102(9):553-9, 2021
                                          2. Mahmoud K et al: Ultrasound to identify SLE patients with musculoskeletal symptoms who respond best to therapy: the USEFUL longitudinal multicentre study. Rheumatology (Oxford). 60(11):5194-204, 2021
                                          3. Zayat AS et al: Defining inflammatory musculoskeletal manifestations in systemic lupus erythematosus. Rheumatology (Oxford). 58(2):304-12, 2019
                                          4. Tani C et al: Imaging of joints in systemic lupus erythematosus. Clin Exp Rheumatol. 36 Suppl 114(5):68-73, 2018
                                          5. Ceccarelli F et al: Joint involvement in systemic lupus erythematosus: from pathogenesis to clinical assessment. Semin Arthritis Rheum. 47(1):53-64, 2017
                                          6. Zayat AS et al: The role of ultrasound in assessing musculoskeletal symptoms of systemic lupus erythematosus: a systematic literature review. Rheumatology (Oxford). 55(3):485-94, 2016
                                          7. Chiara T et al: MRI pattern of arthritis in systemic lupus erythematosus: a comparative study with rheumatoid arthritis and healthy subjects. Skeletal Radiol. 44(2):261-6, 2015
                                          8. Edens C et al: Systemic lupus erythematosus, bone health, and osteoporosis. Curr Opin Endocrinol Diabetes Obes. 22(6):422-31, 2015
                                          9. Lins CF et al: Ultrasound evaluation of joints in systemic lupus erythematosus: a systematic review. Eur Radiol. 25(9):2688-92, 2015
                                          10. Nakamura J et al: Age at time of corticosteroid administration is a risk factor for osteonecrosis in pediatric patients with systemic lupus erythematosus: a prospective magnetic resonance imaging study. Arthritis Rheum. 62(2):609-15, 2010
                                          11. Kitaori T et al: Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus. Mod Rheumatol. 19(4):431-6, 2009
                                          12. O'Neill SG et al: Cardiac magnetic resonance imaging in patients with systemic lupus erythematosus. Ann Rheum Dis. 68(9):1478-81, 2009
                                          13. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                          14. Zakavi SR et al: Significance of abnormal myocardial perfusion scintigraphy in young adult patients with SLE. Ann Nucl Med. 23(8):725-8, 2009
                                          15. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                          16. Martinez JB et al: Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clin Exp Rheumatol. 25(1):47-53, 2007
                                          17. Saketkoo LA et al: Revisiting Jaccoud arthropathy as an ultrasound diagnosed erosive arthropathy in systemic lupus erythematosus. J Clin Rheumatol. 13(6):322-7, 2007
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Systemic lupus erythematosus (SLE)
                                                    • Synonyms

                                                      • Lupus, lupus erythematosus
                                                    • Definitions

                                                      • Chronic autoimmune disease characterized by inflammation in multiple organ systems
                                                      • Drug-induced lupus: uncommon complication of several commonly used medications
                                                        • Characterized by development of SLE-like symptoms, ANA positivity

                                                    IMAGING

                                                    • General Features

                                                      • Imaging Recommendations

                                                        • Radiographic Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • DEXA Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Microscopic Features

                                                                      • Criteria for Classification of SLE (ACRheum)

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Kirchgesner T et al: Instability of the extensor digitorum tendons in Jaccoud arthropathy assessed by semi-dynamic MRI of the metacarpophalangeal joints. Diagn Interv Imaging. 102(9):553-9, 2021
                                                                                  2. Mahmoud K et al: Ultrasound to identify SLE patients with musculoskeletal symptoms who respond best to therapy: the USEFUL longitudinal multicentre study. Rheumatology (Oxford). 60(11):5194-204, 2021
                                                                                  3. Zayat AS et al: Defining inflammatory musculoskeletal manifestations in systemic lupus erythematosus. Rheumatology (Oxford). 58(2):304-12, 2019
                                                                                  4. Tani C et al: Imaging of joints in systemic lupus erythematosus. Clin Exp Rheumatol. 36 Suppl 114(5):68-73, 2018
                                                                                  5. Ceccarelli F et al: Joint involvement in systemic lupus erythematosus: from pathogenesis to clinical assessment. Semin Arthritis Rheum. 47(1):53-64, 2017
                                                                                  6. Zayat AS et al: The role of ultrasound in assessing musculoskeletal symptoms of systemic lupus erythematosus: a systematic literature review. Rheumatology (Oxford). 55(3):485-94, 2016
                                                                                  7. Chiara T et al: MRI pattern of arthritis in systemic lupus erythematosus: a comparative study with rheumatoid arthritis and healthy subjects. Skeletal Radiol. 44(2):261-6, 2015
                                                                                  8. Edens C et al: Systemic lupus erythematosus, bone health, and osteoporosis. Curr Opin Endocrinol Diabetes Obes. 22(6):422-31, 2015
                                                                                  9. Lins CF et al: Ultrasound evaluation of joints in systemic lupus erythematosus: a systematic review. Eur Radiol. 25(9):2688-92, 2015
                                                                                  10. Nakamura J et al: Age at time of corticosteroid administration is a risk factor for osteonecrosis in pediatric patients with systemic lupus erythematosus: a prospective magnetic resonance imaging study. Arthritis Rheum. 62(2):609-15, 2010
                                                                                  11. Kitaori T et al: Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus. Mod Rheumatol. 19(4):431-6, 2009
                                                                                  12. O'Neill SG et al: Cardiac magnetic resonance imaging in patients with systemic lupus erythematosus. Ann Rheum Dis. 68(9):1478-81, 2009
                                                                                  13. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                                                                  14. Zakavi SR et al: Significance of abnormal myocardial perfusion scintigraphy in young adult patients with SLE. Ann Nucl Med. 23(8):725-8, 2009
                                                                                  15. Petri M et al: Brain magnetic resonance imaging in newly diagnosed systemic lupus erythematosus. J Rheumatol. 35(12):2348-54, 2008
                                                                                  16. Martinez JB et al: Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clin Exp Rheumatol. 25(1):47-53, 2007
                                                                                  17. Saketkoo LA et al: Revisiting Jaccoud arthropathy as an ultrasound diagnosed erosive arthropathy in systemic lupus erythematosus. J Clin Rheumatol. 13(6):322-7, 2007